PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
CDKN2A	1	HSP90AA1	7	pull down	Souza-Rodrigues E (2007)	1
ZBTB49	5	EP300	36	affinity chromatography technology, pull down, pull down	Jeon BN (2014), Jeon BN (2014), Jeon BN (2014)	3
DNMT3A	17	ZBTB17	2	affinity chromatography technology, affinity chromatography technology	Brenner C (2005), Hervouet E (2009)	2
DIS3	2	ZBTB17	2	two hybrid	Lehner B (2004)	1
MYC	2	MYCN	2	affinity chromatography technology	Li X (2015)	1
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
CDKN2A	1	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Herkert B (2010), Amente S (2007), Zhang Q (2013), Ivanov AA (2017)	4
ITGB5	3	ZBTB17	2	two hybrid	Zhang H (2002)	1
BCL6	6	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Cerchietti LC (2009), Cerchietti LC (2009)	2
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
EP300	36	MAX	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Faiola F (2007), Faiola F (2005), Faiola F (2005), Zhang K (2005)	4
YWHAQ	0	HSPB1	2	affinity chromatography technology, two hybrid	Pozuelo-Rubio M (2010), Katsogiannou M (2014)	2
KLF5	4	TP53	0	affinity chromatography technology, affinity chromatography technology	Zhu N (2006), Zhu N (2006)	2
HSP90AA1	7	ZBTB17	2	affinity chromatography technology	Taipale M (2012)	1
KLF5	4	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyamoto S (2003), Matsumura T (2005), Guo P (2009), Guo P (2009), Nagai R (2005)	5
ZBTB17	2	MAGEA4	0	affinity chromatography technology, affinity chromatography technology	Sakurai T (2004), Sakurai T (2004)	2
HUWE1	22	HSP90AA1	7	affinity chromatography technology	Thompson JW (2014)	1
KLF5	4	HCFC1	4	affinity chromatography technology	Qin J (2015)	1
EP300	36	ZBTB17	2	affinity chromatography technology	Staller P (2001)	1
DACT1	3	ZBTB17	2	affinity chromatography technology, affinity chromatography technology	Huang Y (2015), Huang Y (2015)	2
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
ZBTB17	2	MAX	0	pull down	Staller P (2001)	1
DNMT3A	17	MYC	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brenner C (2005), Brenner C (2005), Brenner C (2005), Brenner C (2005), Hervouet E (2009)	5
ZBTB17	2	IRF8	4	two hybrid	Alter-Koltunoff M (2003)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
MYCN	2	MAX	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, protein complementation assay	Blackwood EM (1991), FitzGerald MJ (1999), Kim J (2010), Amente S (2007), Zhao X (2008), Zhao X (2008), Cheng J (2017), Wenzel A (1991), Wenzel A (1991), Wenzel A (1991), Mueller I (2014)	11
ZBTB17	2	MYC	2	pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staller P (2001), Peukert K (1997), Peukert K (1997), Peukert K (1997), Herold S (2008), Si J (2010), Si J (2010), Gordan JD (2007), Gordan JD (2007), Hervouet E (2009), Hervouet E (2009), Patel JH (2006), Patel JH (2006), Staller P (2001), Vo BT (2016), Vo BT (2016)	16
TP53	0	ZBTB17	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miao L (2010), Miao L (2010), Lee KM (2012)	3
HSPB1	2	HSP90AA1	7	two hybrid	Katsogiannou M (2014)	1
HUWE1	22	ZBTB17	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Lee CK (2015), Lee CK (2015)	4
HSPB1	2	ZBTB17	2	two hybrid	Katsogiannou M (2014)	1
MYC	2	ITGB5	3	genetic interference	Toyoshima M (2012)	1
HCFC1	4	HSP90AA1	7	affinity chromatography technology	Wysocka J (2003)	1
ZBTB17	2	BCL6	6	imaging technique, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Phan RT (2005), Phan RT (2005), Lee KM (2012), Lee KM (2012)	4
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
ZBTB17	2	YWHAQ	0	affinity chromatography technology	Hervouet E (2009)	1
