PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MDM2	2	TBP	0	pull down, pull down	Leveillard T (1997), Thut CJ (1997)	2
SOX2	4	PRKAR1A	4	affinity chromatography technology	Cox JL (2013)	1
SIRT1	3	MYOD1	0	imaging technique	Amat R (2009)	1
TRIM25	5	NR2F2	4	affinity chromatography technology	Choudhury NR (2017)	1
ESR1	0	FOXO1	2	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Schuur ER (2001), Schuur ER (2001), Zhao HH (2001), Zhao HH (2001), Castoria G (2012)	5
DNMT1	5	SETD7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, enzymatic study	Esteve PO (2009), Esteve PO (2009), Esteve PO (2009), Esteve PO (2011), Esteve PO (2011)	5
CEP170	4	SETD7	2	bioid	Gupta GD (2015)	1
MYOD1	0	HIST1H3A	3	affinity chromatography technology	Mal AK (2006)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
HIST3H3	0	TAF6	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Vermeulen M (2007), Varier RA (2010), Vermeulen M (2010)	3
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
A1BG	0	SETD7	2	two hybrid	Wang J (2011)	1
MDM2	2	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017), Nihira NT (2017)	3
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
SETD7	2	TAF10	0	x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Couture JF (2006), Couture JF (2006), Kouskouti A (2004), Kouskouti A (2004), Kouskouti A (2004)	5
HIST3H3	0	TBP	0	unspecified method	Vermeulen M (2010)	1
SETD7	2	STEAP3	2	two hybrid	Wang J (2011)	1
SETD7	2	ESR1	0	unspecified method, enzymatic study, enzymatic study	Subramanian K (2008), Subramanian K (2008), Zhang X (2013)	3
MED1	4	AR	3	affinity chromatography technology, pull down	Wang Q (2002), Wang Q (2002)	2
HIST3H3	0	TAF7	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
SETD7	2	TBP	0	affinity chromatography technology	Kouskouti A (2004)	1
TP53	0	TAF6	4	pull down, affinity chromatography technology, affinity chromatography technology	Wilhelm E (2010), Wilhelm E (2010), Wilhelm E (2010)	3
SETD7	2	RELA	1	enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Yang XD (2009), Yang XD (2009), Yang XD (2009), Ea CK (2009), Li Y (2008), Levy D (2011)	6
SMURF1	4	PRKAR1A	4	affinity chromatography technology	Xie Y (2013)	1
STAT3	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang Q (2005), Zhang Q (2005), Zhang Q (2005), Xing WJ (2015)	4
MED1	4	SETD7	2	biochemical	Havugimana PC (2012)	1
TP53	0	DNMT1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Palii SS (2008), Zhang H (2013), Zhang H (2013)	3
L3MBTL1	1	SETD7	2	affinity chromatography technology, affinity chromatography technology, pull down	Kalakonda N (2008), Kalakonda N (2008), Kalakonda N (2008)	3
RELA	1	TAF6	4	pull down	Guermah M (1998)	1
SETD7	2	SETD7	2	enzymatic study	Zhang X (2013)	1
TAF10	0	TAF6	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical	Kouskouti A (2004), Demeny MA (2007), Cavusoglu N (2003), Havugimana PC (2012), Wan C (2015)	5
FAM189B	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
SETD7	2	E2F1	0	enzymatic study, enzymatic study, enzymatic study	Kontaki H (2010), Xie Q (2011), Loftus SJ (2012)	3
ESR1	0	H3F3A	1	pull down	Nalvarte I (2010)	1
SETD7	2	HIST3H3	0	enzymatic study, enzymatic study	Ko S (2011), Fang L (2014)	2
SETD7	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, pull down	Liu X (2011), Liu X (2011), Liu X (2011)	3
SIRT1	3	HIST1H3A	3	enzymatic study	Das C (2009)	1
HIST3H3	0	DPY30	1	unspecified method	Vermeulen M (2010)	1
FAM189B	2	RNF111	2	affinity chromatography technology	Huttlin EL (2017)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
SIRT1	3	DNMT1	5	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peng L (2011), Peng L (2011), Peng L (2011), OHagan HM (2011), OHagan HM (2011)	5
SMARCA4	19	HIST1H3A	3	pull down, pull down, pull down	Lavigne M (2009), Lavigne M (2009), Kouskouti A (2005)	3
DNMT1	5	E2F1	0	biochemical	Robertson KD (2000)	1
AR	3	E2F1	0	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
SMURF1	4	UBXN7	3	enzymatic study	Andrews PS (2010)	1
ZFP41	0	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
SETD7	2	RNF111	2	affinity chromatography technology	Elkouris M (2016)	1
SETD7	2	KLF4	2	enzymatic study	Fang L (2014)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
STAT3	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology, pull down	Kataoka Y (2003), Kataoka Y (2003), Kataoka Y (2003)	3
L3MBTL1	1	TP53	0	pull down, x-ray crystallography, affinity chromatography technology	West LE (2010), West LE (2010), West LE (2010)	3
