PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUMO2	0	KDM1A	2	pull down	Ouyang J (2009)	1
ZBED1	0	LRRC20	0	two hybrid	Rolland T (2014)	1
ZBED1	0	KLHL40	4	two hybrid	Rolland T (2014)	1
SUMO2	0	GATAD2B	15	pull down	Ouyang J (2009)	1
SUMO2	0	ATRX	7	pull down	Ouyang J (2009)	1
TWF1	2	ZBED1	0	biochemical	Havugimana PC (2012)	1
ZBED1	0	MTA2	1	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
MBD3	4	GATAD2B	15	pull down, pull down, affinity chromatography technology, imaging technique, pull down, two hybrid, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Brackertz M (2002), Feng Q (2002), Feng Q (2002), Feng Q (2002), Gong Z (2006), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	10
ZBED1	0	USP22	1	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	SORBS3	5	two hybrid	Rual JF (2005)	1
UBE2I	0	ZBED1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATP6V1B2	3	ZBED1	0	biochemical	Havugimana PC (2012)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
TWF1	2	UBE2A	0	biochemical	Havugimana PC (2012)	1
SSX2	0	ZBED1	0	two hybrid	Rolland T (2014)	1
ATRX	7	ZBED1	0	affinity chromatography technology, pull down	Valadez-Graham V (2012), Valadez-Graham V (2012)	2
PDZK1	0	UBE2I	0	two hybrid	Gisler SM (2003)	1
ZBED1	0	UCHL5	1	two hybrid	Rolland T (2014)	1
ZBED1	0	ZBED1	0	two hybrid	Rolland T (2014)	1
MTA2	1	SPAG9	5	biochemical	Kristensen AR (2012)	1
FANCG	3	ZBED1	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
KDM1A	2	MBD3	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Wang Y (2009), Li Q (2011), Weimann M (2013)	3
RENBP	2	ZBED1	0	two hybrid	Rual JF (2005)	1
KLHL40	4	SPAG9	5	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	CREG1	0	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
ZBED1	0	MBD3	4	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	AMOTL2	5	two hybrid	Rolland T (2014)	1
DHRSX	0	ZBED1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO2	0	ZBED1	0	pull down	Ouyang J (2009)	1
UCHL5	1	KDM1A	2	two hybrid	Weimann M (2013)	1
ZBED1	0	10597	0	two hybrid, two hybrid	Rual JF (2005), Yu H (2011)	2
PRKAR1A	4	ZBED1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2A	0	ZBED1	0	biochemical	Havugimana PC (2012)	1
ATP6V1B1	4	KDM1A	2	two hybrid	Weimann M (2013)	1
ZBED1	0	GPN1	2	two hybrid	Rual JF (2005)	1
ATP6V1B1	4	ATP6V1B2	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Nylandsted J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	4
ZBED1	0	CSTF1	1	affinity chromatography technology	Huttlin EL (2017)	1
DGCR6	0	ZBED1	0	two hybrid	Corominas R (2014)	1
MLH1	6	ZBED1	0	two hybrid	Daakour S (2016)	1
ZBED1	0	TRAPPC2	0	affinity chromatography technology	Huttlin EL (2017)	1
MTA2	1	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Wang Y (2009), Li Q (2011), Cui S (2011)	5
GATAD2B	15	MTA2	1	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Feng Q (2002), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
FABP4	3	ZBED1	0	two hybrid	Vinayagam A (2011)	1
ATP6V1B1	4	ZBED1	0	biochemical	Havugimana PC (2012)	1
ZBED1	0	NUDT18	0	two hybrid	Rual JF (2005)	1
PSAP	3	ZBED1	0	two hybrid	Lim J (2006)	1
ZNF576	2	ZBED1	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKAA1	2	FANCG	3	affinity chromatography technology, affinity chromatography technology	Chun MJ (2016), Chun MJ (2016)	2
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
ZBED1	0	GATAD2B	15	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	CDK7	0	affinity chromatography technology	Huttlin EL (2017)	1
ZBED1	0	NIP7	2	two hybrid	Rual JF (2005)	1
WDFY2	3	ZBED1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KDM1A	2	ZBED1	0	two hybrid	Yu H (2011)	1
ZBED1	0	SPEF1	2	two hybrid	Rual JF (2005)	1
PSAP	3	SUMO2	0	biochemical	Havugimana PC (2012)	1
MBD3	4	MTA2	1	affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sakai H (2002), Zhang Y (1999), Zhang Y (1999), Saito M (2002), Feng Q (2001), Wang Y (2009), Havugimana PC (2012), Wan C (2015)	8
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
PRKAA1	2	ZBED1	0	two hybrid	Rolland T (2014)	1
SUMO2	0	MTA2	1	pull down	Ouyang J (2009)	1
ZBED1	0	GPSM1	1	two hybrid	Rual JF (2005)	1
PDZK1	0	ZBED1	0	affinity chromatography technology	Huttlin EL (2017)	1
TTR	0	ZBED1	0	two hybrid	Vinayagam A (2011)	1
PIAS2	2	ZBED1	0	two hybrid	Rolland T (2014)	1
ZBED1	0	GDAP2	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
ZBED1	0	C1orf109	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2