PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP3	0	MDC1	8	enzymatic study	Solier S (2011)	1
CDK2	0	PARP1	3	affinity chromatography technology	Neganova I (2011)	1
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
ZBTB16	4	CASP3	0	enzymatic study	Rho SB (2007)	1
MDM2	2	USO1	1	affinity chromatography technology	Jacob AG (2014)	1
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
CRYAB	0	CTNNB1	30	unspecified method, affinity chromatography technology, affinity chromatography technology	Ghosh JG (2007), Huang Z (2012), Huang Z (2012)	3
BIRC5	1	CASP3	0	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
CDKN1A	1	MAPK8	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Selma Dagtas A (2010), Selma Dagtas A (2010), Kim GY (2002)	3
CDK2	0	HSPE1	0	affinity chromatography technology	Neganova I (2011)	1
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
HSPD1	0	BAX	3	affinity chromatography technology	Kirchhoff SR (2002)	1
SOCS5	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SP1	0	GATA1	1	pull down	Lecuyer E (2002)	1
CASP3	0	SOCS5	0	two hybrid	Wang J (2011)	1
CDK2	0	EEF2	11	affinity chromatography technology	Neganova I (2011)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
HSPB1	2	CASP3	0	affinity chromatography technology	Gibert B (2012)	1
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
CASP3	0	STK4	1	imaging technique	Chen TC (2014)	1
CDKN1A	1	ZBTB16	4	two hybrid	Vinayagam A (2011)	1
CASP8	1	RB1	2	enzymatic study	Lemaire C (2005)	1
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
CDC42	3	MAPK9	3	imaging technique	Chen TC (2014)	1
CASP3	0	GRIPAP1	0	enzymatic study	Ye B (2000)	1
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
GMNN	0	CDH1	4	affinity chromatography technology	Tsunematsu T (2013)	1
CASP3	0	GSN	3	enzymatic study	Walsh JG (2008)	1
MAPK14	0	EEF2	11	affinity chromatography technology	Varjosalo M (2013)	1
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
PTTG1	0	BTRC	1	affinity chromatography technology	Limon-Mortes MC (2008)	1
ELAVL1	0	PAK2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP3	0	HEY2	0	affinity chromatography technology	Tan M (2006)	1
CTNNB1	30	SP1	0	affinity chromatography technology	Ponce E (2014)	1
MAPK14	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Wang J (2013)	2
HSPB1	2	PTGES3	0	two hybrid	Katsogiannou M (2014)	1
XIAP	0	BCL2	0	pull down, enzymatic study	Edison N (2017), Edison N (2017)	2
CDC42	3	CDH1	4	pull down, affinity chromatography technology	Shen Y (2008), Shen Y (2008)	2
CASP3	0	PRKDC	12	enzymatic study	Teraoka H (1996)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
IDH3B	0	CASP3	0	biochemical	Wan C (2015)	1
SP1	0	VIM	0	affinity chromatography technology	Chuang JY (2012)	1
HSPD1	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Samali A (1999), Samali A (1999), Xanthoudakis S (1999)	3
GMNN	0	CDKN1A	1	pull down	Ramachandran N (2004)	1
CASP3	0	RBX1	2	affinity chromatography technology	Tan M (2006)	1
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
MAPK14	0	RB1	2	enzymatic study, affinity chromatography technology	Delston RB (2011), Li H (2001)	2
CASP3	0	SP1	0	enzymatic study	Rickers A (1999)	1
BAX	3	CASP3	0	biochemical	Chandra D (2004)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
COPS6	0	CDK2	0	affinity chromatography technology	Bennett EJ (2010)	1
CRYAB	0	HSPB1	2	biochemical, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Kato K (1992), Kato K (1992), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003), MacIntyre DA (2008), Zhang H (2010), Delbecq SP (2012), Aquilina JA (2013), DeGrado-Warren J (2008), Huttlin EL (2015), Huttlin EL (2017)	13
STK3	1	TRAF1	0	two hybrid	Rolland T (2014)	1
CASP3	0	DFFA	0	enzymatic study, imaging technique	Walsh JG (2008), Chen TC (2014)	2
