PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
EGFR	5	APPL1	1	unspecified method	Jones RB (2006)	1
SOCS6	0	CDK5RAP2	3	affinity chromatography technology	Huttlin EL (2015)	1
KIT	4	PIK3R2	3	two hybrid	De Sepulveda P (1999)	1
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
SOCS6	0	WDR89	0	two hybrid	Wang J (2011)	1
SOCS6	0	USP1	4	affinity chromatography technology	Huttlin EL (2015)	1
SOCS6	0	MADD	8	affinity chromatography technology	Huttlin EL (2015)	1
IRS4	2	PIK3R3	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
SOCS6	0	DAB1	1	pull down	Simo S (2013)	1
DCUN1D1	0	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
IRS4	2	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CLNK	2	PIK3R1	6	two hybrid	Grossmann A (2015)	1
CLNK	2	CRK	0	two hybrid	Grossmann A (2015)	1
DCUN1D1	0	TUBB4B	6	affinity chromatography technology	Bennett EJ (2010)	1
SOCS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zadjali F (2011), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
INSR	9	SOCS6	0	affinity chromatography technology	Mooney RA (2001)	1
EGFR	5	PIK3R2	3	affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, protein complementation assay	Tong J (2009), Jones RB (2006), Foerster S (2013), Kotlyar M (2015), Gout I (1992), Petschnigg J (2014)	6
SOCS6	0	LNX1	7	two hybrid	Grossmann A (2015)	1
EFEMP1	1	SOCS6	0	two hybrid	Wang J (2011)	1
SOCS6	0	KDM1A	2	two hybrid	Weimann M (2013)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
APPL1	1	PIK3R2	3	two hybrid	Grossmann A (2015)	1
HSP90AA1	7	TUBB4B	6	affinity chromatography technology	Skarra DV (2011)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
EGFR	5	ACACA	5	affinity chromatography technology	Tong J (2014)	1
LNX1	7	FBXO11	14	affinity chromatography technology	Lenihan JA (2017)	1
LNX1	7	UBE2D2	0	pull down, pull down, pull down	Nie J (2002), Nie J (2004), Guo Z (2012)	3
DAB1	1	LNX1	7	two hybrid	Rolland T (2014)	1
PIK3R2	3	ACACA	5	affinity chromatography technology	Brehme M (2009)	1
ARIH2	4	ELOB	1	affinity chromatography technology	Kelsall IR (2013)	1
SOCS6	0	ACACA	5	affinity chromatography technology	Huttlin EL (2015)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
HSP90AA1	7	FAM83H	6	affinity chromatography technology	Gano JJ (2010)	1
EGFR	5	SOCS6	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
UBE2D2	0	RELA	1	enzymatic study	Ryo A (2003)	1
CRK	0	SOCS6	0	two hybrid	Grossmann A (2015)	1
CLNK	2	SOCS6	0	two hybrid	Grossmann A (2015)	1
UBE2D2	0	PLEC	39	affinity chromatography technology	Boldt K (2016)	1
UBE2D2	0	ARIH2	4	two hybrid	Markson G (2009)	1
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
SOCS6	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Krebs DL (2002), Zadjali F (2011)	2
CLNK	2	PIK3R3	0	two hybrid	Grossmann A (2015)	1
CRK	0	PIK3R3	0	affinity chromatography technology, two hybrid	Brehme M (2009), Grossmann A (2015)	2
IRS4	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ARIH2	4	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Kelsall IR (2013), Kelsall IR (2013), Kelsall IR (2013), Kelsall IR (2013), Kelsall IR (2013)	5
EGFR	5	TUBB4B	6	affinity chromatography technology	Foerster S (2013)	1
SOCS6	0	IRS4	2	affinity chromatography technology	Krebs DL (2002)	1
SOCS6	0	PIK3R1	6	affinity chromatography technology	Krebs DL (2002)	1
SOCS6	0	UBE2I	0	two hybrid	Wang J (2011)	1
LNX1	7	ELOC	0	affinity chromatography technology	Lenihan JA (2017)	1
APPL1	1	PIK3R1	6	affinity chromatography technology, two hybrid	Yang L (2003), Grossmann A (2015)	2
KIT	4	CRK	0	two hybrid	Yokouchi M (1997)	1
SOCS6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APPL1	1	SOCS6	0	two hybrid	Grossmann A (2015)	1
SOCS6	0	KIAA0232	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
IRS4	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Sano H (2002), Skarra DV (2011)	2
SOCS6	0	SAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIK3R3	0	PIK3R1	6	affinity chromatography technology	Huttlin EL (2017)	1
FRS3	0	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
IRS4	2	EGFR	5	unspecified method, affinity chromatography technology	Jones RB (2006), Tong J (2014)	2
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
HSP90AA1	7	LNX1	7	affinity chromatography technology	Taipale M (2012)	1
DCUN1D1	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
SOCS6	0	TUBA1A	13	affinity chromatography technology	Krebs DL (2002)	1
FRS3	0	SOCS6	0	two hybrid	Grossmann A (2015)	1
CRK	0	TUBA1A	13	affinity chromatography technology	Brehme M (2009)	1
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
PIK3R2	3	PIK3R3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
SOCS6	0	PIK3R2	3	affinity chromatography technology	Krebs DL (2002)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
EGFR	5	CLNK	2	unspecified method	Jones RB (2006)	1
SOCS6	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Krebs DL (2002), Zadjali F (2011), Huttlin EL (2015), Huttlin EL (2017)	4
CUL5	1	TUBB4B	6	affinity chromatography technology	Bennett EJ (2010)	1
SOCS6	0	PIK3R3	0	affinity chromatography technology, two hybrid	Huttlin EL (2015), Grossmann A (2015)	2
EGFR	5	TUBA1A	13	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
IRS4	2	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TUBA1A	13	TUBB4B	6	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PIK3R2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	3
SOCS6	0	KIT	4	affinity chromatography technology, enzymatic study, x-ray crystallography	Zadjali F (2011), Zadjali F (2011), Zadjali F (2011)	3
CRK	0	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
SOCS6	0	ZMIZ2	1	two hybrid	Wang J (2011)	1
SOCS6	0	PLEC	39	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SAV1	0	IRS4	2	affinity chromatography technology	Couzens AL (2013)	1
DCUN1D1	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
ARIH2	4	ELOC	0	affinity chromatography technology	Kelsall IR (2013)	1
HSP90AA1	7	SOCS6	0	affinity chromatography technology	Taipale M (2012)	1
SOCS6	0	UBE2D2	0	pull down	Zadjali F (2011)	1
SOCS6	0	TUBB4B	6	affinity chromatography technology	Krebs DL (2002)	1
CRK	0	IRS4	2	affinity chromatography technology, pull down	Karas M (2001), Koval AP (1998)	2
SOCS6	0	FAM83H	6	affinity chromatography technology	Huttlin EL (2015)	1
SOCS6	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
SOCS6	0	ARIH2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
SOCS6	0	TUBD1	0	affinity chromatography technology	Krebs DL (2002)	1
PIK3R2	3	CRK	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Brehme M (2009), Brehme M (2009), Grossmann A (2015)	3
DCUN1D1	0	SOCS6	0	affinity chromatography technology	Bennett EJ (2010)	1
RELA	1	SOCS6	0	two hybrid	Wang J (2011)	1