PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
RNF2	1	TRIM26	1	affinity chromatography technology	Cao Q (2014)	1
UBC	7	TRIM26	1	affinity chromatography technology	Matsumoto M (2005)	1
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
IKBKG	0	PHF7	5	pull down	Fenner BJ (2010)	1
TRIM26	1	TBK1	1	affinity chromatography technology, affinity chromatography technology	Ran Y (2016), Ran Y (2016)	2
CAND1	2	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
RNF2	1	PES1	3	affinity chromatography technology	Cao Q (2014)	1
PHF8	6	TRIM26	1	affinity chromatography technology	Hein MY (2015)	1
USP5	2	TRIM26	1	two hybrid	Hayes SD (2012)	1
ZNF223	1	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	RPS7	0	affinity chromatography technology	Cao Q (2014)	1
SUMO2	0	TRIM26	1	pull down	Ouyang J (2009)	1
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
406930	0	TRIM26	1	affinity chromatography technology	Treiber T (2017)	1
IKBKG	0	TRIM26	1	affinity chromatography technology	Ran Y (2016)	1
UBE2D1	0	RNF10	0	two hybrid	Markson G (2009)	1
CAND1	2	SRRM2	18	affinity chromatography technology	Bennett EJ (2010)	1
IFI16	1	SON	20	affinity chromatography technology	Diner BA (2015)	1
IKBKG	0	TRIM41	6	pull down	Fenner BJ (2010)	1
CEP128	1	CASK	18	bioid	Gupta GD (2015)	1
ZNF223	1	TRIM41	6	affinity chromatography technology	Huttlin EL (2017)	1
TRIM26	1	PHF10	3	affinity chromatography technology	Hein MY (2015)	1
EMSY	3	SON	20	affinity chromatography technology	Varier RA (2016)	1
HBP1	1	TRIM26	1	affinity chromatography technology	Lampert F (2018)	1
IFI16	1	USP36	4	affinity chromatography technology	Diner BA (2015)	1
IFI16	1	H2AFY2	0	affinity chromatography technology	Diner BA (2015)	1
RNF2	1	TOP1	1	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	YAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
SOX2	4	TRIM26	1	affinity chromatography technology	Cox JL (2013)	1
THAP7	0	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IFI16	1	TRIM26	1	affinity chromatography technology	Diner BA (2015)	1
UBE2D2	0	RNF126	2	two hybrid, pull down, pull down, pull down	Markson G (2009), Hou X (2012), Smith CJ (2013), Delker RK (2013)	4
SRRM2	18	HNRNPL	3	affinity chromatography technology	McCracken S (2005)	1
USP39	1	SON	20	biochemical	Havugimana PC (2012)	1
AES	2	TRIM41	6	two hybrid	Rolland T (2014)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
HNRNPL	3	TBK1	1	affinity chromatography technology	Fei T (2017)	1
ZNF169	1	TRIM41	6	affinity chromatography technology	Huttlin EL (2017)	1
TRIM26	1	RNF126	2	two hybrid	Woodsmith J (2012)	1
TRIM26	1	ARFGAP3	1	affinity chromatography technology	Hein MY (2015)	1
ZBTB38	5	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HBP1	1	SON	20	affinity chromatography technology	Lampert F (2018)	1
CEP128	1	TBK1	1	bioid	Gupta GD (2015)	1
CAND1	2	PES1	3	affinity chromatography technology	Bennett EJ (2010)	1
RABEP1	4	TRIM26	1	two hybrid	Wang J (2011)	1
SON	20	TRIM26	1	biochemical	Havugimana PC (2012)	1
CAND1	2	FBF1	2	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D2	0	RNF10	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017)	3
AES	2	TRIM26	1	two hybrid	Rolland T (2014)	1
MEPCE	1	TRIM26	1	affinity chromatography technology	Jeronimo C (2007)	1
PES1	3	SRRM2	18	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	TOP1	1	affinity chromatography technology	Depreux FF (2015)	1
HNRNPL	3	RABEP1	4	affinity chromatography technology	Fei T (2017)	1
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
LMNA	2	TRIM26	1	two hybrid	Dittmer TA (2014)	1
XPO1	8	RPS7	0	affinity chromatography technology	Kirli K (2015)	1
ORC1	3	TRIM26	1	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	RPS7	0	affinity chromatography technology	Depreux FF (2015)	1