BIRC3	1	BIRC5	1	pull down	Dohi T (2004)	1
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
CASP7	1	SP1	0	enzymatic study	Rickers A (1999)	1
BIRC5	1	CASP9	6	affinity chromatography technology, imaging technique	OConnor DS (2000), Chen TC (2014)	2
HSPD1	0	EEF2	11	biochemical	Havugimana PC (2012)	1
CASP6	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
MAPK8	3	BCL2	0	enzymatic study	Kang CB (2005)	1
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
TNFSF10	2	CASP3	0	enzymatic study	Gillissen B (2013)	1
BAG3	4	CRYAB	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hishiya A (2011), Hishiya A (2011), Hishiya A (2011), Huttlin EL (2015), Huttlin EL (2017)	5
CASP7	1	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
MDC1	8	MDM2	2	unspecified method, affinity chromatography technology	Rodriguez M (2003), Inoue K (2008)	2
FBXW11	2	STK3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015)	3
ELAVL1	0	CASP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	YWHAG	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	MDC1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK9	3	MAPK8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDH1	4	BAG3	4	bioid	Guo Z (2014)	1
HEY2	0	BTRC	1	affinity chromatography technology	Tan M (2006)	1
CASP3	0	FBXW11	2	affinity chromatography technology	Tan M (2006)	1
CDK2	0	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP3	0	STAT1	1	enzymatic study	Walsh JG (2008)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
MDC1	8	PRKDC	12	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Lou Z (2004), Lou Z (2004), Lou Z (2004), Lou Z (2004)	4
GZMB	0	DFFA	0	enzymatic study	Cullen SP (2007)	1
ARNT	1	HEY2	0	two hybrid	Chin MT (2000)	1
ELAVL1	0	PRKDC	12	affinity chromatography technology	Abdelmohsen K (2009)	1
HSPB1	2	VIM	0	two hybrid	Katsogiannou M (2014)	1
CASP3	0	MAPK8	3	enzymatic study	Enomoto A (2003)	1
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
CDK2	0	CASP3	0	affinity chromatography technology	Neganova I (2011)	1
THAP11	1	GRIPAP1	0	affinity chromatography technology	Boldt K (2016)	1
PAK2	0	APP	1	pull down	Olah J (2011)	1
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
MCL1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Ding Q (2007), Ding Q (2007), Ding Q (2007)	3
CASP2	1	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Guo Y (2002)	2
EEF2	11	PAK2	0	biochemical	Kristensen AR (2012)	1
CASP7	1	SPTAN1	9	enzymatic study	Walsh JG (2008)	1
CASP3	0	ERP44	1	affinity chromatography technology	Huttlin EL (2017)	1
CASP3	0	ARMT1	0	biochemical	Wan C (2015)	1
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
SP1	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zaniolo K (2007), Zaniolo K (2007), Zaniolo K (2007)	3
CASP7	1	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2012), Jeong WJ (2012)	2
CDK2	0	YWHAG	5	affinity chromatography technology	Neganova I (2011)	1
CASP3	0	PARP1	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nicholson DW (1995), Lueschen S (1998), Walsh JG (2008), Boucher D (2012), Luo S (2010), Betin VM (2009)	6
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
YWHAG	5	DFFA	0	affinity chromatography technology	Jin J (2004)	1
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
MLH1	6	EEF2	11	two hybrid	Brieger A (2010)	1
EEF2	11	CASP7	1	biochemical	Kristensen AR (2012)	1
TRAF3	1	CFLAR	1	affinity chromatography technology	Kataoka T (2000)	1
MAPK14	0	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
CASP3	0	SPTAN1	9	enzymatic study	Walsh JG (2008)	1
BID	1	BAX	3	imaging technique	Chen TC (2014)	1
HSPD1	0	HSPE1	0	affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, biochemical	Samali A (1999), Lee KH (2002), Lee KH (2002), Havugimana PC (2012), Suzuki T (2004), Wan C (2015)	6
