PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VPS37A	4	TSG101	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid	Bache KG (2004), Bache KG (2004), Stuchell MD (2004), Stefani F (2011), Agromayor M (2012), Wunderley L (2014), Rolland T (2014), Stefani F (2011), Albers M (2005)	9
ALG2	2	VPS37A	4	affinity chromatography technology	Katoh K (2005)	1
HSP90AA1	7	PTK2B	6	affinity chromatography technology	Taipale M (2012)	1
SRI	1	ALG2	2	pull down	Hansen C (2003)	1
PTPN23	7	TSG101	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), Kharitidi D (2015)	3
PTK2B	6	PDCD6IP	3	affinity chromatography technology	Schmidt MH (2003)	1
ALG2	2	VPS28	2	affinity chromatography technology	Katoh K (2005)	1
PDCD6IP	3	ALG2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007), Okumura M (2009), Okumura M (2009), Katoh K (2005), Katoh K (2005), Inuzuka T (2010), Shibata H (2008)	8
PDCD6IP	3	TSG101	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid	Kim BY (2007), Ichioka F (2007), Ichioka F (2007), von Schwedler UK (2003), Schlundt A (2009), Schlundt A (2009), Schlundt A (2009), Okumura M (2009), Katoh K (2005), Strack B (2003), Strack B (2003), Zhou X (2010), Zhou X (2010), Carlton JG (2008)	14
PTK2B	6	ALG2	2	affinity chromatography technology	Schmidt MH (2003)	1
ALG2	2	HSP90AA1	7	biochemical	Katoh K (2005)	1
ALG2	2	LAMP1	0	biochemical	Katoh K (2005)	1
HMOX2	0	ALG2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRI	1	PDCD6IP	3	biochemical	Wan C (2015)	1
PDCD6IP	3	PTPN23	7	affinity chromatography technology, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007)	2
ANXA11	0	ALG2	2	far western blotting, pull down, affinity chromatography technology	Satoh H (2002), Satoh H (2002), Inuzuka T (2010)	3
ALG2	2	SEC31A	7	affinity chromatography technology	Inuzuka T (2010)	1
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
ANXA7	0	ALG2	2	far western blotting, pull down, affinity chromatography technology	Satoh H (2002), Satoh H (2002), Inuzuka T (2010)	3
ANXA7	0	SRI	1	biochemical, far western blotting, far western blotting	Brownawell AM (1997), Brownawell AM (1997), Brownawell AM (1997)	3
ALG2	2	ALG2	2	two hybrid	Katoh K (2005)	1
ALG2	2	TSG101	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Okumura M (2009), Katoh K (2005), Katoh K (2005), Inuzuka T (2010)	4
TGOLN2	1	ALG2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CD79B	0	ALG2	2	affinity chromatography technology	Huttlin EL (2017)	1
VPS37A	4	VPS28	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bache KG (2004), Bache KG (2004), Bache KG (2004), Bache KG (2004), Stefani F (2011), Huttlin EL (2015), Huttlin EL (2017)	7
ALG2	2	SHISA5	0	pull down, affinity chromatography technology	Draeby I (2007), Draeby I (2007)	2
ALG2	2	PLSCR3	0	affinity chromatography technology, affinity chromatography technology	Shibata H (2008), Shibata H (2008)	2
PTPN23	7	ALG2	2	two hybrid, affinity chromatography technology	Ichioka F (2007), Ichioka F (2007)	2