PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN1	0	UNK	3	biochemical	Havugimana PC (2012)	1
USP46	5	PJA2	4	affinity chromatography technology	Sowa ME (2009)	1
UBXN7	3	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
PJA2	4	PRKAR1A	4	pull down, affinity chromatography technology, enzymatic study	Lignitto L (2011), Lignitto L (2011), Lignitto L (2011)	3
ELAVL1	0	CDK9	3	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	KSR1	0	affinity chromatography technology	Kirli K (2015)	1
CCNT1	3	CDK9	3	pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, genetic interference, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, biochemical, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cabart P (2004), Young TM (2003), Michels AA (2003), Michels AA (2003), Michels AA (2003), Hoque M (2003), Kiernan RE (2001), De Falco G (2000), Fu TJ (1999), Fu TJ (1999), Peng J (1998), Peng J (1998), Peng J (1998), Garber ME (2000), Garber ME (2000), Garber ME (2000), He N (2006), Jeronimo C (2007), Bres V (2009), Gargano B (2007), Yokoyama A (2010), Fryer CJ (2004), Yik JH (2003), Mak AB (2010), Mak AB (2010), Liu M (2012), Shan B (2005), Baumli S (2008), Baumli S (2008), Havugimana PC (2012), Herrmann CH (2001), Herrmann CH (2001), Herrmann CH (2001), Napolitano G (2003), Chen R (2004), Chen R (2004), Chen R (2004), Larochelle S (2012), Yik JH (2005), Napolitano G (1999), Garriga J (1998), Napolitano G (2002), Nguyen VT (2001), Takahashi H (2011), Yang Z (2005), Yang Z (2001), Yang Z (2001), Pinhero R (2004), Byers SA (2005), Wei P (1998), Wei P (1998), Wei P (1998), Wei P (1998), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lin PH (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	64
XPO1	8	PJA2	4	affinity chromatography technology	Kirli K (2015)	1
FAF2	4	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
RIPK4	0	MAGED1	0	affinity chromatography technology	Rodriguez J (2016)	1
CFTR	5	XPO1	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
UBE2J1	1	PJA2	4	two hybrid	van Wijk SJ (2009)	1
EGLN3	0	MAGED2	1	affinity chromatography technology	Rodriguez J (2016)	1
UBXN1	0	MAGED1	0	affinity chromatography technology	Raman M (2015)	1
MAGED1	0	PJA2	4	two hybrid	Sasaki A (2002)	1
ELAVL1	0	UBE2J1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAGED2	1	PJA2	4	affinity chromatography technology	Fogeron ML (2013)	1
FAF1	1	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
XPO1	8	USP46	5	affinity chromatography technology	Kirli K (2015)	1
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
EGLN3	0	PJA2	4	affinity chromatography technology	Rodriguez J (2016)	1
UBXN1	0	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
UBE2N	1	PJA2	4	two hybrid	van Wijk SJ (2009)	1
UBE2D3	1	PJA2	4	two hybrid, pull down	van Wijk SJ (2009), Lignitto L (2011)	2
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
CFTR	5	UBXN1	0	affinity chromatography technology	Pankow S (2015)	1
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
FAF2	4	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
PJA2	4	PRKAR2A	0	pull down, affinity chromatography technology, enzymatic study	Lignitto L (2011), Lignitto L (2011), Lignitto L (2011)	3
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
FAF2	4	CUL3	17	affinity chromatography technology	Alexandru G (2008)	1
EGLN3	0	UBXN1	0	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
KIAA0753	1	PJA2	4	bioid	Firat-Karalar EN (2014)	1
EGLN3	0	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
MAGED2	1	MAGED1	0	affinity chromatography technology	Fogeron ML (2013)	1
CUL3	17	PRKAR1A	4	affinity chromatography technology	Bennett EJ (2010)	1
RIPK4	0	KSR1	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CCNT1	3	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	PRKAR1A	4	affinity chromatography technology	Kirli K (2015)	1
PJA2	4	CDK9	3	affinity chromatography technology	Faust TB (2017)	1
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
XPO1	8	MAGED2	1	affinity chromatography technology	Kirli K (2015)	1
UNK	3	PJA2	4	affinity chromatography technology	Murn J (2015)	1
CUL3	17	MAGED2	1	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	PRKAR1A	4	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	PRKAR2A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	CEP192	5	affinity chromatography technology	Rodriguez J (2016)	1
UNK	3	XPO1	8	affinity chromatography technology	Murn J (2015)	1
CUL3	17	FBXL17	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	MAGED1	0	affinity chromatography technology	Bennett EJ (2010)	1
PJA2	4	KSR1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Rinaldi L (2016), Rinaldi L (2016), Rinaldi L (2016), Rinaldi L (2016), Rinaldi L (2016)	5
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
CEP192	5	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
CEP192	5	PJA2	4	affinity chromatography technology	Gomez-Ferreria MA (2012)	1
UBE2J1	1	FAF2	4	affinity chromatography technology	Claessen JH (2010)	1
FBXL17	4	PJA2	4	affinity chromatography technology	Raducu M (2016)	1
CFTR	5	PJA2	4	affinity chromatography technology	Pankow S (2015)	1
AP2M1	5	PJA2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
EGLN3	0	CDK9	3	affinity chromatography technology	Rodriguez J (2016)	1
FAF2	4	MAGED1	0	affinity chromatography technology	Raman M (2015)	1
MFHAS1	3	PJA2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhong J (2017), Zhong J (2017), Zhong J (2017), Zhong J (2017)	4
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
EGLN3	0	PRKAR2A	0	affinity chromatography technology	Rodriguez J (2016)	1
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
IQCN	0	PJA2	4	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	PRKAR1A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
FAF2	4	UBE2D1	0	pull down	Phan VT (2010)	1
ELAVL1	0	PJA2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN1	0	FAF2	4	affinity chromatography technology	Raman M (2015)	1
CFTR	5	FAF2	4	affinity chromatography technology	Pankow S (2015)	1
RIPK4	0	PJA2	4	affinity chromatography technology	Rodriguez J (2016)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
XPO1	8	PRKAR2A	0	affinity chromatography technology	Kirli K (2015)	1
CUL3	17	PJA2	4	affinity chromatography technology	Bennett EJ (2010)	1
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
PJA2	4	PJA2	4	enzymatic study	Yu P (2002)	1
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
UBE2D4	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
KIAA0753	1	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
UBE2D2	0	PJA2	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), van Wijk SJ (2009), Yu P (2002), Faust TB (2017)	5
UBE2L6	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
RIPK4	0	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
PJA2	4	CCNT1	3	affinity chromatography technology	Faust TB (2017)	1
UBE2D1	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
ARHGAP36	1	PJA2	4	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	MAGED1	0	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1