BIRC5	1	CDK2	0	affinity chromatography technology	OConnor DS (2000)	1
CASP2	1	BCL2	0	genetic interference	Guo Y (2002)	1
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
CRYAB	0	BCL2	0	affinity chromatography technology, affinity chromatography technology	Launay N (2010), Launay N (2010)	2
BAG3	4	YWHAG	5	affinity chromatography technology	Chen Y (2013)	1
CASP3	0	HCLS1	0	enzymatic study, enzymatic study, imaging technique	Ruzzene M (2002), Chen YR (2001), Chen TC (2014)	3
GZMB	0	CASP7	1	enzymatic study	Cullen SP (2007)	1
CASP7	1	PTGES3	0	enzymatic study, enzymatic study	Walsh JG (2008), Boucher D (2012)	2
CDKN1A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, imaging technique	Zhang Z (2004), Zhang Z (2004), Zhang Z (2004), Jin Y (2003), Jin Y (2003), Wang B (2010), Xu H (2010), Xu H (2010), Frum R (2007), Chen TC (2014)	10
USO1	1	XIAP	0	biochemical	Havugimana PC (2012)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
CASP3	0	MCL1	1	enzymatic study	Weng C (2005)	1
ZBTB16	4	GATA1	1	affinity chromatography technology, affinity chromatography technology	Labbaye C (2002), Labbaye C (2002)	2
CASP3	0	ATG4D	2	enzymatic study	Betin VM (2009)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	PARP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDH1	4	MET	7	affinity chromatography technology, affinity chromatography technology	Davies G (2001), Davies G (2001)	2
CASP8	1	ATG4D	2	enzymatic study	Betin VM (2009)	1
PAK2	0	STAT1	1	biochemical	Wan C (2015)	1
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
CASP7	1	DFFA	0	enzymatic study	Walsh JG (2008)	1
CASP3	0	GMNN	0	enzymatic study	Roukos V (2007)	1
CASP3	0	MDM2	2	enzymatic study, enzymatic study, enzymatic study, imaging technique	Chen L (1997), Pochampally R (1998), Cheng Q (2014), Chen TC (2014)	4
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
STAT1	1	CTTN	1	biochemical	Kristensen AR (2012)	1
CASP3	0	GORASP1	1	enzymatic study	Lane JD (2002)	1
GZMB	0	CASP3	0	enzymatic study, enzymatic study	Zhao T (2007), Cullen SP (2007)	2
COPS6	0	EEF2	11	affinity chromatography technology	Bennett EJ (2010)	1
RNF2	1	NDUFS1	4	affinity chromatography technology	Cao Q (2014)	1
BIRC6	15	CASP7	1	affinity chromatography technology, enzymatic study	Bartke T (2004), Qiu XB (2005)	2
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
CASP3	0	RNF2	1	enzymatic study	Wong CK (2007)	1
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
CASP3	0	DBNL	2	enzymatic study	Chen YR (2001)	1
CDK2	0	ARHGDIA	3	affinity chromatography technology	Neganova I (2011)	1
BAG3	4	BAX	3	affinity chromatography technology	Chen Y (2013)	1
HSPB1	2	ARMT1	0	two hybrid	Katsogiannou M (2014)	1
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CASP3	0	THAP11	1	two hybrid	Dejosez M (2008)	1
BAG3	4	BID	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
XIAP	0	BIRC5	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Arora V (2007), Dohi T (2004), Dohi T (2004), Pavlyukov MS (2011)	4
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
CASP3	0	BTRC	1	affinity chromatography technology	Tan M (2006)	1
CTTN	1	USO1	1	biochemical	Wan C (2015)	1
CTNNB1	30	MAPK9	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee MH (2009), Lee MH (2009), Lee MH (2009)	3
ELAVL1	0	ERP44	1	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	COPS6	0	affinity chromatography technology	Fang L (2015)	1
RNF2	1	EEF2	11	affinity chromatography technology	Cao Q (2014)	1
PRKDC	12	SP1	0	enzymatic study	Gottlieb TM (1993)	1
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
CTNNB1	30	MAPK8	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee MH (2009), Lee MH (2009), Lee MH (2009)	3
SP1	0	MAPK8	3	affinity chromatography technology, enzymatic study	Wang SA (2009), Yang HC (2014)	2
