PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
USP21	2	RNF144A	1	two hybrid	Hayes SD (2012)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2V1	0	RNF144A	1	two hybrid	Markson G (2009)	1
RNF144A	1	CKAP4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
E2F2	0	E2F1	0	imaging technique	Chen TC (2014)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
USP32	0	RNF144A	1	two hybrid	Hayes SD (2012)	1
E2F1	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
UBE2V2	0	RNF144A	1	two hybrid	Markson G (2009)	1
UBC	7	USP32	0	pull down, pull down	Zhang X (2017), Kwasna D (2018)	2
RNF144A	1	PRKDC	12	affinity chromatography technology, pull down, enzymatic study	Ho SR (2014), Ho SR (2014), Ho SR (2014)	3
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
E2F3	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
HNRNPL	3	UBE2K	0	affinity chromatography technology	Fei T (2017)	1
RNF144A	1	RNF144A	1	enzymatic study, enzymatic study, affinity chromatography technology	Ho SR (2014), Ho SR (2015), Ho SR (2015)	3
UBE2K	0	RNF144A	1	two hybrid	Markson G (2009)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
HNRNPL	3	UBE2H	3	affinity chromatography technology	Fei T (2017)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE2H	3	RNF144A	1	two hybrid	Markson G (2009)	1
HNRNPL	3	E2F3	0	affinity chromatography technology	Fei T (2017)	1
RNF144A	1	UBC	7	enzymatic study	Michel MA (2017)	1
E2F2	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
HNRNPL	3	RNF144A	1	affinity chromatography technology	Fei T (2017)	1
UBE2L3	1	RNF144A	1	two hybrid, pull down	Markson G (2009), Ho SR (2014)	2
E2F4	0	RNF144A	1	two hybrid	Schlisio S (2002)	1
UBE2L6	0	RNF144A	1	two hybrid, two hybrid	Markson G (2009), Martinez-Noel G (2001)	2
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10