PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
CACNA1A	21	CALM2	0	two hybrid	Kahle JJ (2011)	1
UNK	3	DNM1L	3	affinity chromatography technology	Murn J (2015)	1
PPP3CB	1	CALM2	0	affinity chromatography technology	St-Denis N (2016)	1
CALM2	0	AKAP9	13	two hybrid, two hybrid	Takahashi M (2002), Takahashi M (2002)	2
CFTR	5	CALM2	0	affinity chromatography technology	Pankow S (2015)	1
CALM2	0	ADCY8	6	unspecified method, far western blotting	Gu C (1999), Gu C (1999)	2
CALM2	0	CCND2	2	pull down	Chen BB (2012)	1
CALM2	0	C11orf65	0	two hybrid	Rolland T (2014)	1
CCP110	6	CEP290	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Li J (2012), Li J (2012), Al-Hakim AK (2012), Gupta GD (2015), Gupta GD (2015)	5
CEP290	5	CEP97	0	affinity chromatography technology, affinity chromatography technology, bioid	Li J (2012), Gupta GD (2015), Gupta GD (2015)	3
MCM2	3	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
CEP104	4	CEP290	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MCM2	3	CUL4B	8	affinity chromatography technology	Drissi R (2015)	1
KCNQ2	38	CALM2	0	two hybrid	Yus-Najera E (2002)	1
CALM2	0	RPSA	2	two hybrid	Wang J (2011)	1
CEP104	4	CALM2	0	bioid	Gupta GD (2015)	1
ADRB2	0	CALM2	0	affinity chromatography technology	Roy SJ (2013)	1
MARCKS	0	CALM2	0	x-ray crystallography	Yamauchi E (2003)	1
DLST	3	CALM2	0	affinity chromatography technology	Malty RH (2017)	1
CFTR	5	MARCKS	0	affinity chromatography technology	Pankow S (2015)	1
CUL4B	8	CALM2	0	affinity chromatography technology	Bennett EJ (2010)	1
MCM2	3	CALM2	0	affinity chromatography technology	Drissi R (2015)	1
INVS	2	CALM2	0	two hybrid	Otto EA (2005)	1
CALM2	0	MRPL20	3	two hybrid	Stelzl U (2005)	1
DNM1L	3	LRRK2	5	affinity chromatography technology, affinity chromatography technology	Wang X (2012), Wang X (2012)	2
CENPJ	6	CEP97	0	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CALM2	0	IQGAP3	6	two hybrid	Rolland T (2014)	1
STK11	2	CALM2	0	two hybrid	Arroyo R (2015)	1
CEP290	5	CALM2	0	bioid	Gupta GD (2015)	1
CALM2	0	MYO6	3	two hybrid	Stelzl U (2005)	1
LRRK2	5	CALM2	0	affinity chromatography technology	Meixner A (2011)	1
CCP110	6	CEP97	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Spektor A (2007), Spektor A (2007), Spektor A (2007), Li J (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Li J (2013), Li J (2013), Gupta GD (2015), Gupta GD (2015), Boldt K (2016)	11
CUL1	7	RPSA	2	affinity chromatography technology	Bennett EJ (2010)	1
CFTR	5	DLST	3	affinity chromatography technology	Pankow S (2015)	1
CUL1	7	CALM2	0	affinity chromatography technology	Bennett EJ (2010)	1
CEP97	0	CALM2	0	bioid	Gupta GD (2015)	1
CCND2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
H2AFX	1	CALM2	0	affinity chromatography technology	Yang X (2010)	1
IQCB1	3	IQGAP3	6	affinity chromatography technology	Sang L (2011)	1
CFTR	5	MCM2	3	affinity chromatography technology	Pankow S (2015)	1
MCM2	3	RPSA	2	affinity chromatography technology	Drissi R (2015)	1
IQCB1	3	CALM2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Otto EA (2005), Otto EA (2005), Sang L (2011)	3
CAMKMT	1	CALM2	0	affinity chromatography technology	Cloutier P (2013)	1
PPEF1	1	CALM2	0	affinity chromatography technology	St-Denis N (2016)	1
CALM2	0	IQCE	3	two hybrid	Rolland T (2014)	1
UBE3A	4	CFTR	5	imaging technique, affinity chromatography technology	Mishra A (2009), Wang X (2006)	2
UBE3A	4	CALM2	0	affinity chromatography technology	Jung SY (2005)	1
CFTR	5	ADCY8	6	affinity chromatography technology	Wang X (2006)	1
ADRB2	0	PDHA1	7	affinity chromatography technology	Roy SJ (2013)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
DLST	3	MYO6	3	affinity chromatography technology	Malty RH (2017)	1
DNM1L	3	CALM2	0	affinity chromatography technology	Malty RH (2017)	1
CCND2	2	RPSA	2	affinity chromatography technology	Russo LC (2017)	1
PDHA1	7	MYO6	3	affinity chromatography technology	Malty RH (2017)	1
IQCB1	3	CEP290	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sang L (2011), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017), Boldt K (2016), Das A (2017)	6
CUL3	17	CALM2	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	PDHA1	7	affinity chromatography technology	Bennett EJ (2010)	1
PCK1	1	CALM2	0	affinity chromatography technology	Jiang W (2011)	1
UNK	3	CALM2	0	affinity chromatography technology	Murn J (2015)	1
CALM2	0	IQCN	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SCLT1	1	CALM2	0	bioid	Gupta GD (2015)	1
IQCB1	3	VAMP2	3	affinity chromatography technology	Sang L (2011)	1
STK11	2	H2AFX	1	affinity chromatography technology	So J (2015)	1
PDHA1	7	CALM2	0	affinity chromatography technology	Malty RH (2017)	1
CFTR	5	IQGAP3	6	affinity chromatography technology	Pankow S (2015)	1
USP6	1	CALM2	0	affinity chromatography technology, affinity chromatography technology, pull down	Shen C (2005), Shen C (2005), Shen C (2005)	3
CFTR	5	MYO6	3	affinity chromatography technology, affinity chromatography technology	Collaco A (2010), Pankow S (2015)	2
CALM2	0	VAMP2	3	biochemical	Havugimana PC (2012)	1
CCP110	6	CALM2	0	bioid	Gupta GD (2015)	1
PPEF2	0	CALM2	0	affinity chromatography technology	St-Denis N (2016)	1
CEP97	0	IQCB1	3	affinity chromatography technology	Boldt K (2016)	1
CALM2	0	ADAMTS12	2	two hybrid	Rolland T (2014)	1
CENPJ	6	CALM2	0	bioid	Gupta GD (2015)	1
CENPJ	6	CCP110	6	bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015)	3
KCNIP3	1	CALM2	0	two hybrid	Chang JW (2007)	1
CEP97	0	CEP104	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CALM2	0	CAMTA2	4	two hybrid	Rolland T (2014)	1
CEP104	4	CCP110	6	bioid	Gupta GD (2015)	1