TRAF3	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013)	2
HSPB1	2	RBX1	2	two hybrid	Katsogiannou M (2014)	1
BTRC	1	STK3	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
CASP3	0	CASP3	0	x-ray crystallography	Riedl SJ (2001)	1
CASP10	1	CASP6	0	enzymatic study	Srinivasula SM (1996)	1
GZMB	0	PTGES3	0	enzymatic study	Cullen SP (2007)	1
CASP3	0	PTGES3	0	enzymatic study	Boucher D (2012)	1
MAPK14	0	PAK2	0	affinity chromatography technology	Chan PM (2008)	1
ELAVL1	0	ARNT	1	affinity chromatography technology	Abdelmohsen K (2009)	1
STAT1	1	SPTAN1	9	two hybrid	Bandyopadhyay S (2010)	1
HSPD1	0	APP	1	affinity chromatography technology, pull down	Kumar P (2007), Olah J (2011)	2
MLH1	6	SPTAN1	9	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Brieger A (2010), Brieger A (2010), Brieger A (2010), Wan C (2015)	4
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
PARP1	3	BCL2	0	pull down	Song D (2002)	1
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
GMNN	0	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
RB1	2	CDKN1A	1	affinity chromatography technology, pull down	Nakanishi M (1999), Nakanishi M (1999)	2
BIRC7	0	BIRC2	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dynek JN (2010), Oberoi-Khanuja TK (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
BAX	3	MCL1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bae J (2000), Stankiewicz AR (2009), Zhang C (2011), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Huttlin EL (2017)	7
CDKN1A	1	PARP1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010)	4
BAG3	4	PARP1	3	affinity chromatography technology	Chen Y (2013)	1
CDH1	4	SPTAN1	9	bioid	Guo Z (2014)	1
SP1	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh J (2002), Chang YC (2001), Opitz OG (2000)	3
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
CASP3	0	NDUFS1	4	enzymatic study	Ricci JE (2004)	1
CASP3	0	USO1	1	enzymatic study	Chiu R (2002)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
GSN	3	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Abedini MR (2014), Abedini MR (2014)	2
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CASP3	0	HSPE1	0	affinity chromatography technology	Samali A (1999)	1
MAPK14	0	HSPB1	2	enzymatic study	Morley SJ (2000)	1
BIRC7	0	CASP7	1	pull down	Kasof GM (2001)	1
BCL2	0	SERPINB8	1	affinity chromatography technology	Hoetelmans RW (2004)	1
BMX	0	APP	1	pull down	Olah J (2011)	1
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
CDC42	3	BIRC2	1	pull down, pull down, affinity chromatography technology, enzymatic study	Marivin A (2013), Marivin A (2013), Marivin A (2013), Murali A (2017)	4
CASP7	1	ROCK1	6	enzymatic study	Walsh JG (2008)	1
CASP6	0	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP3	0	CDH1	4	imaging technique	Chen TC (2014)	1
CTNNB1	30	CDK2	0	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
ELAVL1	0	CDC42	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKDC	12	MAPK8	3	enzymatic study	Park SJ (2001)	1
CASP9	6	DCC	3	affinity chromatography technology	Forcet C (2001)	1
BECN1	2	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BAG3	4	HSPB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Katsogiannou M (2014), Hein MY (2015)	4
CDK2	0	GMNN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
MDM2	2	EEF2	11	affinity chromatography technology	Jacob AG (2014)	1
MDM2	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang JY (2006), Yang JY (2006), Yang JY (2006), Adhikary A (2014)	4
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
BAG3	4	MCL1	1	affinity chromatography technology, affinity chromatography technology	Boiani M (2013), Boiani M (2013)	2
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
CASP3	0	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
CASP3	0	BLM	2	enzymatic study	Freire R (2001)	1