MDM2	2	SMARCA4	19	unspecified method	Nicholson J (2014)	1
TP53	0	PPP1R12A	6	affinity chromatography technology	Horikawa I (2014)	1
MDM2	2	RELA	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Heyne K (2013), Heyne K (2013), Heyne K (2013)	4
SIRT1	3	RELA	1	affinity chromatography technology	Yang SR (2007)	1
SERTAD1	0	SETD7	2	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRIM25	5	STAT3	0	affinity chromatography technology	Choudhury NR (2017)	1
E2F1	0	TBP	0	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Peng J (2007), Hagemeier C (1993), Hagemeier C (1993), Pearson A (1997), Pearson A (1997)	5
TAF6	4	TAF7	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Gupta K (2017)	2
ESR1	0	MED1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Kang YK (2002), Kang YK (2002), Wada-Hiraike O (2005), Burakov D (2000), Burakov D (2000), Burakov D (2000), Burakov D (2000), Llopis J (2000), Llopis J (2000), Fujita T (2003), Fujita T (2003)	11
AR	3	SMARCA4	19	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Wang Q (2004), van de Wijngaart DJ (2009), Dai Y (2008), Lempiaeinen JK (2017)	4
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
RNF111	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
SETD7	2	MYOD1	0	pull down, affinity chromatography technology	Tao Y (2011), Tao Y (2011)	2
ESR1	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
SMURF1	4	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down	Ito I (2010), Ito I (2010), Ito I (2010)	3
FOXO1	2	SETD7	2	affinity chromatography technology	Li X (2015)	1
KLF4	2	SMARCA4	19	affinity chromatography technology	Mak AB (2010)	1
SETD7	2	SOX2	4	enzymatic study, affinity chromatography technology	Fang L (2014), Fang L (2014)	2
PRKAR1A	4	SETD7	2	two hybrid	Wang J (2011)	1
SETD7	2	AR	3	affinity chromatography technology	Ko S (2011)	1
RELA	1	AR	3	genetic interference, genetic interference	Aarnisalo P (1998), Aarnisalo P (1998)	2
FOXO1	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kitamura YI (2005), Bastien-Dionne PO (2011), Yang Y (2005), Yang Y (2005)	4
SETD7	2	HIST1H4A	0	enzymatic study, enzymatic study	Wang H (2001), Chuikov S (2004)	2
SIRT1	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, pull down	Kume S (2007), Kume S (2007), Kume S (2007)	3
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
TRIM25	5	ZFP41	0	affinity chromatography technology	Choudhury NR (2017)	1
UBXN7	3	SETD7	2	affinity chromatography technology	Raman M (2015)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
PTPN2	0	SETD7	2	affinity chromatography technology	St-Denis N (2016)	1
SETD7	2	TP53	0	enzymatic study, enzymatic study, x-ray crystallography, two hybrid	Huang J (2006), Chuikov S (2004), Chuikov S (2004), Wang J (2011)	4
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
AR	3	STAT3	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Matsuda T (2001), Ueda T (2002), Yamamoto T (2003), Yamamoto T (2003)	4
SETD7	2	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study	Couture JF (2006), Wang H (2001), Chuikov S (2004), Chuikov S (2004), Okabe J (2012)	5
SETD7	2	PPP1R12A	6	enzymatic study	Cho HS (2011)	1
TAF10	0	SMARCA4	19	affinity chromatography technology	Jeronimo C (2007)	1
TBP	0	TAF6	4	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Nakamura T (2002), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Soutoglou E (2005), Ogryzko VV (1998)	14
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
TP53	0	SMARCA4	19	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee D (2002), Lee D (2002), Lee D (2002), Napolitano MA (2007), Guan B (2011), Oh J (2008)	6
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
STAT3	0	PTPN2	0	affinity chromatography technology	Yamamoto T (2002)	1
MED1	4	MDM2	2	affinity chromatography technology, affinity chromatography technology	Lottin-Divoux S (2005), Lottin-Divoux S (2005)	2
MDM2	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang Z (2005), Zhang Z (2005), Stevens C (2008), Stevens C (2008)	4
RELA	1	TBP	0	pull down, pull down, genetic interference, affinity chromatography technology	Guermah M (1998), Schmitz ML (1995), Schmitz ML (1995), Rojo-Niersbach E (2000)	4
MDM2	2	SETD7	2	pull down	Lezina L (2015)	1
FAM189B	2	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
E2F1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Liu W (2012), Liu W (2012)	2
TBP	0	TAF10	0	biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Kouskouti A (2004), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Wieczorek E (1998), Kamileri I (2012), Havugimana PC (2012), Le Douarin B (1995)	11
