PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FERD3L	0	HEXIM2	0	affinity chromatography technology	Huttlin EL (2017)	1
FERD3L	0	TCF3	7	affinity chromatography technology	Huttlin EL (2017)	1
MYOG	1	TCF4	26	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MESP2	3	TCF4	26	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF14	2	TCF3	7	affinity chromatography technology	Wu B (2013)	1
CTBP1	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Hamada F (2004), Huard CC (2014)	2
ID2	0	TCF12	14	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Mathas S (2009), Lee SB (2016), Huttlin EL (2017)	4
TCF21	0	TCF12	14	two hybrid, affinity chromatography technology, affinity chromatography technology	Arab K (2011), Arab K (2011), Arab K (2011)	3
TCF4	26	ID4	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TRIM33	4	TCF4	26	affinity chromatography technology, affinity chromatography technology	Bai X (2010), Li X (2015)	2
ID2	0	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
TCF4	26	FERD3L	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TRIM33	4	TAL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bai X (2010), Bai X (2010), Bai X (2010)	3
PSEN1	11	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tesco G (1998), Kang DE (1999), Murayama M (1998), Prager K (2007), Prager K (2007), Prager K (2007), Serban G (2005), Raurell I (2006), Raurell I (2006)	9
TRIM33	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xue J (2015), Xue J (2015), Xue J (2015)	3
TCF4	26	SGF29	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
TCF21	0	TCF3	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Arab K (2011), Arab K (2011), Arab K (2011)	3
TWIST1	0	TCF4	26	pull down, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Li X (2015), Huttlin EL (2017)	3
SGF29	0	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CBFA2T3	3	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Lindberg SR (2003), Hoogeveen AT (2002)	2
TCF4	26	TWIST2	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TCF3	7	ID4	1	affinity chromatography technology	Teachenor R (2012)	1
ID3	0	TCF4	26	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Chen B (1997), Chen B (1997), Langlands K (1997), Rolland T (2014), Li X (2015), Huttlin EL (2017)	6
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TCF3	7	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, pull down	Goardon N (2006), Goardon N (2006), Goardon N (2006)	3
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
TAL2	1	TCF12	14	two hybrid	Ravasi T (2010)	1
TRIM33	4	TCF12	14	affinity chromatography technology	Bai X (2010)	1
TCF4	26	PIAS4	5	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Ihara M (2005), Ihara M (2005), Yamamoto H (2003)	4
PSEN1	11	TCF4	26	affinity chromatography technology, pull down	Raurell I (2006), Raurell I (2006)	2
CTNNB1	30	RNF14	2	affinity chromatography technology	Wu B (2013)	1
MESP2	3	TCF3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
RUNX1T1	1	GSE1	14	two hybrid	Rolland T (2014)	1
MESP2	3	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hsu HL (1994), Hsu HL (1994), Hu X (2009)	7
NEUROD1	0	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYOG	1	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM33	4	RUNX1T1	1	affinity chromatography technology	Bai X (2010)	1
RUNX1T1	1	TCF12	14	affinity chromatography technology, pull down	Zhang J (2004), Zhang J (2004)	2
TCF21	0	TCF4	26	two hybrid, affinity chromatography technology, affinity chromatography technology	Arab K (2011), Arab K (2011), Arab K (2011)	3
TCF3	7	ID3	0	two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Deed RW (1998), Deed RW (1998), Langlands K (1997), Teachenor R (2012), Rolland T (2014), Langlands K (1997)	6
TAL1	0	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goardon N (2006), Goardon N (2006), Goardon N (2006), Goardon N (2006), Hu X (2009)	5