CDC42	3	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
CASP3	0	MLH1	6	imaging technique	Chen TC (2014)	1
BECN1	2	BIRC5	1	affinity chromatography technology	Hagenbuchner J (2015)	1
GORASP1	1	HSPD1	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
BTRC	1	SP1	0	pull down	Wei S (2009)	1
ZBTB16	4	PARP1	3	enzymatic study	Rho SB (2007)	1
BAG3	4	PRKDC	12	affinity chromatography technology	Chen Y (2013)	1
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
MCL1	1	BID	1	unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method	Chen L (2005), Weng C (2005), Weng C (2005), Warr MR (2011), Chipuk JE (2008), Certo M (2006)	6
CASP8	1	VIM	0	two hybrid	Stelzl U (2005)	1
BAX	3	CASP7	1	biochemical	Chandra D (2004)	1
GZMB	0	PRKDC	12	enzymatic study	Song Q (1996)	1
RNF2	1	BECN1	2	affinity chromatography technology	Xia P (2014)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
MET	7	CTNNB1	30	affinity chromatography technology	Davies G (2001)	1
CTTN	1	BTRC	1	affinity chromatography technology	Zhao J (2012)	1
CTNNB1	30	PARP1	3	affinity chromatography technology	Sato S (2005)	1
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
LSM14B	0	CASP3	0	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
PAK2	0	CDC42	3	unspecified method, pull down, pull down, two hybrid, pull down, two hybrid	Stevens WK (1999), Abo A (1998), Zhang B (1998), Bandyopadhyay S (2010), Kaerkkaeinen S (2010), Rolland T (2014)	6
CASP3	0	APP	1	imaging technique	Chen TC (2014)	1
BCL2	0	BID	1	unspecified method, unspecified method, pull down, affinity chromatography technology, biochemical, unspecified method	Chen L (2005), Real PJ (2004), Kolluri SK (2008), Chipuk JE (2008), Chipuk JE (2008), Certo M (2006)	6
MLH1	6	BLM	2	biochemical, pull down, two hybrid, far western blotting, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Langland G (2001), Langland G (2001), Langland G (2001), Langland G (2001), Freire R (2001), Pedrazzi G (2001), Pedrazzi G (2001), Pedrazzi G (2001), Dherin C (2009), Dherin C (2009), Meetei AR (2003), Meetei AR (2003)	13
MAPK14	0	CDKN1A	1	enzymatic study, affinity chromatography technology	Kim GY (2002), Kim GY (2002)	2
CASP7	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
CFLAR	1	CASP3	0	affinity chromatography technology, pull down, two hybrid	Shu HB (1997), Han DK (1997), Han DK (1997)	3
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
CASP3	0	PKN1	4	enzymatic study	Takahashi M (1998)	1
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP3	0	GLRX	0	two hybrid	Wang J (2011)	1
MAPK14	0	CASP3	0	affinity chromatography technology	Alvarado-Kristensson M (2004)	1
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
CASP6	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
BIRC5	1	MDC1	8	affinity chromatography technology, affinity chromatography technology	Capalbo G (2010), Capalbo G (2010)	2
CDH1	4	DBNL	2	bioid	Guo Z (2014)	1
CDKN1A	1	TRAF1	0	two hybrid	Rolland T (2014)	1
CDK2	0	SPTAN1	9	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
CDC42	3	MAPK8	3	imaging technique	Chen TC (2014)	1
BLM	2	PARP1	3	affinity chromatography technology	Wang J (2013)	1
PKN1	4	TRAF1	0	enzymatic study	Kato T (2008)	1
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
CASP7	1	PARP1	3	enzymatic study, enzymatic study, enzymatic study	Lueschen S (1998), Walsh JG (2008), Boucher D (2012)	3
BIRC5	1	CASP7	1	pull down, enzymatic study, pull down	Tamm I (1998), Shin S (2001), Shin S (2001)	3
TRAF3	1	USO1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), van Zuylen WJ (2012), van Zuylen WJ (2012), van Zuylen WJ (2012)	4
CASP3	0	BMX	0	enzymatic study	Wu YM (2001)	1
CASP3	0	MET	7	imaging technique	Chen TC (2014)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
