PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CLDN1	0	TJP3	8	pull down	Itoh M (1999)	1
TJP1	2	TJP3	8	affinity chromatography technology, affinity chromatography technology	Wittchen ES (1999), Wittchen ES (1999)	2
TJP2	2	TJP1	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, biochemical	Itoh M (1999), Wittchen ES (1999), Wittchen ES (1999), Wittchen ES (1999), Fanning AS (1998), Couzens AL (2013), Wan C (2015)	7
CLDN1	0	CLDN3	0	affinity chromatography technology, affinity chromatography technology	Coyne CB (2003), Coyne CB (2003)	2
CLDN1	0	DRG1	1	two hybrid	Wang J (2011)	1
LNX1	7	CLDN1	0	two hybrid	Guo Z (2012)	1
CLDN1	0	TJP2	2	pull down	Itoh M (1999)	1
TJP3	8	PATJ	5	pull down	Roh MH (2002)	1
CLDN1	0	PATJ	5	pull down	Roh MH (2002)	1
CLDN1	0	TJP1	2	pull down	Itoh M (1999)	1
CLDN3	0	TJP1	2	pull down	Itoh M (1999)	1