PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WDR5	2	KAT2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang YL (2008), Huttlin EL (2015), Wang YL (2008), Huttlin EL (2017)	4
PYGO2	1	TRRAP	31	pull down	Chen J (2010)	1
PYGO2	1	KAT2A	1	affinity chromatography technology, pull down	Chen J (2010), Chen J (2010)	2
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
SUPT3H	4	DDB1	6	affinity chromatography technology, affinity chromatography technology, pull down	Martinez E (2001), Martinez E (2001), Martinez E (2001)	3
PYGO2	1	PYGO2	1	affinity chromatography technology	Chen J (2010)	1
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
CTNNB1	30	ASH2L	2	pull down, pull down	Sierra J (2006), Gomes NP (2006)	2
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
CUL4A	2	RBBP5	3	affinity chromatography technology	Higa LA (2006)	1
PYGO2	1	RBBP5	3	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
NXF1	0	CTNNB1	30	affinity chromatography technology	Castello A (2012)	1
MOV10	6	PYGO2	1	affinity chromatography technology	Castello A (2012)	1
PYGO2	1	BCL9	6	affinity chromatography technology	Hoffmans R (2007)	1
MOV10	6	DCAF1	5	affinity chromatography technology	Castello A (2012)	1
SUPT3H	4	KAT2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brand M (2001), Martinez E (2001), Martinez E (2001), Liu X (2008), Kim J (2010), Holmlund T (2012), Liu X (2003)	7
WDR5	2	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Wysocka J (2005), Patel SR (2007), Mo R (2006), Dharmarajan V (2012), Zhang P (2012), Zhang P (2012), Kim JH (2014), Xu Z (2012), Huttlin EL (2015), Dias J (2014), Huttlin EL (2017), Alicea-Velazquez NL (2016), Hauri S (2016)	13
NF2	1	KAT2A	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CREBBP	29	WDR5	2	affinity chromatography technology	Koues OI (2009)	1
DDB1	6	NXF1	0	biochemical	Havugimana PC (2012)	1
KLC2	2	RBBP5	3	biochemical	Havugimana PC (2012)	1
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
PYGO2	1	WDR5	2	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
NF2	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology	Huang J (2008), Huang J (2008), Huang J (2008), Huang J (2008), Huang J (2008), Li W (2010), Li W (2010), Li W (2010), Mori T (2014), Mori T (2014), Mori T (2014), Zhou L (2015), Laulajainen M (2011), Laulajainen M (2011)	14
CTNNB1	30	KMT2D	30	pull down, pull down	Sierra J (2006), Gomes NP (2006)	2
PYGO2	1	KMT2D	30	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
NF2	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (2008), Huang J (2008), Huang J (2008), Li W (2010), Li W (2010), Zhou L (2015)	6
CUL4A	2	WDR5	2	affinity chromatography technology	Higa LA (2006)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
PYGO2	1	AKT1	1	affinity chromatography technology, pull down	Li Q (2015), Li Q (2015)	2
PYGO2	1	SUPT3H	4	pull down	Chen J (2010)	1
MOV10	6	CTNNB1	30	affinity chromatography technology	Castello A (2012)	1
DDB1	6	KAT2A	1	affinity chromatography technology, pull down, affinity chromatography technology	Martinez E (2001), Martinez E (2001), Li Y (2011)	3
CUL4A	2	CTNNB1	30	affinity chromatography technology	Tripathi R (2007)	1
MOV10	6	NF2	1	affinity chromatography technology	Castello A (2012)	1
PYGO2	1	CUL4A	2	affinity chromatography technology	Li Q (2015)	1
PYGO2	1	DDB1	6	pull down, affinity chromatography technology, affinity chromatography technology	Li Q (2015), Li Q (2015), Li Q (2015)	3
PYGO2	1	ASH2L	2	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
CTNNB1	30	TRRAP	31	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sustmann C (2008), Sierra J (2006), Sierra J (2006), Gomes NP (2006)	4
PYGO2	1	DCAF1	5	pull down	Li Q (2015)	1
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
KAT2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DDB1	6	CTNNB1	30	affinity chromatography technology	Kawajiri K (2009)	1
PYGO2	1	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology	Andrews PG (2009), Andrews PG (2009), Andrews PG (2009)	3
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
NXF1	0	NF2	1	affinity chromatography technology	Castello A (2012)	1
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
KAT2A	1	TRRAP	31	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McMahon SB (2000), Helmlinger D (2006), Meyer KD (2008), Krebs AR (2010), Kim J (2010), Kim J (2010), Liu X (2003)	7
BCL9	6	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
MOV10	6	TRIP6	2	affinity chromatography technology	Castello A (2012)	1
CTNNB1	30	KAT2A	1	pull down, affinity chromatography technology	Sierra J (2006), Chen J (2010)	2
CTNNB1	30	RBBP5	3	pull down, pull down, affinity chromatography technology	Sierra J (2006), Gomes NP (2006), Chen J (2010)	3
SUPT3H	4	TRRAP	31	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Martinez E (2001), Martinez E (2001), Wang YL (2008), Holmlund T (2012), Hein MY (2015)	5
KAT2A	1	CUL4A	2	affinity chromatography technology	Li Y (2011)	1
NXF1	0	PYGO2	1	affinity chromatography technology	Castello A (2012)	1
KMT2D	30	AKT1	1	affinity chromatography technology, enzymatic study	Toska E (2017), Toska E (2017)	2
KMT2D	30	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Patel SR (2007), Mo R (2006), Mo R (2006), Mo R (2006), Kim JH (2014), Li Y (2016), Alicea-Velazquez NL (2016)	7
KLC2	2	PYGO2	1	biochemical	Havugimana PC (2012)	1
RBBP5	3	DDB1	6	affinity chromatography technology	Higa LA (2006)	1
TRIP6	2	PYGO2	1	biochemical	Wan C (2015)	1
PYGO2	1	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
PYGO2	1	NF2	1	pull down	Chen J (2010)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
RBBP5	3	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wysocka J (2005), Patel SR (2007), Mo R (2006), Mo R (2006), Kim JH (2014), Hu D (2013), Alicea-Velazquez NL (2016)	7
CUL4A	2	NF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (2008), Huang J (2008), Li W (2010)	3