PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TMPO	0	HDAC3	5	two hybrid, pull down, affinity chromatography technology	Somech R (2005), Somech R (2005), Somech R (2005)	3
AKAP8L	1	TMPO	0	affinity chromatography technology, affinity chromatography technology, pull down	Martins SB (2000), Martins S (2003), Martins S (2003)	3
XRCC5	5	TMPO	0	affinity chromatography technology, affinity chromatography technology	Sand-Dejmek J (2011), Brady GF (2018)	2
TMPO	0	RRBP1	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Brady GF (2018)	2
USP7	14	LMNA	2	affinity chromatography technology	Bhattacharya S (2015)	1
BANF1	0	LMNA	2	affinity chromatography technology, affinity chromatography technology	Montes de Oca R (2009), Depreux FF (2015)	2
ILF3	5	TMPO	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Brady GF (2018)	2
LMNA	2	LMNB1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ostlund C (2001), Liu GH (2011), Ju WN (2009), Roux KJ (2012), Wang J (2011), Dittmer TA (2014), Depreux FF (2015), Dou Z (2015)	8
ILF3	5	RRBP1	7	biochemical	Havugimana PC (2012)	1
YWHAE	0	TMPO	0	affinity chromatography technology, affinity chromatography technology	Zuo S (2010), Brady GF (2018)	2
TMPO	0	BANF1	0	two hybrid, pull down, biochemical	Furukawa K (1999), Furukawa K (1999), Havugimana PC (2012)	3
LMNA	2	ILF3	5	affinity chromatography technology	Depreux FF (2015)	1
TMPO	0	LMNB1	1	two hybrid, pull down, pull down, affinity chromatography technology	Furukawa K (1998), Furukawa K (1998), Foisner R (1993), Hein MY (2015)	4
TMPO	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Brady GF (2018), Brady GF (2018)	2
TMPO	0	OIP5	1	two hybrid, affinity chromatography technology	Naetar N (2007), Naetar N (2007)	2
USP7	14	TMPO	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Hein MY (2015), Brady GF (2018)	3
PFKP	5	TMPO	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TMPO	0	LMNA	2	affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, bioid, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Markiewicz E (2002), Dechat T (2000), Dechat T (2000), Dechat T (2000), Dechat T (2000), Ju WN (2009), Roux KJ (2012), Kim DI (2014), Hein MY (2015), Dittmer TA (2014), Brady GF (2018), Brady GF (2018)	12
ILF3	5	LMNB1	1	biochemical	Havugimana PC (2012)	1