PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
ELOB	1	ELOA	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Aso T (1995), Kamura T (2002), Mahrour N (2008), Aso T (2000), Duan DR (1995), Weems JC (2015)	6
TRIM54	1	GMCL1	0	two hybrid	Rolland T (2014)	1
YWHAZ	1	ELOA	3	imaging technique	Zippo A (2009)	1
PSMB9	0	POLR2H	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
LMNA	2	FAM9B	0	two hybrid	Dittmer TA (2014)	1
CUL3	17	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
POLR2F	1	POLR2H	0	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
CUL5	1	POLR2I	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
LEO1	3	POLR2G	0	affinity chromatography technology	Hein MY (2015)	1
PLK4	1	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
ELOA	3	POLR2F	1	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
NEDD8	0	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	5430	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Krum SA (2003), Scully R (1997), Scully R (1997), Chiba N (2001), Chiba N (2001), Krum SA (2003), Starita LM (2005), Woods NT (2012), Bennett CB (2008), Hill SJ (2014), Winton CE (2016)	11
YWHAZ	1	KAT8	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
PSMB9	0	ELOA	3	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
RPGRIP1L	2	ELOA	3	affinity chromatography technology	Gupta GD (2015)	1
CUL5	1	5430	0	affinity chromatography technology	Bennett EJ (2010)	1
ECT2	2	YWHAZ	1	affinity chromatography technology	Woods NT (2012)	1
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
POLR2J	0	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2004)	2
ELOA	3	NEDD8	0	affinity chromatography technology	Weems JC (2015)	1
POLR2D	0	POLR2G	0	pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Schaller S (1999), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
POLR2F	1	POLR2E	0	pull down, biochemical, affinity chromatography technology	Acker J (1997), Wan C (2015), Hein MY (2015)	3
BRCA1	7	POLR2H	0	enzymatic study, enzymatic study	Wu W (2007), Vittal V (2015)	2
RAP1A	1	ELOA	3	pull down	Stoletov KV (2004)	1
ELOA	3	CEP70	1	two hybrid	Rolland T (2014)	1
POLR2B	3	POLR2G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
SPERT	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
POLR2B	3	POLR2E	0	pull down, pull down, biochemical, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Wan C (2015)	4
POLR2C	0	CTR9	10	affinity chromatography technology, affinity chromatography technology	Nordick K (2008), Hein MY (2015)	2
POLR2C	0	POLR2H	0	pull down, pull down, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Ayguen O (2008), Wan C (2015)	4
MDFI	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
BRCA1	7	YWHAE	0	affinity chromatography technology	Ertych N (2016)	1
ELOA	3	TRIM54	1	two hybrid	Rolland T (2014)	1
SOCS1	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang JG (1999), Nie L (2011), Qiu X (2012)	3
NTRK1	1	YWHAE	0	affinity chromatography technology	Emdal KB (2015)	1
POLR2D	0	POLR2H	0	pull down	Schaller S (1999)	1
PSMB9	0	POLR2L	1	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
SLC13A2	2	ELOA	3	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	POLR2B	3	affinity chromatography technology	Bennett EJ (2010)	1
ELOC	0	ASB9	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ravasi T (2010), Kwon S (2010), Lievens S (2009), Debrincat MA (2007), Debrincat MA (2007), Muniz JR (2013), Thomas JC (2013), Andresen CA (2014), Huttlin EL (2015), Huttlin EL (2017)	10
ASB9	0	ELOA	3	affinity chromatography technology, affinity chromatography technology	Debrincat MA (2007), Debrincat MA (2007)	2
POLR2E	0	POLR2L	1	pull down, pull down, biochemical, affinity chromatography technology	Acker J (1997), Acker J (1997), Wan C (2015), Huttlin EL (2017)	4
ELOA	3	POLR2J	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
POLR2C	0	POLR2K	0	pull down, pull down, biochemical	Acker J (1997), Acker J (1997), Wan C (2015)	3
CDK12	3	ELOA	3	biochemical	Havugimana PC (2012)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
FAM9B	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
POLR2I	0	POLR2K	0	biochemical	Wan C (2015)	1
POLR2C	0	POLR2I	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PSMB9	0	POLR2I	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
NEDD8	0	ELOC	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
PSMB9	0	POLR2K	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
PSMB9	0	POLR2B	3	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
PSMB9	0	POLR2J	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
POLR2K	0	POLR2E	0	pull down, biochemical	Acker J (1997), Wan C (2015)	2
POLR2K	0	POLR2G	0	pull down	Acker J (1997)	1
POLR2G	0	POLR2F	1	pull down, affinity chromatography technology, affinity chromatography technology	Acker J (1997), Huttlin EL (2015), Hein MY (2015)	3
LZTS2	4	ELOA	3	affinity chromatography technology	Huttlin EL (2017)	1
MID2	1	GMCL1	0	two hybrid	Rolland T (2014)	1
POLR2D	0	POLR2L	1	pull down, two hybrid, affinity chromatography technology	Schaller S (1999), Wang J (2011), Huttlin EL (2017)	3
5430	0	LEO1	3	pull down, pull down	Kim J (2010), Kim J (2010)	2