IRF3	4	TRIM26	1	affinity chromatography technology, pull down, enzymatic study	Wang P (2015), Wang P (2015), Wang P (2015)	3
CREB3	1	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	AES	2	affinity chromatography technology	Fei T (2017)	1
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEBPD	0	TRIM26	1	affinity chromatography technology	Wang J (2010)	1
HNRNPL	3	TRIM26	1	affinity chromatography technology	Fei T (2017)	1
XPO1	8	ARFGAP3	1	affinity chromatography technology	Kirli K (2015)	1
UBE2D3	1	TRIM26	1	two hybrid	Markson G (2009)	1
KLC3	3	TRIM26	1	affinity chromatography technology	Hein MY (2015)	1
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
TRIM26	1	THAP1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
RNF2	1	TRIM41	6	affinity chromatography technology	Cao Q (2014)	1
IFI16	1	PES1	3	affinity chromatography technology	Diner BA (2015)	1
ZNF707	2	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
406930	0	HNRNPL	3	affinity chromatography technology	Treiber T (2017)	1
CEBPD	0	UBC	7	affinity chromatography technology	Balamurugan K (2013)	1
SOX2	4	MEPCE	1	affinity chromatography technology	Cox JL (2013)	1
TRIM26	1	CEP162	3	affinity chromatography technology	Hein MY (2015)	1
CAND1	2	USP39	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D1	0	TRIM26	1	two hybrid	Markson G (2009)	1
CEP128	1	TRIM26	1	bioid	Gupta GD (2015)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
CAVIN1	0	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
PHF7	5	TRIM41	6	two hybrid	Woodsmith J (2012)	1
DDRGK1	1	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	TBK1	1	affinity chromatography technology	Kirli K (2015)	1
SUMO2	0	PHF8	6	pull down	Ouyang J (2009)	1
TOP1	1	HNRNPL	3	affinity chromatography technology	Czubaty A (2005)	1
UBE2D1	0	RNF126	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
USP39	1	TRIM26	1	two hybrid	Hayes SD (2012)	1
TRIM26	1	MTCH1	0	affinity chromatography technology	Hein MY (2015)	1
SRRM2	18	TRIM26	1	affinity chromatography technology	McCracken S (2005)	1
TBK1	1	IRF3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Friedman CS (2008), Li S (2011), Li S (2011), Cui J (2012), Piao W (2009), Nakhaei P (2012), Ikeda F (2007), Ikeda F (2007), Ng MH (2011), Wang L (2012), Yang K (2006), Yang K (2006), Liu XY (2010), Liu S (2015), Liu S (2015), Freischmidt A (2015), Zhang Q (2017), Zhang Q (2017)	18
SRRM2	18	LMNA	2	affinity chromatography technology, affinity chromatography technology	McCracken S (2005), Depreux FF (2015)	2
LCA5	1	TRIM26	1	bioid	Gupta GD (2015)	1
H2AFY2	0	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
CC2D2A	3	SSX2IP	0	bioid	Gupta GD (2015)	1
CAND1	2	YAF2	1	affinity chromatography technology	Bennett EJ (2010)	1
TRIM26	1	METTL8	1	affinity chromatography technology	Hein MY (2015)	1
TRIM26	1	RNF10	0	two hybrid	Woodsmith J (2012)	1
LMNA	2	PNKP	3	two hybrid	Dittmer TA (2014)	1
YAF2	1	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM26	1	CHERP	6	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	ARFGAP3	1	bioid	Gupta GD (2015)	1
IKBKG	0	SSX2IP	0	two hybrid	Wang J (2011)	1
ZNF169	1	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
RNF2	1	UBE2D1	0	enzymatic study, two hybrid	Lee SJ (2001), Markson G (2009)	2
XPO1	8	IRF3	4	affinity chromatography technology	Kirli K (2015)	1
SSX2IP	0	TBK1	1	bioid	Gupta GD (2015)	1
SON	20	SRRM2	18	biochemical	Havugimana PC (2012)	1
PES1	3	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	RNF10	0	affinity chromatography technology	Kirli K (2015)	1
DACH2	0	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
CC2D2A	3	LMNA	2	bioid	Gupta GD (2015)	1
CAND1	2	TRIM26	1	affinity chromatography technology	Bennett EJ (2010)	1
