PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLK1	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Lin DC (2011), Lin DC (2011)	2
UBE3A	4	JADE1	6	two hybrid, two hybrid, two hybrid	Vinayagam A (2011), Lim J (2006), Corominas R (2014)	3
TRIM25	5	JADE1	6	affinity chromatography technology	Choudhury NR (2017)	1
ING5	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Huttlin EL (2017)	3
SMN1	0	TMPO	0	affinity chromatography technology	Fuller HR (2010)	1
JADE1	6	NPHP4	10	affinity chromatography technology, affinity chromatography technology	Borgal L (2012), Borgal L (2012)	2
TMPO	0	KAT7	3	affinity chromatography technology	Hein MY (2015)	1
KAT5	1	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2004), Huttlin EL (2015), Jacquet K (2016), Huttlin EL (2017)	4
TRIM25	5	ING5	3	affinity chromatography technology	Choudhury NR (2017)	1
KAT7	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
JADE1	6	MEAF6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Saksouk N (2009), Avvakumov N (2012), Avvakumov N (2012), Huttlin EL (2017)	4
JADE1	6	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chitalia VC (2008), Chitalia VC (2008), Chitalia VC (2008)	3
KAT7	3	JADE1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Foy RL (2008), Saksouk N (2009), Avvakumov N (2012), Avvakumov N (2012), Huttlin EL (2015), Siriwardana NS (2014), Siriwardana NS (2014), Siriwardana NS (2014), Huttlin EL (2017)	10
HIST2H3C	0	KAT5	1	affinity chromatography technology, enzymatic study	Jeong KW (2011), Koiwai K (2011)	2
UBE3A	4	UBE2E1	1	pull down, two hybrid, pull down	Nuber U (1996), Kumar S (1997), Kumar S (1997)	3
JADE1	6	UBE2E1	1	pull down	Chitalia VC (2008)	1
ING4	1	HIST2H3C	0	x-ray crystallography	Palacios A (2008)	1
AKT1	1	JADE1	6	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zeng L (2013), Zeng L (2013), Zeng L (2013), Zeng L (2013)	4
SEPT8	1	JADE1	6	two hybrid	Vinayagam A (2011)	1
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
PFDN1	0	JADE1	6	two hybrid	Vinayagam A (2011)	1
SMN1	0	JADE1	6	two hybrid	Vinayagam A (2011)	1
ING4	1	JADE1	6	affinity chromatography technology, pull down, affinity chromatography technology	Doyon Y (2006), Avvakumov N (2012), Hein MY (2015)	3
KAT5	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Roe JS (2011), Roe JS (2011)	2
TRIM25	5	PLK1	0	affinity chromatography technology	Choudhury NR (2017)	1
PKD1	18	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Geng L (2000), Geng L (2000)	2
HMOX2	0	JADE1	6	two hybrid	Vinayagam A (2011)	1
CCDC94	0	JADE1	6	two hybrid	Rolland T (2014)	1
TMPO	0	JADE1	6	affinity chromatography technology	Hein MY (2015)	1
ING4	1	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Hein MY (2015), Huttlin EL (2017)	3
AKT1	1	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016)	5
KAT7	3	ING5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Huttlin EL (2017)	6
UBE3A	4	CTNNB1	30	enzymatic study, affinity chromatography technology	Kuslansky Y (2016), Kuslansky Y (2016)	2
JADE1	6	KAT5	1	affinity chromatography technology	Panchenko MV (2004)	1
JADE1	6	PLK1	0	affinity chromatography technology, imaging technique	Borgal L (2016), Borgal L (2016)	2
PKD1	18	JADE1	6	affinity chromatography technology, affinity chromatography technology	Foy RL (2012), Foy RL (2012)	2
JADE1	6	HIST2H3C	0	pull down	Saksouk N (2009)	1
ING4	1	KAT7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Culurgioni S (2012), Hein MY (2015)	6
ING5	3	JADE1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Saksouk N (2009), Avvakumov N (2012)	3
TRIM25	5	SUPT5H	2	affinity chromatography technology	Choudhury NR (2017)	1
SUPT5H	2	JADE1	6	affinity chromatography technology	Hein MY (2015)	1
VHL	0	JADE1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Zhou MI (2002), Zhou MI (2002), Zhou MI (2004), Zhou MI (2004)	4
JADE1	6	UBE2H	3	pull down	Chitalia VC (2008)	1
TK1	0	JADE1	6	two hybrid	Vinayagam A (2011)	1