PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
BRCA1	7	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, pull down, affinity chromatography technology, genetic interference	Aprelikova ON (1999), Fan S (2001), Fan S (2001), Fan S (2001), Yarden RI (1999), Aprelikova ON (1999), Aprelikova ON (1999), Shen JP (2017)	8
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
BRCA1	7	CASP9	6	affinity chromatography technology	Martin SA (2005)	1
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
CASP8	1	RB1	2	enzymatic study	Lemaire C (2005)	1
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
CASP9	6	BIRC8	0	pull down, two hybrid, affinity chromatography technology	Richter BW (2001), Rolland T (2014), Huttlin EL (2017)	3
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
BAX	3	CASP3	0	biochemical	Chandra D (2004)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
VCP	6	CASP9	6	affinity chromatography technology	Yu CC (2013)	1
CASP12	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
VCP	6	RNF2	1	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Cao Q (2014)	2
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
CASP2	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
BRCA1	7	ARNT	1	affinity chromatography technology, pull down, affinity chromatography technology	Kang HJ (2006), Kang HJ (2006), Kang HJ (2006)	3
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
CASP9	6	NAIP	0	far western blotting	Davoodi J (2004)	1
CASP12	1	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CASP9	6	NLRP1	5	affinity chromatography technology, affinity chromatography technology	Chu ZL (2001), Hlaing T (2001)	2
CASP9	6	JUN	0	enzymatic study	Xia Y (2013)	1
XIAP	0	NOD1	3	pull down	Krieg A (2009)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
CASP8	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pan JA (2011), Huang S (2013), Huang S (2013)	3
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
CASP7	1	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2012), Jeong WJ (2012)	2
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
CASP9	6	HSD17B4	0	two hybrid	Wang J (2011)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
CASP10	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC6	15	CASP7	1	affinity chromatography technology, enzymatic study	Bartke T (2004), Qiu XB (2005)	2
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
CASP3	0	RNF2	1	enzymatic study	Wong CK (2007)	1
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
APAF1	8	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cho DH (2004), Li P (1997), Chu ZL (2001), Hu Y (1998), Pan G (1998), Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009), Choi H (2011), Wo L (2016), Vu NT (2016)	11
PTCH1	8	CASP9	6	affinity chromatography technology	Chen XL (2014)	1
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
VCP	6	BAX	3	affinity chromatography technology	Yu CC (2013)	1
APAF1	8	CASP8	1	affinity chromatography technology	Hu Y (1998)	1
CASP9	6	MSTO1	0	two hybrid	Wang J (2011)	1
SQSTM1	0	CASP9	6	affinity chromatography technology	Huang S (2013)	1
BIRC7	0	BIRC2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
MAPK1	1	CASP9	6	enzymatic study	Allan LA (2003)	1
CASP8	1	MAPK1	1	affinity chromatography technology	Yao Z (2007)	1
BIRC7	0	CASP7	1	pull down	Kasof GM (2001)	1
CASP9	6	DCC	3	affinity chromatography technology	Forcet C (2001)	1
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
BAX	3	CYCS	0	biochemical	Chandra D (2004)	1
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
BAX	3	CASP7	1	biochemical	Chandra D (2004)	1
CYCS	0	CASP9	6	imaging technique	Chen TC (2014)	1
CYCS	0	BCL2L1	0	affinity chromatography technology, imaging technique	Kharbanda S (1997), Chen TC (2014)	2
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
ABL1	9	RB1	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Miyamura T (1997), Welch PJ (1993), Knudsen ES (1996), Knudsen ES (1996), Welch PJ (1995), Welch PJ (1995)	6
BCL2L1	0	CASP9	6	affinity chromatography technology, imaging technique	Hu Y (1998), Chen TC (2014)	2
NOD1	3	CASP9	6	affinity chromatography technology	Inohara N (1999)	1
