Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HNF1A 6927 NORLEUCINE CHEMBL292439 DrugBank 10592235

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HNF1A rs2464196 A metformin efficacy no The authors evaluated whether women with PCOS would respond to one year of treatment with metformin either with or without oral contraception. Although there was an overall improvement in metabolic measures in subjects due to metformin, this response was not associated with any genetic variant investigated. Allele A is not associated with response to metformin in women with Polycystic Ovary Syndrome as compared to allele G. 28834135 1449147171
HNF1A rs1169288 A metformin efficacy no The authors evaluated whether women with PCOS would respond to one year of treatment with metformin either with or without oral contraception. Although there was an overall improvement in metabolic measures in subjects due to metformin, this response was not associated with any genetic variant investigated. Allele A is not associated with response to metformin in women with Polycystic Ovary Syndrome as compared to allele C. 28834135 1449147153