PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERP44	1	FHL2	0	biochemical	Kristensen AR (2012)	1
ZNF212	1	NKX2-3	0	two hybrid	Gao J (2008)	1
ZNF3	0	FHL2	0	two hybrid	Gao J (2008)	1
FHL2	0	SAP30BP	2	two hybrid	Gao J (2008)	1
ZNF212	1	155060	0	two hybrid	Rolland T (2014)	1
ZNF212	1	ZNF331	0	two hybrid	Gao J (2008)	1
ZNF212	1	DPF2	3	two hybrid	Gao J (2008)	1
DPF2	3	FHL2	0	two hybrid, two hybrid	Gao J (2008), Gao J (2008)	2
ZNF398	1	ZNF777	3	affinity chromatography technology	Huttlin EL (2017)	1
FHL2	0	CSK	3	two hybrid	Gao J (2008)	1
ATF3	0	FHL2	0	two hybrid, two hybrid, affinity chromatography technology	Gao J (2008), Gao J (2008), Gao J (2008)	3
ZNF212	1	ZNF398	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF212	1	FHL2	0	two hybrid	Gao J (2008)	1
GNL1	1	PTP4A1	0	two hybrid	Gao J (2008)	1
ZNF212	1	ATF3	0	two hybrid	Gao J (2008)	1
ZNF331	0	ZNF408	0	two hybrid	Gao J (2008)	1
ZNF212	1	CREB3L2	0	two hybrid	Gao J (2008)	1
PTP4A1	0	CREB3L2	0	two hybrid	Gao J (2008)	1
ZNF212	1	ZNF408	0	two hybrid	Gao J (2008)	1
FHL2	0	ZNF331	0	two hybrid, two hybrid	Gao J (2008), Gao J (2008)	2
ZNF212	1	ZNF282	1	affinity chromatography technology	Huttlin EL (2017)	1
ATF4	2	ZNF212	1	two hybrid	Gao J (2008)	1
ZNF212	1	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ZNF212	1	EPDR1	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF746	0	ZNF282	1	affinity chromatography technology	Kang H (2015)	1
ZNF398	1	ZNF282	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF212	1	ZNF212	1	two hybrid, pull down	Gao J (2008), Gao J (2008)	2
ZNF212	1	PPARGC1B	2	two hybrid	Ravasi T (2010)	1
ZNF408	0	SAP30BP	2	two hybrid	Gao J (2008)	1
ZNF212	1	SF3A3	2	two hybrid	Rolland T (2014)	1
ZNF746	0	ZNF212	1	affinity chromatography technology, affinity chromatography technology	Kang H (2015), Huttlin EL (2017)	2
ERP44	1	ZNF212	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF212	1	NFKBIA	0	two hybrid	Gao J (2008)	1
ZNF212	1	ADO	1	affinity chromatography technology	Huttlin EL (2017)	1
ZNF212	1	SAP30BP	2	two hybrid	Gao J (2008)	1
ZNF212	1	FAM90A1	1	two hybrid	Rolland T (2014)	1
ZNF212	1	DUSP6	2	two hybrid	Gao J (2008)	1
NFKBIA	0	ATF4	2	two hybrid	Gao J (2008)	1
ZNF398	1	155060	0	two hybrid	Rolland T (2014)	1
ZNF212	1	CSK	3	two hybrid	Gao J (2008)	1
ZNF212	1	RND1	0	two hybrid	Gao J (2008)	1
ZNF212	1	ZNF777	3	affinity chromatography technology	Huttlin EL (2017)	1
ZNF398	1	ZNF746	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF212	1	PTP4A1	0	two hybrid	Gao J (2008)	1
ZNF212	1	GNL1	1	two hybrid	Gao J (2008)	1
ZNF212	1	ZZZ3	2	two hybrid	Ravasi T (2010)	1
ERP44	1	ZNF777	3	affinity chromatography technology	Huttlin EL (2017)	1
RND1	0	CREB3L2	0	two hybrid	Gao J (2008)	1
ZNF212	1	HBP1	1	two hybrid	Gao J (2008)	1
ZNF212	1	DIS3	2	affinity chromatography technology	Huttlin EL (2017)	1
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
FHL2	0	ZNF408	0	two hybrid, two hybrid, affinity chromatography technology	Gao J (2008), Gao J (2008), Gao J (2008)	3
ZNF212	1	ZNF3	0	two hybrid, two hybrid, pull down, pull down	Gao J (2008), Gao J (2008), Gao J (2008), Gao J (2008)	4