MNAT1	0	TRIM26	1	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	RNF2	1	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Markson G (2009), Bentley ML (2011), Li Z (2006), Pan MR (2011), Zhang Y (2014), Xia P (2014), Gearhart MD (2006), McGinty RK (2014), Cao Q (2014), Gao Z (2014)	10
RNF2	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
HNRNPL	3	CASK	18	affinity chromatography technology	Fei T (2017)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
OTUB2	0	TRIM26	1	two hybrid	Hayes SD (2012)	1
PES1	3	TOP1	1	affinity chromatography technology	Kellner M (2015)	1
OTUB2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
406930	0	USP36	4	affinity chromatography technology	Treiber T (2017)	1
CC2D2A	3	TRIM26	1	bioid	Gupta GD (2015)	1
CEBPD	0	XPO1	8	affinity chromatography technology	Wang J (2010)	1
CEP128	1	TRIM41	6	bioid	Gupta GD (2015)	1
CNTRL	5	TRIM26	1	bioid	Gupta GD (2015)	1
PYHIN1	4	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
FBF1	2	TRIM26	1	bioid	Gupta GD (2015)	1
SOX2	4	XPO1	8	pull down	Baltus GA (2009)	1
TRIM26	1	CASK	18	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
SRRM2	18	RPS7	0	affinity chromatography technology	McCracken S (2005)	1
CAND1	2	RPS7	0	affinity chromatography technology	Bennett EJ (2010)	1
MEPCE	1	USP39	1	affinity chromatography technology	Jeronimo C (2007)	1
RNF2	1	SON	20	affinity chromatography technology	Cao Q (2014)	1
UBC	7	CAVIN1	0	pull down	Zhang X (2017)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
UBC	7	USP36	4	pull down	Kwasna D (2018)	1
UBE2D3	1	RNF126	2	two hybrid, two hybrid, pull down	Rual JF (2005), Markson G (2009), Delker RK (2013)	3
XPO1	8	TRIM26	1	affinity chromatography technology	Kirli K (2015)	1
TRIM41	6	ZBTB38	5	two hybrid	Rolland T (2014)	1
DCLRE1C	3	TRIM26	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
574033	0	TRIM26	1	affinity chromatography technology	Treiber T (2017)	1
LMNA	2	HNRNPL	3	affinity chromatography technology	Depreux FF (2015)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
TRIM41	6	UBE2D2	0	pull down	Chen D (2007)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TRIM26	1	TOP1	1	affinity chromatography technology	Hein MY (2015)	1
UBE2D3	1	RNF10	0	two hybrid	Markson G (2009)	1
TRIM26	1	TRIM26	1	two hybrid, two hybrid, enzymatic study	Reymond A (2001), Woodsmith J (2012), Ran Y (2016)	3
TRIM26	1	TRIM41	6	two hybrid	Woodsmith J (2012)	1
CNTRL	5	SSX2IP	0	bioid	Gupta GD (2015)	1
LCA5	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
574033	0	HNRNPL	3	affinity chromatography technology	Treiber T (2017)	1
TRIM26	1	EMSY	3	affinity chromatography technology	Hein MY (2015)	1
RPS7	0	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	H2AFY2	0	affinity chromatography technology	Fei T (2017)	1
LLGL2	4	TRIM26	1	affinity chromatography technology	Huttlin EL (2017)	1
SSX2IP	0	TRIM26	1	bioid	Gupta GD (2015)	1
FBF1	2	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MEPCE	1	CAND1	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Bennett EJ (2010)	2
UBE2D2	0	TRIM26	1	two hybrid	Markson G (2009)	1
USP36	4	TRIM26	1	two hybrid	Hayes SD (2012)	1
CAND1	2	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
AES	2	FBF1	2	two hybrid	Rolland T (2014)	1
XPO1	8	SSX2IP	0	affinity chromatography technology	Kirli K (2015)	1
TRIM26	1	PHF7	5	two hybrid	Woodsmith J (2012)	1
LLGL2	4	ZNF707	2	affinity chromatography technology	Hein MY (2015)	1
CEP162	3	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PNKP	3	TRIM26	1	affinity chromatography technology	Koch CA (2004)	1
UBC	7	RABEP1	4	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
4105	0	TRIM26	1	two hybrid	Yu H (2011)	1
RNF2	1	XPO1	8	affinity chromatography technology	Cao Q (2014)	1
MEPCE	1	XPO1	8	affinity chromatography technology	Jeronimo C (2007)	1
CNTRL	5	CEP162	3	bioid	Gupta GD (2015)	1
UBE2D1	0	CAND1	2	biochemical	You J (2001)	1