CDK2	0	VIM	0	affinity chromatography technology	Neganova I (2011)	1
SP1	0	RAD51	3	affinity chromatography technology	Tapias A (2008)	1
CASP3	0	ROCK1	6	enzymatic study	Walsh JG (2008)	1
RNF2	1	VIM	0	affinity chromatography technology	Cao Q (2014)	1
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
RB1	2	ARNT	1	affinity chromatography technology	Ge NL (1998)	1
RNF2	1	CDH1	4	affinity chromatography technology	Cao Q (2014)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
KCNA10	1	CASP3	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGDIA	3	CDC42	3	affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Ewing RM (2007), Gorvel JP (1998), Bandyopadhyay S (2010), Vinayagam A (2011), Marivin A (2013), Marivin A (2013), Wan C (2015)	7
CASP3	0	GATA1	1	enzymatic study	Ribeil JA (2007)	1
FBXW11	2	BAG3	4	affinity chromatography technology	Low TY (2014)	1
CDH1	4	STAT1	1	bioid	Guo Z (2014)	1
BIRC6	15	CASP9	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hao Y (2004), Bartke T (2004), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005)	5
CRYAB	0	CDH1	4	affinity chromatography technology	Huang Z (2012)	1
CDH1	4	PAK2	0	bioid	Guo Z (2014)	1
GATA1	1	HSPB1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	de Thonel A (2010), de Thonel A (2010), de Thonel A (2010)	3
MAP3K14	1	CASP3	0	imaging technique	Chen TC (2014)	1
PKN1	4	VIM	0	two hybrid, enzymatic study, two hybrid	Matsuzawa K (1997), Matsuzawa K (1997), Rolland T (2014)	3
RB1	2	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Hsieh JK (1999), Nguyen DX (2004), Zheng Z (2012), Sdek P (2005), Delston RB (2011), Delston RB (2011), Sdek P (2004), Sdek P (2004), Xiao ZX (1995), Xiao ZX (1995), Xiao ZX (1995), Uchida C (2006), Markham D (2006), Chan HM (2001), Chan HM (2001), Zhang H (2015), Zhang H (2015), Jaenicke RU (1996)	18
CASP6	0	SP1	0	enzymatic study	Rickers A (1999)	1
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
VIM	0	SPTAN1	9	affinity chromatography technology, affinity chromatography technology	Brown MJ (2001), Brown MJ (2001)	2
CDK2	0	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Hein MY (2015)	2
CASP3	0	PAK2	0	imaging technique	Chen TC (2014)	1
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
ARMT1	0	SERPINB8	1	biochemical	Wan C (2015)	1
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
CDKN1A	1	COPS6	0	two hybrid	Vinayagam A (2011)	1
BIRC6	15	CASP3	0	affinity chromatography technology, pull down, enzymatic study	Bartke T (2004), Qiu XB (2005), Qiu XB (2005)	3
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
SP1	0	ARNT	1	pull down	Wang F (1999)	1
CASP8	1	BIRC6	15	enzymatic study	Qiu XB (2005)	1
CASP7	1	STAT1	1	enzymatic study	Walsh JG (2008)	1
BLM	2	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
PARP1	3	PRKDC	12	affinity chromatography technology	Ju BG (2006)	1
BIRC5	1	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Capalbo G (2010), Capalbo G (2010)	2
CASP6	0	TRAF1	0	enzymatic study	Leo E (2001)	1
CASP7	1	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
ELAVL1	0	CASP3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CASP10	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
MAPK14	0	SP1	0	affinity chromatography technology	Pan W (2008)	1
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
PTTG1	0	RAD51	3	genetic interference	Horlbeck MA (2018)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	CTTN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SREBF2	5	CASP3	0	enzymatic study	Wang X (1996)	1
CDK2	0	GSN	3	affinity chromatography technology	Hein MY (2015)	1
CASP8	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
CASP7	1	VIM	0	enzymatic study	Walsh JG (2008)	1
CDH1	4	HSPD1	0	affinity chromatography technology	Catimel B (2005)	1
BAG3	4	VIM	0	affinity chromatography technology	Chen Y (2013)	1