TP53	0	TAF10	0	affinity chromatography technology	Gamper AM (2008)	1
TBP	0	ESR1	0	pull down, pull down	Waernmark A (2001), Lazennec G (1997)	2
FOXO1	2	SMARCA4	19	affinity chromatography technology	Li X (2015)	1
SMARCA4	19	STAT3	0	affinity chromatography technology, affinity chromatography technology, pull down	Giraud S (2004), Giraud S (2004), Giraud S (2004)	3
SETD7	2	SMURF2	3	affinity chromatography technology	Elkouris M (2016)	1
STAT3	0	SETD7	2	affinity chromatography technology, enzymatic study	Yang J (2010), Yang J (2010)	2
DPY30	1	SETD7	2	biochemical	Havugimana PC (2012)	1
MDM2	2	HIST3H3	0	pull down, enzymatic study, affinity chromatography technology	Chen L (2010), Chen L (2010), Chen L (2010)	3
H3F3A	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Lacoste N (2014)	2
DNMT1	5	HIST3H3	0	affinity chromatography technology	Qin W (2015)	1
AR	3	FOXO1	2	affinity chromatography technology, two hybrid, far western blotting	Li P (2003), Li P (2003), Li P (2003)	3
ESR1	0	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Olivier S (2006), Nettles KW (2008), Nettles KW (2008), Rubio MF (2006), Rubio MF (2006)	5
FOXO1	2	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Fu W (2009), Fu W (2009), Fu W (2009), Fu W (2009), Jang H (2016)	5
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
SIRT1	3	ESR1	0	affinity chromatography technology	Elangovan S (2011)	1
SETD7	2	SMAD7	1	enzymatic study	Elkouris M (2016)	1
AGTR1	4	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
TAF10	0	TAF7	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Jeronimo C (2007), Kouskouti A (2004), Wieczorek E (1998), Havugimana PC (2012), Gupta K (2017)	5
MYOD1	0	NR2F2	4	pull down	Bailey P (1998)	1
SETD7	2	H3F3A	1	enzymatic study	Nightingale KP (2007)	1
TRIM25	5	ARIH1	3	affinity chromatography technology	Choudhury NR (2017)	1
TBP	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Seto E (1992), Cvekl A (1999), Wu Y (2001), Qadri I (2002), Qadri I (2002), Sommer MH (1994)	6
TBP	0	TAF7	0	affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Gupta K (2017)	8
ESR1	0	MDM2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Liu G (2000), Kinyamu HK (2003), Duong V (2007), Duong V (2007), Duong V (2007), Duong V (2007), Saji S (2001), Saji S (2001)	8
SETD7	2	TAF6	4	affinity chromatography technology	Kouskouti A (2004)	1
TRIM25	5	SETD7	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SMARCA4	19	affinity chromatography technology	Choudhury NR (2017)	1
SETD7	2	SMURF1	4	affinity chromatography technology	Elkouris M (2016)	1
SIRT1	3	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fu M (2006), Fu M (2006), Fu M (2006), Fu M (2006)	4
ARIH1	3	SETD7	2	affinity chromatography technology	Huttlin EL (2017)	1
STAT3	0	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu Z (2002), Yu Z (2002), Yoshida Y (2004), Yoshida Y (2004), Dhar K (2013)	5
ESR1	0	STAT3	0	affinity chromatography technology	Wang LH (2001)	1
AR	3	MDM2	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Gaughan L (2005), Gaughan L (2005), Chymkowitch P (2011), Chymkowitch P (2011), Liu T (2012), Liu T (2012), Deep G (2008), Deep G (2008), Lin HK (2002), Lin HK (2002), Zhang A (2015), Kwegyir-Afful AK (2015), McClurg UL (2016), McClurg UL (2016), Liao Y (2017), Steely AM (2017), Zhai W (2016)	18
SIRT1	3	STAT3	0	affinity chromatography technology	Lin Z (2012)	1
AR	3	TBP	0	pull down	McEwan IJ (1997)	1
NR2F2	4	SETD7	2	two hybrid	Wang J (2011)	1
MYOD1	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Philipot O (2010), de la Serna IL (2005), Forcales SV (2012)	3
KLF4	2	RELA	1	affinity chromatography technology	Zhang XH (2012)	1
SETD7	2	SMARCA4	19	affinity chromatography technology	Okabe J (2012)	1
CCR1	0	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
HIST3H3	0	TAF10	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
ZFP41	0	ARIH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	MED1	4	affinity chromatography technology, pull down, affinity chromatography technology	Frade R (2000), Drane P (1997), Lottin-Divoux S (2005)	3
SMAD7	1	MYOD1	0	two hybrid	Colland F (2004)	1
SETD7	2	TAF7	0	affinity chromatography technology	Kouskouti A (2004)	1
SMARCA4	19	ESR1	0	two hybrid, pull down	Ichinose H (1997), DiRenzo J (2000)	2
SIRT1	3	E2F1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Pediconi N (2009), Ji W (2014), Wang C (2006), Wang C (2006)	4