PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GSK3B	1	NUB1	2	affinity chromatography technology, affinity chromatography technology	Richet E (2012), Richet E (2012)	2
SIAH2	0	SNCA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liani E (2004), Rott R (2008), Rott R (2008), Szargel R (2009), Rott R (2011)	5
SNCAIP	2	PSMC4	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marx FP (2007), Marx FP (2007), Marx FP (2007)	3
CSNK2A1	15	SNCA	0	enzymatic study, enzymatic study	Payton JE (2004), Okochi M (2000)	2
C11orf58	0	PTN	0	two hybrid	Vinayagam A (2011)	1
NUB1	2	SNCAIP	2	two hybrid, affinity chromatography technology, two hybrid	Tanji K (2006), Tanji K (2006), Tanji K (2007)	3
SNCAIP	2	PINK1	2	two hybrid	Bandopadhyay R (2005)	1
YWHAH	0	PPP1CA	3	biochemical	Kristensen AR (2012)	1
RNF19A	3	SNCAIP	2	affinity chromatography technology, enzymatic study	Ito T (2003), Ito T (2003)	2
SNCAIP	2	GET4	3	two hybrid	Stelzl U (2005)	1
SNCAIP	2	SNCA	0	two hybrid, fluorescent resonance energy transfe, two hybrid, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neystat M (2002), Kawamata H (2001), Engelender S (1999), Engelender S (1999), Engelender S (1999), Xie YY (2010), Xie YY (2010), Smith WW (2005), Smith WW (2005), Bandopadhyay R (2005), Lee G (2004), Ryo A (2006), Ryo A (2006), Norris KL (2015), Nagano Y (2001)	15
SNCAIP	2	PTN	0	two hybrid	Stelzl U (2005)	1
C11orf58	0	RNF19A	3	two hybrid	Vinayagam A (2011)	1
NUDT21	0	SNCAIP	2	two hybrid	Vinayagam A (2011)	1
GSK3B	1	PTN	0	two hybrid	Vinayagam A (2011)	1
PPP1CA	3	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji C (2002), Varjosalo M (2013), St-Denis N (2016)	3
SNCAIP	2	SIAH1	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down	Liani E (2004), Liani E (2004), Liani E (2004), Liani E (2004), Nagano Y (2003), Nagano Y (2003), Nagano Y (2003)	7
SNCAIP	2	HERPUD1	2	affinity chromatography technology, affinity chromatography technology	Miura H (2010), Miura H (2010)	2
NUDT21	0	PTN	0	two hybrid	Vinayagam A (2011)	1
NUDT21	0	RNF19A	3	two hybrid	Vinayagam A (2011)	1
SNCAIP	2	SH2D3C	2	two hybrid	Stelzl U (2005)	1
SNCA	0	HERPUD1	2	affinity chromatography technology, affinity chromatography technology	Miura H (2010), Miura H (2010)	2
PPP1CC	2	GSK3B	1	affinity chromatography technology	St-Denis N (2016)	1
YWHAH	0	SNCAIP	2	affinity chromatography technology	Sato S (2006)	1
PPP1CC	2	SNCAIP	2	affinity chromatography technology, two hybrid, far western blotting, imaging technique, affinity chromatography technology	Huttlin EL (2015), Ferreira-Fernandes E (2015), Ferreira-Fernandes E (2015), Ferreira-Fernandes E (2015), Huttlin EL (2017)	5
PPP1CC	2	SIAH2	0	affinity chromatography technology, affinity chromatography technology	Cid C (2007), Cid C (2007)	2
SIAH1	2	SNCA	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lee JT (2008), Lee JT (2008), Rott R (2008), Rott R (2008), Szargel R (2009), Szargel R (2009), Szargel R (2009), Szargel R (2009), Szargel R (2016)	9
PRKN	1	SNCAIP	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid	Chung KK (2001), Chung KK (2001), Chung KK (2001), Sriram SR (2005), Smith WW (2005), Ramsey CP (2010), Kalia SK (2004), Sato S (2006), Parelkar SS (2012), Bandopadhyay R (2005)	10
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
GSK3B	1	SNCAIP	2	enzymatic study, affinity chromatography technology	Avraham E (2005), Avraham E (2005)	2
PPP1CA	3	SNCAIP	2	two hybrid, two hybrid, imaging technique	Esteves SL (2012), Ferreira-Fernandes E (2015), Ferreira-Fernandes E (2015)	3
PRKN	1	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Sato S (2006), Sato S (2006)	2
PIN1	0	SNCA	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Ryo A (2006), Ryo A (2006), Ryo A (2006)	3
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
PPHLN1	0	SNCAIP	2	two hybrid	Soehn AS (2010)	1
SNCAIP	2	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
KALRN	7	SNCAIP	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Tsai YC (2013), Tsai YC (2013), Tsai YC (2013)	3
SIAH1	2	HERPUD1	2	affinity chromatography technology, affinity chromatography technology	Miura H (2010), Miura H (2010)	2
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
PRKN	1	PSMC4	6	affinity chromatography technology	Sarraf SA (2013)	1
SNCAIP	2	SNCAIP	2	pull down, two hybrid	Xie YY (2010), Bandopadhyay R (2005)	2
PPP1CC	2	PPHLN1	0	affinity chromatography technology	Hein MY (2015)	1
C11orf58	0	SNCAIP	2	two hybrid	Vinayagam A (2011)	1
SIAH2	0	SNCAIP	2	enzymatic study	Avraham E (2005)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
PINK1	2	SNCA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Um JW (2009), Um JW (2009), Szargel R (2016), Szargel R (2016)	4
CSNK2A1	15	SNCAIP	2	enzymatic study, affinity chromatography technology, affinity chromatography technology	Lee G (2004), Lee G (2004), Lee G (2004)	3
SNCAIP	2	PIN1	0	affinity chromatography technology, affinity chromatography technology, unspecified method	Ryo A (2006), Ryo A (2006), Ryo A (2006)	3
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
PIN1	0	CSNK2A1	15	pull down, affinity chromatography technology	Messenger MM (2002), Messenger MM (2002)	2
GSK3B	1	SNCA	0	pull down	Kawakami F (2011)	1