ID1	0	TCF12	14	two hybrid, affinity chromatography technology	Langlands K (1997), Hein MY (2015)	2
TCF4	26	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TAL1	0	TCF4	26	pull down, affinity chromatography technology, two hybrid	Goldfarb AN (1996), Goardon N (2006), Langlands K (1997)	3
CTBP1	2	TCF4	26	two hybrid, two hybrid	Ravasi T (2010), Corominas R (2014)	2
TCF12	14	TCF3	7	affinity chromatography technology	Yoon SJ (2011)	1
MYOG	1	TCF12	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ID2	0	TCF3	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Teachenor R (2012), Mathas S (2009), Langlands K (1997), Lee SB (2016), Huttlin EL (2017)	6
ID3	0	TCF12	14	two hybrid, two hybrid	Langlands K (1997), Rolland T (2014)	2
TP53	0	TCF4	26	pull down, affinity chromatography technology	Kotlyar M (2015), Li X (2015)	2
TCF4	26	CBFA2T3	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TCF4	26	HEXIM2	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TCF4	26	ID1	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Massari ME (1998), Langlands K (1997), Wang J (2011), Li X (2015), Huttlin EL (2017)	5
TCF12	14	TWIST2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TCF3	7	MYOG	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Chakraborty T (1992), Huttlin EL (2015), Brennan TJ (1990), Huttlin EL (2017)	5
ASCL1	0	TCF4	26	pull down, two hybrid	Persson P (2000), Persson P (2000)	2
TP53	0	TWIST1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Shiota M (2008), Shiota M (2008), Piccinin S (2012), Piccinin S (2012), Kotlyar M (2015)	5
TAL1	0	TCF12	14	affinity chromatography technology, affinity chromatography technology	Goardon N (2006), Hu X (2009)	2
TCF3	7	GSE1	14	affinity chromatography technology	Teachenor R (2012)	1
ID1	0	TCF3	7	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Sun R (2009), Sun R (2009), Teachenor R (2012), Langlands K (1997), Hein MY (2015)	6
FERD3L	0	TCF12	14	affinity chromatography technology	Huttlin EL (2017)	1
RNF14	2	TCF4	26	affinity chromatography technology, affinity chromatography technology	Wu B (2013), Wu B (2013)	2
TCF4	26	ID2	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Goldfarb AN (1996), Massari ME (1998), Langlands K (1997), Li X (2015), Huttlin EL (2017)	6
RUNX1T1	1	TAL2	1	two hybrid	Ravasi T (2010)	1
TCF4	26	GSE1	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
NEUROD1	0	TCF4	26	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCF3	7	TCF24	2	affinity chromatography technology	Teachenor R (2012)	1
TRIM33	4	CBFA2T3	3	affinity chromatography technology	Bai X (2010)	1
TRIM33	4	TCF3	7	affinity chromatography technology	Bai X (2010)	1
TWIST1	0	TWIST2	0	affinity chromatography technology	Fu J (2011)	1
NEUROD1	0	TCF3	7	affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Kim JY (2004), Huttlin EL (2017)	3
TCF12	14	HEXIM2	0	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Huttlin EL (2017)	3
TCF4	26	TCF24	2	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TWIST1	0	TCF3	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	El Ghouzzi V (2000), El Ghouzzi V (2000), Fu J (2011), Teachenor R (2012)	4
TCF4	26	TAL2	1	two hybrid, two hybrid	Langlands K (1997), Rolland T (2014)	2
RUNX1T1	1	TCF3	7	affinity chromatography technology	Zhang J (2004)	1
CTNNB1	30	TCF4	26	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fasolini M (2003), Li Q (2004), Poy F (2001), Iguchi H (2007), Notani D (2010), Tran H (2008), Sanchez-Tillo E (2011), Selbach M (2006), Hamada F (2004), Hamada F (2004), Ponce E (2014), Wu B (2013), Wu B (2013), Yamamoto H (2003), Xu X (2014), Levy L (2004), Levy L (2004), Levy L (2004), Wang H (2008), Jansson EA (2005), Kotlyar M (2015), Zhu Z (2014), Lu D (2012), Lu D (2012), Lee HK (2007)	25