HUWE1	22	HSPB1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Thompson JW (2014), Katsogiannou M (2014), Katsogiannou M (2014)	3
HUWE1	22	MYC	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adhikary S (2005), Adhikary S (2005), Adhikary S (2005), Koch HB (2007), Fan L (2015), Zhao X (2008)	6
EP300	36	BCL6	6	enzymatic study, affinity chromatography technology	Bereshchenko OR (2002), Bereshchenko OR (2002)	2
ZBTB7C	0	ZBTB17	2	affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Lee KM (2012), Lee KM (2012), Lee KM (2012), Lee KM (2012), Lee KM (2012)	5
ZBTB4	6	ZBTB17	2	affinity chromatography technology, affinity chromatography technology	Weber A (2008), Weber A (2008)	2
DVL2	5	DACT1	3	affinity chromatography technology, affinity chromatography technology	Huang Y (2015), Chen H (2011)	2
TMPRSS11A	1	ZBTB17	2	two hybrid, pull down	Zhao N (2004), Zhao N (2004)	2
MYC	2	MAX	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), McMahon SB (2000), McMahon SB (1998), Cheng SW (1999), Mac Partlin M (2003), Mac Partlin M (2003), Blackwood EM (1991), Lee CM (2002), Billin AN (1999), Gupta K (1998), Meroni G (1997), Nair SK (2003), Nair SK (2003), FitzGerald MJ (1999), Meroni G (2000), Hatakeyama S (2005), Bandyopadhyay S (2010), Matsuoka Y (2009), Cowling VH (2006), Wang Z (2006), Faiola F (2005), Siegel PM (2003), Veldman T (2003), Patel JH (2004), Liu T (2007), Zhang Y (2007), Gordan JD (2007), Gordan JD (2007), Gargano B (2007), Zippo A (2007), Zippo A (2007), Zhang P (2010), Kim J (2010), Kim J (2010), Kim J (2010), Kim J (2010), Koch HB (2007), Koch HB (2007), Patel JH (2006), Lavigne P (1998), Amente S (2007), Ayer DE (1993), Huang Z (2004), Huang Z (2004), Okano HJ (1999), Agrawal P (2010), Agrawal P (2010), Wong WJ (2013), Wang J (2011), Yu L (2009), Liu X (2003), Hein MY (2015), Li X (2015), Li X (2015), Kalkat M (2014), Hauri S (2016)	56
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
ZBTB17	2	ZBTB17	2	x-ray crystallography, affinity chromatography technology	Stead MA (2007), Lee KM (2012)	2
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
MYC	2	HSPB1	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
HCFC1	4	ZBTB17	2	two hybrid, affinity chromatography technology, pull down, pull down	Piluso D (2002), Piluso D (2002), Piluso D (2002), Piluso D (2002)	4
GFI1	0	ZBTB17	2	affinity chromatography technology, pull down, affinity chromatography technology	Basu S (2009), Basu S (2009), Basu S (2009)	3
HSP90AA1	7	MAX	0	affinity chromatography technology	Taipale M (2012)	1
TP53	0	BCL6	6	pull down	Kotlyar M (2015)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
ZBTB49	5	ZBTB17	2	fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology	Jeon BN (2014), Jeon BN (2014), Jeon BN (2014), Jeon BN (2014)	4
ZBTB17	2	KLF5	4	affinity chromatography technology	Guo P (2009)	1
MYCN	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology	Amente S (2007), Amente S (2007)	2
ZBTB17	2	TOPBP1	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herold S (2002), Herold S (2002), Herold S (2002), Herold S (2002), Liu K (2006), Herold S (2008)	6
DVL2	5	ZBTB17	2	affinity chromatography technology, affinity chromatography technology	Huang Y (2015), Huang Y (2015)	2
MYCN	2	HUWE1	22	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008), Zhao X (2008)	5
HSP90AA1	7	ZBTB49	5	affinity chromatography technology	Taipale M (2012)	1
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
MYCN	2	ZBTB17	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Akter J (2011), Akter J (2011), Iraci N (2011), Iraci N (2011)	4
CDKN2A	1	ZBTB17	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Miao L (2010), Miao L (2010), Miao L (2010)	3