PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USHBP1	1	DYDC1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MTUS2	4	TRIM42	0	two hybrid	Rolland T (2014)	1
CALCOCO2	0	CCDC33	3	two hybrid	Rual JF (2005)	1
EPAS1	6	SSBP3	7	affinity chromatography technology	Steunou AL (2012)	1
PDE4DIP	10	TFIP11	5	two hybrid	Rolland T (2014)	1
ARNT2	5	PDE4DIP	10	two hybrid	Corominas R (2014)	1
CALCOCO2	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
DGCR6	0	TRAF2	1	two hybrid	Corominas R (2014)	1
CEP63	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
PLSCR1	0	APP	1	pull down	Olah J (2011)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
BCL6	6	ARNT2	5	affinity chromatography technology	Miles RR (2005)	1
USP7	14	BCL6	6	affinity chromatography technology	Hein MY (2015)	1
ARNT2	5	APP	1	pull down	Olah J (2011)	1
MTUS2	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
NDE1	2	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Corominas R (2014), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF4	1	NPAS2	0	two hybrid	Rozan LM (2006)	1
TRAF1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
ARNT2	5	TACC3	1	two hybrid	Corominas R (2014)	1
ARNT2	5	MAGEA4	0	two hybrid	Corominas R (2014)	1
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
TRIM27	2	TRIM42	0	two hybrid	Rolland T (2014)	1
SIM2	2	ARNT2	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Ooe N (2004), Huttlin EL (2017), Sullivan AE (2016), Sullivan AE (2016)	4
ARNT2	5	SH3GL2	1	two hybrid	Wang J (2011)	1
CCDC33	3	USHBP1	1	two hybrid	Rual JF (2005)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
DGCR6	0	MEIS2	7	two hybrid	Corominas R (2014)	1
ARNT2	5	SPAG5	1	two hybrid	Corominas R (2014)	1
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
SSX2IP	0	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	TAX1BP3	1	two hybrid	Wang J (2011)	1
CCDC33	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
ARNT2	5	CEP63	2	two hybrid	Corominas R (2014)	1
GOLGA2	2	TRIM42	0	two hybrid	Rolland T (2014)	1
TRIM37	7	TRAF1	0	pull down	Zapata JM (2001)	1
ARNT2	5	TADA2A	1	two hybrid	Corominas R (2014)	1
CDR2	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
DGCR6	0	TRAF1	0	two hybrid	Corominas R (2014)	1
ARNT2	5	SORBS3	5	two hybrid	Corominas R (2014)	1
TFIP11	5	SSX2IP	0	two hybrid	Rolland T (2014)	1
KIFC3	3	CCDC33	3	two hybrid	Rolland T (2014)	1
AHR	3	ARNT2	5	pull down	Dougherty EJ (2008)	1
ARNT2	5	RIMBP3	0	two hybrid	Corominas R (2014)	1
TRAF2	1	TRIM42	0	two hybrid	Rolland T (2014)	1
VPS52	0	CCDC33	3	two hybrid	Rolland T (2014)	1
ARNT2	5	TRIM37	7	two hybrid	Corominas R (2014)	1
TRIM37	7	TRAF4	1	pull down	Zapata JM (2001)	1
SH3GL2	1	APP	1	pull down	Olah J (2011)	1
NDE1	2	TSPOAP1	9	two hybrid	Corominas R (2014)	1
ARNT2	5	SYCE1	0	two hybrid	Corominas R (2014)	1
PDE4DIP	10	MTUS2	4	two hybrid	Rolland T (2014)	1
CEP63	2	SSX2IP	0	bioid	Gupta GD (2015)	1
ARNT2	5	CEP57L1	3	two hybrid	Corominas R (2014)	1
ARNT2	5	MIPOL1	1	two hybrid	Corominas R (2014)	1
MEOX2	2	MAGED1	0	two hybrid	Rolland T (2014)	1
NDE1	2	ARNT2	5	two hybrid	Corominas R (2014)	1
NPAS3	5	ARNT2	5	two hybrid	Corominas R (2014)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
ARNT2	5	SSX2IP	0	two hybrid	Corominas R (2014)	1
USP7	14	TRAF4	1	pull down, affinity chromatography technology, affinity chromatography technology	Zapata JM (2001), Yi P (2013), Yi P (2013)	3
MAGEA4	0	APP	1	pull down	Olah J (2011)	1
TRAF4	1	CALCOCO2	0	two hybrid	Rozan LM (2006)	1
DGCR6	0	ARNT2	5	two hybrid	Corominas R (2014)	1
TRAF1	0	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	RBCK1	0	two hybrid	Corominas R (2014)	1
ARNT2	5	TRIM27	2	two hybrid	Corominas R (2014)	1
