PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GATAD1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Varier RA (2016)	3
HDAC1	4	GATAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Vermeulen M (2010), Hein MY (2015), Varier RA (2016), Huttlin EL (2017)	5
SINHCAF	0	HDAC2	1	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	HBP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Lampert F (2018), Lampert F (2018)	7
HBP1	1	SINHCAF	0	affinity chromatography technology	Lampert F (2018)	1
RBBP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Hakimi MA (2003), Zhang Y (2002), Tong JK (1998), Sun JM (2007), Sun JM (2007), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Wan C (2015), Hauri S (2016)	14
RBBP4	3	SAP30L	0	affinity chromatography technology	Hauri S (2016)	1
FEZ1	0	SAP30L	0	two hybrid, pull down	Assmann EM (2006), Assmann EM (2006)	2
ING2	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Huttlin EL (2015), Huttlin EL (2017)	4
FOXK2	9	RBBP4	3	pull down	Shan L (2016)	1
SAP30L	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Viiri KM (2006), Joshi P (2013), Huttlin EL (2017)	3
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
SINHCAF	0	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	SINHCAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HMBOX1	2	SAP30L	0	two hybrid	Rolland T (2014)	1
HBP1	1	RBBP7	1	affinity chromatography technology	Lampert F (2018)	1
HBP1	1	ING2	0	affinity chromatography technology	Lampert F (2018)	1
SAP30L	0	HDAC3	5	affinity chromatography technology	Viiri KM (2006)	1
MXD3	1	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1
GATAD1	0	ING2	0	affinity chromatography technology	Varier RA (2016)	1
ZNF704	2	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	ING2	0	affinity chromatography technology	Li X (2015)	1
SINHCAF	0	SIN3A	13	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	MXD3	1	two hybrid, affinity chromatography technology	Meroni G (1997), Huttlin EL (2017)	2
FOXK2	9	SAP30L	0	affinity chromatography technology	Li X (2015)	1
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
HDAC1	4	HBP1	1	affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Lampert F (2018)	2
ZNF704	2	SIN3A	13	affinity chromatography technology	Huttlin EL (2017)	1
ING2	0	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1
RBBP4	3	HDAC3	5	pull down, pull down	Nicolas E (2001), Nicolas E (2001)	2
SAP30L	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Viiri KM (2006), Viiri KM (2006), Viiri KM (2006), Korkeamaeki H (2008), Bantscheff M (2011)	5
FOXK2	9	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Li X (2015), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Shan L (2016)	7
ZNF704	2	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1
SAP30L	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Viiri KM (2006), Bantscheff M (2011)	2
GATAD1	0	SIN3A	13	affinity chromatography technology	Varier RA (2016)	1
HDAC2	1	MXD1	2	affinity chromatography technology, pull down	Laherty CD (1997), Spronk CA (2000)	2
FEZ1	0	FEZ2	0	two hybrid	Assmann EM (2006)	1
ING2	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006)	2
GATAD1	0	RBBP4	3	affinity chromatography technology	Varier RA (2016)	1
FOXK2	9	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Li X (2015), Shan L (2016), Shan L (2016), Shan L (2016)	4
SINHCAF	0	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
HBP1	1	SAP30L	0	affinity chromatography technology	Lampert F (2018)	1
RBBP7	1	SAP30L	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
GATAD1	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Huttlin EL (2015), Hein MY (2015), Varier RA (2016), Huttlin EL (2017)	5
HDAC2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Adenuga D (2010), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016)	9
MXD1	2	MXD3	1	affinity chromatography technology	Cheng J (2017)	1
ING2	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
SIN3A	13	RBBP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hassig CA (1997), Zhang Y (1998), Nakamura T (2002), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Bantscheff M (2011), Hauri S (2016)	8
SINHCAF	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
SIN3A	13	MXD1	2	pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Brubaker K (2000), Ayer DE (1995), Farias EF (2010), Huttlin EL (2015), Huttlin EL (2017), Cheng J (2017)	8
ING2	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Binda O (2008), Joshi P (2013), Huttlin EL (2017)	6
ING2	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Huttlin EL (2017)	4
FEZ2	0	SAP30L	0	two hybrid	Assmann EM (2006)	1
SAP30L	0	SAP30L	0	affinity chromatography technology, pull down	Viiri KM (2006), Viiri KM (2006)	2
GATAD1	0	SINHCAF	0	affinity chromatography technology	Varier RA (2016)	1
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
RBBP7	1	SINHCAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
MXD1	2	HDAC1	4	pull down	Spronk CA (2000)	1
FOXK2	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, biochemical	Shan L (2016), Shan L (2016), Shan L (2016)	3
MXD1	2	SAP30L	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBBP7	1	FOXK2	9	affinity chromatography technology, affinity chromatography technology, pull down	Huttlin EL (2015), Huttlin EL (2017), Shan L (2016)	3
GATAD1	0	SAP30L	0	affinity chromatography technology	Varier RA (2016)	1
MXD3	1	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Ji Z (2014), Huttlin EL (2017), Shan L (2016), Shan L (2016), Shan L (2016)	5
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20
SINHCAF	0	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1