NOD1	3	CASP2	1	affinity chromatography technology	Inohara N (1999)	1
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
APAF1	8	NLRP1	5	affinity chromatography technology, biochemical	Chu ZL (2001), Chu ZL (2001)	2
JUN	0	ARNT	1	affinity chromatography technology, affinity chromatography technology	Chang KY (2009), Chang KY (2009)	2
CASP9	6	ABL1	9	affinity chromatography technology, pull down, enzymatic study	Raina D (2005), Raina D (2005), Raina D (2005)	3
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
RB1	2	ARNT	1	affinity chromatography technology	Ge NL (1998)	1
VCP	6	MAPK1	1	affinity chromatography technology	Yu CC (2013)	1
BIRC6	15	CASP9	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hao Y (2004), Bartke T (2004), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005)	5
APAF1	8	XIAP	0	biochemical, affinity chromatography technology, affinity chromatography technology	Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009)	3
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
BIRC6	15	CASP3	0	affinity chromatography technology, pull down, enzymatic study	Bartke T (2004), Qiu XB (2005), Qiu XB (2005)	3
CYCS	0	APAF1	8	affinity chromatography technology	Zou H (1997)	1
CASP8	1	BIRC6	15	enzymatic study	Qiu XB (2005)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
CASP7	1	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
CASP10	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
BAX	3	XIAP	0	affinity chromatography technology	Gogada R (2011)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
CASP3	0	ARNT	1	enzymatic study, pull down	Suzuki H (2001), Suzuki H (2001)	2
JUN	0	RB1	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Nishitani J (1999), Nishitani J (1999), Nishitani J (1999), Nead MA (1998), Nead MA (1998)	5
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
DCC	3	CASP3	0	two hybrid, affinity chromatography technology	Forcet C (2001), Forcet C (2001)	2
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
ABL1	9	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, fluorescent resonance energy transfe	Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Morell M (2007)	6
CASP9	6	ARNT	1	enzymatic study, pull down	Suzuki H (2001), Suzuki H (2001)	2
CASP8	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
RNF34	1	CASP9	6	affinity chromatography technology	McDonald ER (2004)	1
VCP	6	CASP7	1	affinity chromatography technology	Yu CC (2013)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
ABL1	9	BCL2L1	0	affinity chromatography technology	Lasfer M (2006)	1
NOD1	3	RNF34	1	two hybrid, affinity chromatography technology, pull down	Zhang R (2014), Zhang R (2014), Zhang R (2014)	3
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
CASP12	1	CASP9	6	enzymatic study	Morishima N (2002)	1
JUN	0	ABL1	9	affinity chromatography technology, enzymatic study, affinity chromatography technology	Xie M (2010), Chen C (2008), Chen C (2008)	3
NLRP1	5	CASP2	1	affinity chromatography technology	Hlaing T (2001)	1
BAX	3	CASP9	6	biochemical	Chandra D (2004)	1
BIRC7	0	CASP3	0	pull down, affinity chromatography technology	Kasof GM (2001), Liu GH (2013)	2
CASP9	6	RNF2	1	enzymatic study	Wong CK (2007)	1
CASP9	6	BIRC7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kasof GM (2001), Vucic D (2002), Vucic D (2000), Rolland T (2014)	4
CASP3	0	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
BCL2L1	0	APAF1	8	affinity chromatography technology, affinity chromatography technology	Hu Y (1998), Pan G (1998)	2
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CRYAB	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
DCC	3	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Tcherkezian J (2010), Tcherkezian J (2010)	2
CASP9	6	RB1	2	enzymatic study	Lemaire C (2005)	1
BCL2L1	0	BAX	3	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Strobel T (1998), Zhang H (2002), Gillissen B (2003), Ren H (2011), Ren H (2011), Chinnaiyan AM (1997), Diaz JL (1997), Wang X (2009), Wang X (2009), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Tong J (2017), Huttlin EL (2017), Kim EM (2014)	17
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1