BAX	3	XIAP	0	affinity chromatography technology	Gogada R (2011)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
CASP3	0	ARNT	1	enzymatic study, pull down	Suzuki H (2001), Suzuki H (2001)	2
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
CASP7	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
BTRC	1	MCL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Dehan E (2009), Ding Q (2007), Ding Q (2007), Ding Q (2007), Ding Q (2007)	5
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP3	0	8505	0	enzymatic study	Affar EB (2001)	1
CASP2	1	MDM2	2	enzymatic study	Oliver TG (2011)	1
CASP3	0	LCMT1	0	biochemical	Wan C (2015)	1
CASP3	0	AKT3	3	imaging technique	Chen TC (2014)	1
DCC	3	CASP3	0	two hybrid, affinity chromatography technology	Forcet C (2001), Forcet C (2001)	2
MLH1	6	PRKDC	12	affinity chromatography technology	Cannavo E (2007)	1
HSPE1	0	STK3	1	two hybrid	Wang J (2011)	1
FBXW11	2	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	4
ARNT	1	PTGES3	0	pull down	Kazlauskas A (2001)	1
TRAF3	1	BIRC3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mao AP (2010), de Jong SJ (2013), Goncharov T (2013)	3
BIRC2	1	BIRC5	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dohi T (2004), Samuel T (2005), Samuel T (2005), Jung SA (2015), Jung SA (2015), Jung SA (2015)	6
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
CDC42	3	XIAP	0	affinity chromatography technology, pull down, enzymatic study, pull down	Murali A (2017), Murali A (2017), Murali A (2017), Murali A (2017)	4
BTRC	1	HSPB1	2	affinity chromatography technology	Coyaud E (2015)	1
CDC42	3	CASP3	0	imaging technique	Chen TC (2014)	1
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
CASP9	6	ARNT	1	enzymatic study, pull down	Suzuki H (2001), Suzuki H (2001)	2
CASP3	0	YWHAG	5	two hybrid	Wang J (2011)	1
CDH1	4	USO1	1	bioid	Guo Z (2014)	1
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
FBXW11	2	MDM2	2	affinity chromatography technology	Inuzuka H (2010)	1
ELAVL1	0	STK4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RAD51	3	VIM	0	two hybrid	Stelzl U (2005)	1
CASP3	0	VIM	0	enzymatic study	Walsh JG (2008)	1
CASP3	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
FBXW11	2	CASP7	1	affinity chromatography technology	Low TY (2014)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
MDM2	2	GSN	3	affinity chromatography technology	Frum R (2007)	1
CASP3	0	EEF2	11	biochemical	Wan C (2015)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
CASP3	0	CTTN	1	enzymatic study, imaging technique	Chen YR (2001), Chen TC (2014)	2
ELAVL1	0	BIRC5	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
BAG3	4	DBNL	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
BCL2	0	BECN1	2	two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liang XH (1998), Liang XH (1998), Chen D (2010), Xu C (2011), Chang NC (2010), Strappazzon F (2011), Zhou L (2013), Molejon MI (2013), Yang L (2012), Yang L (2012), Trisciuoglio D (2013), Han J (2012), Wang Y (2013), Wang Y (2013), Luciani A (2010), Luciani A (2010), Ciechomska IA (2009), Noble CG (2008), Noble CG (2008), Sun Q (2008), Rovito D (2013), Pattingre S (2005), Pattingre S (2005), Criollo A (2010), Tang D (2010), Tang D (2010), Chauhan S (2015), Rui YN (2015), Rui YN (2015), Verma N (2017), Yuan G (2014), Li X (2017)	32
BAG3	4	CASP3	0	biochemical	Wan C (2015)	1
BIRC7	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberoi-Khanuja TK (2012), Oberoi-Khanuja TK (2012), Huttlin EL (2015), Huttlin EL (2017)	4
PTTG1	0	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
SLC35A1	1	CASP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CASP6	0	APP	1	imaging technique	Chen TC (2014)	1
MDC1	8	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down	Zhang J (2005), Zhang J (2005), Zhang J (2005)	3