NDE1	2	LZTS2	4	two hybrid	Corominas R (2014)	1
GOLGA2	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
SPAG5	1	CCDC33	3	two hybrid	Rolland T (2014)	1
ARNT2	5	TRIM23	3	two hybrid	Corominas R (2014)	1
SSX2IP	0	RINT1	1	bioid	Gupta GD (2015)	1
PLSCR1	0	CCDC33	3	two hybrid	Rual JF (2005)	1
MEOX2	2	TRIM42	0	two hybrid	Rolland T (2014)	1
DGCR6	0	GOLGA2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	TRIM27	2	two hybrid	Corominas R (2014)	1
DGCR6	0	REL	5	two hybrid	Corominas R (2014)	1
CCDC33	3	TRIM37	7	two hybrid	Xin X (2009)	1
CDR2	1	KIFC3	3	two hybrid	Rolland T (2014)	1
KIFC3	3	SYCE1	0	two hybrid	Rolland T (2014)	1
TRAF2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
MAGED1	0	CCDC33	3	two hybrid	Rolland T (2014)	1
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
CCDC33	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
ARNT2	5	ZNF341	1	two hybrid	Corominas R (2014)	1
NDE1	2	REL	5	two hybrid	Corominas R (2014)	1
ARNT2	5	MEOX2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	MEOX2	2	two hybrid	Corominas R (2014)	1
BCL6	6	KIFC3	3	two hybrid	Rolland T (2014)	1
DGCR6	0	IKZF3	1	two hybrid	Corominas R (2014)	1
ARNT2	5	IKZF3	1	two hybrid	Corominas R (2014)	1
SIM1	0	ARNT2	5	fluorescent resonance energy transfe	Sullivan AE (2016)	1
ARNT2	5	FNTB	0	affinity chromatography technology	Huttlin EL (2017)	1
DGCR6	0	LZTS2	4	two hybrid	Corominas R (2014)	1
KIFC3	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
GOLGA2	2	DTX2	3	two hybrid	Rolland T (2014)	1
ARNT2	5	GOLGA2	2	two hybrid	Corominas R (2014)	1
ARNT2	5	LZTS2	4	two hybrid	Corominas R (2014)	1
SSX2IP	0	TRIP6	2	bioid	Gupta GD (2015)	1
ARNT2	5	DYDC1	0	two hybrid	Corominas R (2014)	1
TRAF2	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
NDE1	2	GOLGA2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	ADAMTSL4	6	two hybrid	Corominas R (2014)	1
EPAS1	6	ARNT2	5	two hybrid, affinity chromatography technology	Ravasi T (2010), Steunou AL (2012)	2
TRIM23	3	CDR2	1	two hybrid	Rolland T (2014)	1
BCL6	6	TRAF1	0	two hybrid	Rolland T (2014)	1
DGCR6	0	RIMBP3	0	two hybrid	Corominas R (2014)	1
TRIM23	3	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	REL	5	two hybrid	Corominas R (2014)	1
NDE1	2	TFIP11	5	two hybrid	Corominas R (2014)	1
KIFC3	3	TRIM27	2	two hybrid	Rolland T (2014)	1
NDE1	2	USHBP1	1	two hybrid	Corominas R (2014)	1
ARNT2	5	TRIP6	2	two hybrid	Corominas R (2014)	1
ARNT2	5	CTBP1	2	two hybrid	Corominas R (2014)	1
ARNT2	5	FNTA	0	affinity chromatography technology	Huttlin EL (2017)	1
LZTS2	4	SSX2IP	0	affinity chromatography technology	Huttlin EL (2017)	1
ADAMTSL4	6	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	NPAS2	0	two hybrid	Corominas R (2014)	1
SIM2	2	MAGED1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Sullivan AE (2016), Sullivan AE (2016), Sullivan AE (2016), Sullivan AE (2016)	4
TFIP11	5	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down	Ye M (2015), Ye M (2015), Ye M (2015)	3
TRAF2	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2013), Zhang X (2013), Zhang X (2013), Ren HY (2015)	4
ARNT2	5	RFX6	3	two hybrid	Corominas R (2014)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
RIMBP3	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ARNT2	5	TRAF4	1	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
KIFC3	3	APP	1	pull down	Olah J (2011)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
TRIP6	2	ADAMTSL4	6	two hybrid	Rolland T (2014)	1
ARNT2	5	RINT1	1	two hybrid	Corominas R (2014)	1
LZTS2	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
USP7	14	TRAF1	0	pull down	Zapata JM (2001)	1
TRIM23	3	KIFC3	3	two hybrid	Rolland T (2014)	1
ARNT2	5	CALCOCO2	0	two hybrid	Corominas R (2014)	1
