PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADGRB1	10	LIN7A	1	unspecified method	Stephenson JR (2013)	1
MPP3	0	LIN7A	1	two hybrid	Rolland T (2014)	1
CDA	0	MPP2	0	affinity chromatography technology	Huttlin EL (2017)	1
DLG4	11	KCNJ4	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nehring RB (2000), Leonoudakis D (2004), Inanobe A (2002), Nehring RB (2000)	4
KCNJ12	0	MPP6	3	affinity chromatography technology	Leonoudakis D (2004)	1
GOLGA2	2	LIN7A	1	two hybrid	Rolland T (2014)	1
AMOT	6	APP	1	pull down	Olah J (2011)	1
AMOT	6	MPP7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wells CD (2006), Couzens AL (2013)	3
MPP2	0	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
KCNJ4	5	LIN7A	1	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
LIN7A	1	SLC20A1	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
AMOT	6	DLG1	2	affinity chromatography technology	Sowa ME (2009)	1
ADGRB1	10	DLG1	2	unspecified method	Stephenson JR (2013)	1
LIN7A	1	GUCY1A2	2	affinity chromatography technology	Hauri S (2013)	1
MPP2	0	MPP6	3	affinity chromatography technology	Huttlin EL (2017)	1
MINDY3	3	MPP6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZYX	2	LIN7A	1	two hybrid	Rolland T (2014)	1
MPP5	2	MPDZ	6	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
CDA	0	MPP6	3	affinity chromatography technology	Huttlin EL (2017)	1
LIN7A	1	GUCY1B3	0	affinity chromatography technology	Hauri S (2013)	1
LIN7A	1	MPDZ	6	affinity chromatography technology	Hauri S (2013)	1
LIN7A	1	FAM9B	0	two hybrid	Rolland T (2014)	1
GUCY1A2	2	DLG1	2	affinity chromatography technology	Russwurm M (2001)	1
CDA	0	LIN7A	1	affinity chromatography technology	Huttlin EL (2017)	1
CADM1	3	MPP3	0	two hybrid, affinity chromatography technology, pull down	Fukuhara H (2003), Fukuhara H (2003), Fukuhara H (2003)	3
SLC20A1	2	MPP2	0	affinity chromatography technology	Huttlin EL (2017)	1
GUCY1A2	2	DLG4	11	affinity chromatography technology	Russwurm M (2001)	1
GUCY1A2	2	GUCY1B3	0	affinity chromatography technology, affinity chromatography technology	Russwurm M (2001), Huttlin EL (2017)	2
KCNJ4	5	CASK	18	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
KCNJ12	0	SNTB2	4	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7A	1	EPB41L2	2	affinity chromatography technology	Hauri S (2013)	1
NSUN2	0	LIN7A	1	affinity chromatography technology	Huttlin EL (2017)	1
MPP5	2	PATJ	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roh MH (2002), Roh MH (2002), Hauri S (2013), Huttlin EL (2017)	4
EPB41L2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
LIN7A	1	PATJ	5	affinity chromatography technology	Hauri S (2013)	1
LIN7A	1	APP	1	pull down	Olah J (2011)	1
CASK	18	SNTB2	4	affinity chromatography technology	So J (2015)	1
MPP6	3	LIN7A	1	pull down, affinity chromatography technology	Tseng TC (2001), Hauri S (2013)	2
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
LIN7A	1	SNTB2	4	affinity chromatography technology	Hauri S (2013)	1
KCNJ12	0	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
AMOT	6	MPDZ	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Sowa ME (2009), Wells CD (2006), Couzens AL (2013), Couzens AL (2013)	4
NSUN2	0	MPP6	3	affinity chromatography technology	Huttlin EL (2017)	1
MPP3	0	APP	1	pull down	Olah J (2011)	1
CASK	18	DLG4	11	affinity chromatography technology, two hybrid	Chetkovich DM (2002), Chetkovich DM (2002)	2
LIN7A	1	CADM1	3	affinity chromatography technology	Hauri S (2013)	1
KCNJ4	5	DLG1	2	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001)	3
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
MPP5	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Waaijers S (2013), Waaijers S (2013), Rolland T (2014), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	6
AMOT	6	LIN7A	1	affinity chromatography technology	Sowa ME (2009)	1
SLC20A1	2	MPP6	3	affinity chromatography technology	Huttlin EL (2017)	1
ADGRB1	10	SNTB2	4	unspecified method	Stephenson JR (2013)	1
AMOT	6	PATJ	5	affinity chromatography technology, affinity chromatography technology, bioid	Wells CD (2006), Couzens AL (2013), Couzens AL (2013)	3
LIN7A	1	MPP7	2	affinity chromatography technology	Hauri S (2013)	1
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
DLG4	11	ADGRB1	10	affinity chromatography technology, unspecified method	Lim IA (2002), Stephenson JR (2013)	2
LIN7A	1	PIP4K2B	2	affinity chromatography technology	Hauri S (2013)	1
ADGRB1	10	PATJ	5	unspecified method	Stephenson JR (2013)	1
GUCY1B3	0	APP	1	pull down	Olah J (2011)	1
LIN7A	1	CASK	18	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Rolland T (2014), Hauri S (2013)	3
LIN7A	1	PXDC1	0	affinity chromatography technology	Hauri S (2013)	1
MINDY3	3	LIN7A	1	affinity chromatography technology	Huttlin EL (2015)	1
GRIN2B	30	LIN7A	1	pull down	Jo K (1999)	1
AMOT	6	MPP5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wells CD (2006), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Huttlin EL (2017)	6
LIN7A	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
GRIN2B	30	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down	Sans N (2003), Inanobe A (2002), Irie M (1997), Niethammer M (1998), Lim IA (2002), Kornau HC (1995), Kornau HC (1995), Niethammer M (1996), Niethammer M (1996), Imamura F (2002)	10
MPP2	0	LIN7A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hauri S (2013), Huttlin EL (2017)	3
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6