Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ABCC3	8714	VEDOTIN	CHEMBL2364667		CIViC	18593940
ABCC3	8714	PACLITAXEL	CHEMBL428647		CIViC	18593940
ABCC3	8714	FLUOROURACIL	CHEMBL185		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ABCC3	rs4793665	CC	morphine	metabolism/PK	yes	Children with the CC genotype had higher levels of morphine-3-glucuronide and morphine-6-glucuronide metabolite formation compared to the CT and TT genotype.	Genotype CC is associated with increased metabolism of morphine in children as compared to genotypes CT + TT.	25155932	1184998684
ABCC3	rs4793665	C	methotrexate	metabolism/PK	yes	Concentrations refers to area under the concentration time curive (0-48hrs)	Allele C is associated with decreased concentrations of methotrexate in children with Osteosarcoma as compared to allele T.	27566582	1449188656
ABCC3	rs4148412	TT	morphine-3-glucuronide	metabolism/PK	yes	This variant was not significant in the spine surgery cohort. Increases in M6G were also observed but were not significant in either cohort. Alleles were described in paper as A and G, with AA for risk genotype.	Genotype TT is associated with increased concentrations of morphine-3-glucuronide in children with tonsillectomy as compared to genotypes CC + CT.	26810133	1450342045
ABCC3	rs4793665	CC	morphine-3-glucuronide	metabolism/PK	yes		Genotype CC is associated with increased concentrations of morphine-3-glucuronide and morphine-6-glucuronide in children with Scoliosis or tonsillectomy as compared to genotypes CT + TT.	26810133	1450342061
ABCC3	rs4793665	T	morphine	metabolism/PK	yes	Clearance of morphine decreased across the genotypes as follows: CC > CT > TT. This trend was significant in pediatric patients, while a similar but non-significant trend was seen in neonates. All subjects had been genotyped at rs72552763, rs12208357, rs34130495, rs34059508 and rs55918055 in SLC22A1 and were identified as carrying the wildtype allele at all of these locations.	Allele T is associated with decreased clearance of morphine in children as compared to allele C.	32090339	1451143980
ABCC3	rs4148416	T	methotrexate	metabolism/PK	no		Allele T is not associated with clearance of methotrexate in people with Osteosarcoma as compared to allele C.	29791011	1450045103