PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCAS4	0	SRCIN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	BCAR1	6	affinity chromatography technology	Fei T (2017)	1
SRC	2	BCAR1	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Burnham MR (1999), Burnham MR (1999), Wei L (2002), Hsia DA (2003), Kovacic-Milivojevic B (2001), Donaldson JC (2000), Angers-Loustau A (1999), Cabodi S (2004), Modzelewska K (2006), Sawada Y (2006), Riggins RB (2006), Riggins RB (2006)	12
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
SRCIN1	3	SNAP25	8	pull down, two hybrid	Chin LS (2000), Chin LS (2000)	2
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
SRCIN1	3	SYP	0	affinity chromatography technology, affinity chromatography technology	Ito H (2008), Ito H (2008)	2
CDH1	4	CKAP5	2	bioid	Guo Z (2014)	1
NUFIP1	0	SRCIN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	SRCIN1	3	bioid	Guo Z (2014)	1
NUFIP1	0	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRCIN1	3	SORBS3	5	two hybrid, affinity chromatography technology	Ito H (2008), Ito H (2008)	2
CSK	3	SRC	2	pull down	Sabe H (1994)	1
SRC	2	SRCIN1	3	affinity chromatography technology, affinity chromatography technology, pull down	Di Stefano P (2007), Di Stefano P (2007), Di Stefano P (2007)	3
FBXO7	1	SRCIN1	3	enzymatic study	Teixeira FR (2016)	1
BCAR1	6	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Zhou B (2004), Di Stefano P (2004), Hsia DA (2003), Hsia DA (2003), Gu J (2001), Garton AJ (1999), Angers-Loustau A (1999), Qiu W (1998), Blaukat A (1999), Wang JF (2000), Holcomb M (2006), Wu Y (2005), Cho SY (2000), Modzelewska K (2006), Modzelewska K (2006), Brehme M (2009), Cho SY (2002), Cho SY (2002), Mielenz D (2001), Peterson ME (2008), Liu BA (2012), Larsson H (1999)	22
SRCIN1	3	CRK	0	affinity chromatography technology	Di Stefano P (2004)	1
SORBS3	5	SYP	0	affinity chromatography technology	Ito H (2008)	1
BCAR1	6	SRCIN1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Di Stefano P (2004), Di Stefano P (2004), Di Stefano P (2004), Di Stefano P (2004)	4
HNRNPL	3	SRCIN1	3	affinity chromatography technology	Fei T (2017)	1
SRCIN1	3	CKAP5	2	biochemical	Wan C (2015)	1
NUFIP1	0	SYP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRCIN1	3	CSK	3	affinity chromatography technology, affinity chromatography technology	Di Stefano P (2007), Di Stefano P (2007)	2
CDH1	4	SNAP25	8	bioid	Guo Z (2014)	1
FBXO7	1	SNAP25	8	enzymatic study	Teixeira FR (2016)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2