PRKDC	12	MAPK9	3	enzymatic study, affinity chromatography technology	Park SJ (2001), Li Y (2012)	2
BECN1	2	PRKDC	12	affinity chromatography technology	Behrends C (2010)	1
CASP3	0	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
MDM2	2	SP1	0	affinity chromatography technology, affinity chromatography technology	Zerrouqi A (2012), Zerrouqi A (2012)	2
CDK2	0	PRKDC	12	affinity chromatography technology	Neganova I (2011)	1
CASP3	0	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
TRAF1	0	HEY2	0	two hybrid	Rolland T (2014)	1
CASP3	0	BCL2	0	enzymatic study	Liang Y (2002)	1
CDK2	0	THAP11	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	EEF2	11	bioid	Guo Z (2014)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
BLM	2	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
BAG3	4	BCL2	0	affinity chromatography technology	Boiani M (2013)	1
CASP3	0	SERPINB8	1	biochemical	Wan C (2015)	1
BTRC	1	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
MAPK9	3	SPTAN1	9	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	HSPD1	0	biochemical	Kristensen AR (2012)	1
CASP3	0	CTNNB1	30	imaging technique	Chen TC (2014)	1
HSPB1	2	GRIPAP1	0	two hybrid	Katsogiannou M (2014)	1
CASP3	0	MAPK9	3	enzymatic study	Enomoto A (2003)	1
BAX	3	CASP9	6	biochemical	Chandra D (2004)	1
GZMB	0	CASP8	1	enzymatic study	Cullen SP (2007)	1
CDKN1A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
BIRC7	0	CASP3	0	pull down, affinity chromatography technology	Kasof GM (2001), Liu GH (2013)	2
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
CASP9	6	RNF2	1	enzymatic study	Wong CK (2007)	1
CASP9	6	BIRC7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kasof GM (2001), Vucic D (2002), Vucic D (2000), Rolland T (2014)	4
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
CASP3	0	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
CASP3	0	CDKN1A	1	enzymatic study, enzymatic study, enzymatic study, imaging technique	Levkau B (1998), Park JA (1998), Zhang Y (1999), Chen TC (2014)	4
STK3	1	CASP3	0	imaging technique	Chen TC (2014)	1
HSPB1	2	ARHGDIA	3	biochemical	Wan C (2015)	1
GSN	3	APP	1	pull down, affinity chromatography technology	Chauhan VP (1999), Chauhan VP (1999)	2
PAK2	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
MAPK14	0	CASP8	1	affinity chromatography technology	Alvarado-Kristensson M (2004)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
GZMB	0	BID	1	enzymatic study	Cullen SP (2007)	1
MAPK9	3	PKN1	4	biochemical	Havugimana PC (2012)	1
ARNT	1	GMNN	0	two hybrid	Wang J (2011)	1
YWHAG	5	VIM	0	affinity chromatography technology	Jin J (2004)	1
RAD51	3	BLM	2	affinity chromatography technology, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Wu L (2001), Wu L (2001), Wu L (2001), Yang Q (2004), Srivastava V (2009), Ayguen O (2008), Vizeacoumar FJ (2013)	7
CASP3	0	TRAF3	1	enzymatic study, enzymatic study	Lee ZH (2001), Leo E (2001)	2
ERP44	1	PAK2	0	biochemical	Kristensen AR (2012)	1
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
CRYAB	0	APP	1	pull down, pull down, unspecified method, x-ray crystallography, pull down	Raman B (2005), Narayanan S (2006), Shammas SL (2011), Mainz A (2015), Narayan P (2012)	5
CASP9	6	RB1	2	enzymatic study	Lemaire C (2005)	1
MLH1	6	CTTN	1	affinity chromatography technology	Hein MY (2015)	1
BECN1	2	MCL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2012), Tang Y (2012), Germain M (2011)	3
CASP3	0	BECN1	2	enzymatic study	Luo S (2010)	1
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1
VIM	0	APP	1	pull down	Olah J (2011)	1
CASP8	1	PARP1	3	enzymatic study	Betin VM (2009)	1
PTTG1	0	CASP3	0	genetic interference	Vizeacoumar FJ (2013)	1
RAD51	3	CASP3	0	imaging technique	Chen TC (2014)	1
HSPB1	2	DFFA	0	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2