ARNT2	5	DTX2	3	two hybrid	Corominas R (2014)	1
CEP63	2	USHBP1	1	two hybrid	Rual JF (2005)	1
RINT1	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
ARNT2	5	USHBP1	1	two hybrid	Corominas R (2014)	1
KIFC3	3	TRAF2	1	two hybrid	Rolland T (2014)	1
NPAS1	4	ARNT2	5	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
ARNT2	5	TRAF2	1	two hybrid	Corominas R (2014)	1
DGCR6	0	CTBP1	2	two hybrid	Corominas R (2014)	1
BCL6	6	CTBP1	2	pull down, affinity chromatography technology, imaging technique	Mendez LM (2008), Mendez LM (2008), Mendez LM (2008)	3
CEP63	2	TRIM37	7	bioid	Gupta GD (2015)	1
PLSCR1	0	DTX2	3	two hybrid	Rual JF (2005)	1
TRIP6	2	DTX2	3	two hybrid	Rolland T (2014)	1
USP7	14	ARNT2	5	two hybrid	Lim J (2006)	1
SSBP3	7	APP	1	pull down	Olah J (2011)	1
ARNT2	5	CCDC33	3	two hybrid	Corominas R (2014)	1
MAGED1	0	NPAS4	0	fluorescent resonance energy transfe, affinity chromatography technology	Sullivan AE (2016), Sullivan AE (2016)	2
DYDC1	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
EPAS1	6	HIF1A	1	affinity chromatography technology	Steunou AL (2012)	1
RINT1	1	SPAG5	1	affinity chromatography technology	Huttlin EL (2017)	1
MEIS2	7	APP	1	pull down	Olah J (2011)	1
DGCR6	0	TFIP11	5	two hybrid	Corominas R (2014)	1
PLSCR1	0	TRIM42	0	two hybrid	Rolland T (2014)	1
TSPOAP1	9	REL	5	two hybrid	Corominas R (2014)	1
ARNT2	5	MEIS2	7	two hybrid	Corominas R (2014)	1
ARNT2	5	CLPP	0	affinity chromatography technology	Huttlin EL (2017)	1
DTX2	3	RFX6	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ARNT2	5	TRIM42	0	two hybrid	Corominas R (2014)	1
ARNT2	5	PLSCR1	0	two hybrid	Corominas R (2014)	1
CEP63	2	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
IKZF3	1	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	ADAMTSL4	6	two hybrid	Corominas R (2014)	1
ARNT2	5	TFIP11	5	two hybrid	Corominas R (2014)	1
DGCR6	0	RFX6	3	two hybrid	Corominas R (2014)	1
DGCR6	0	CCDC33	3	two hybrid	Corominas R (2014)	1
TRIM27	2	SORBS3	5	two hybrid	Rolland T (2014)	1
ARNT2	5	MTUS2	4	two hybrid	Corominas R (2014)	1
MEOX2	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
ARNT2	5	TRAF1	0	two hybrid	Corominas R (2014)	1
ARNT2	5	HIF1A	1	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
PLSCR1	0	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
FNTB	0	FNTA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SORBS3	5	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
NPAS4	0	ARNT2	5	two hybrid	Ooe N (2004)	1
TRIM37	7	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
TFIP11	5	CEP57L1	3	two hybrid	Rolland T (2014)	1
ARNT2	5	SSBP3	7	two hybrid	Corominas R (2014)	1
CCDC33	3	TRIM42	0	two hybrid	Rolland T (2014)	1
ARNT2	5	NCOA3	3	two hybrid	Corominas R (2014)	1
LZTS2	4	TRIM42	0	two hybrid	Rolland T (2014)	1
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
MAGED1	0	SIM1	0	fluorescent resonance energy transfe, affinity chromatography technology	Sullivan AE (2016), Sullivan AE (2016)	2
KIFC3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
TRIP6	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
DGCR6	0	MIPOL1	1	two hybrid	Corominas R (2014)	1
MAGED1	0	ARNT2	5	affinity chromatography technology, fluorescent resonance energy transfe	Sullivan AE (2016), Sullivan AE (2016)	2
TRIM23	3	SORBS3	5	two hybrid	Rolland T (2014)	1
ARNT2	5	TSPOAP1	9	two hybrid	Corominas R (2014)	1
RBCK1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
TRAF4	1	PDE4DIP	10	two hybrid	Rozan LM (2006)	1
ARNT2	5	KIFC3	3	two hybrid	Corominas R (2014)	1
ARNT2	5	VPS52	0	two hybrid	Corominas R (2014)	1
DGCR6	0	APP	1	pull down	Olah J (2011)	1
ARNT2	5	CDR2	1	two hybrid	Corominas R (2014)	1
NPAS2	0	NCOA3	3	pull down	Curtis AM (2004)	1