POLR2L	1	POLR2G	0	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Acker J (1997), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
NTRK1	1	CUL5	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CTR9	10	affinity chromatography technology	Emdal KB (2015)	1
MED26	2	POLR2F	1	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
ELOC	0	ELOA	3	pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Aso T (1995), Mahrour N (2008), Aso T (2000), Pause A (1999), Pause A (1999), Duan DR (1995), Weems JC (2015)	7
VHL	0	ELOB	1	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Ohh M (1999), Min JH (2002), Hacker KE (2008), Menon S (2008), Kamura T (2002), Kamura T (2002), Kuznetsova AV (2003), Cockman ME (2000), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Kinoshita K (2007), Lai Y (2012), Mahrour N (2008), Mahrour N (2008), Grosfeld A (2007), Foxler DE (2012), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017)	43
CDC14B	1	ELOA	3	bioid	St-Denis N (2016)	1
CTR9	10	5430	0	affinity chromatography technology	Hein MY (2015)	1
ELOA	3	NINL	1	two hybrid	Rual JF (2005)	1
ELOA	3	POLR2C	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
ELOA	3	ARHGAP26	3	affinity chromatography technology	Boldt K (2016)	1
REXO1	6	ELOA	3	affinity chromatography technology, pull down	Tamura K (2003), Tamura K (2003)	2
MED26	2	POLR2B	3	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
POLR2H	0	POLR2I	0	biochemical	Wan C (2015)	1
NINL	1	SPERT	0	two hybrid	Rual JF (2005)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
ELOA	3	POLR2I	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CUL5	1	POLR2C	0	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	POLR2B	3	affinity chromatography technology	Emdal KB (2015)	1
PSMB9	0	POLR2C	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
ELOA	3	POLR2E	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
LEO1	3	ELOA	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
ELOA	3	HOMEZ	2	two hybrid	Rolland T (2014)	1
POLR2C	0	POLR2L	1	pull down, pull down, biochemical	Acker J (1997), Acker J (1997), Wan C (2015)	3
NEDD8	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
BRCA1	7	POLR2I	0	affinity chromatography technology	Woods NT (2012)	1
ELOA	3	GMCL1	0	two hybrid	Rolland T (2014)	1
5430	0	POLR2C	0	pull down, pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Knuesel MT (2009), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	6
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
ARHGAP26	3	CTR9	10	affinity chromatography technology	Boldt K (2016)	1
NRXN1	14	ARHGAP26	3	affinity chromatography technology	Boldt K (2016)	1
POLR2C	0	POLR2G	0	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Acker J (1997), Acker J (1997), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
ELOA	3	JAKMIP2	3	two hybrid	Rolland T (2014)	1
VHL	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Norman JA (2006)	2
BRCA1	7	POLR2J	0	affinity chromatography technology	Woods NT (2012)	1
MED26	2	POLR2K	0	affinity chromatography technology	Takahashi H (2011)	1
NEDD8	0	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Russell RC (2011), Russell RC (2011)	2
CEP70	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
VHL	0	ELOA	3	affinity chromatography technology	Kamura T (2002)	1
NTRK1	1	YWHAZ	1	affinity chromatography technology	Emdal KB (2015)	1
CDC14B	1	PES1	3	bioid	St-Denis N (2016)	1
CEP57L1	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
ELOA	3	POLR2G	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
MED26	2	5430	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Sato S (2004), Takahashi H (2011), Takahashi H (2011)	4
5430	0	POLR2H	0	pull down, pull down, pull down, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Knuesel MT (2009), Wu W (2007), Wan C (2015)	5
CUL5	1	POLR2B	3	affinity chromatography technology	Bennett EJ (2010)	1
5430	0	POLR2E	0	pull down, pull down, pull down, biochemical, biochemical, affinity chromatography technology	Acker J (1997), Acker J (1997), Knuesel MT (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
POLR2B	3	POLR2C	0	pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	5
ECT2	2	ELOA	3	affinity chromatography technology	Woods NT (2012)	1
5430	0	POLR2F	1	pull down, pull down, biochemical, affinity chromatography technology	Acker J (1997), Knuesel MT (2009), Wan C (2015), Hein MY (2015)	4
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
ELOA	3	5430	0	imaging technique, imaging technique, enzymatic study	Zhang H (2006), Zhang H (2006), Yasukawa T (2008)	3
LEO1	3	CTR9	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rozenblatt-Rosen O (2005), Nordick K (2008), Nordick K (2008), Kim J (2010), Mak AB (2010), Mak AB (2010), Ouna BA (2012), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	12
MED26	2	POLR2D	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
POLR2C	0	POLR2E	0	pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	5
NTRK1	1	5430	0	affinity chromatography technology	Emdal KB (2015)	1
POLR2H	0	BARD1	4	affinity chromatography technology, enzymatic study, enzymatic study	Wu W (2007), Wu W (2007), Vittal V (2015)	3
PSMB9	0	POLR2F	1	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CTR9	10	POLR2B	3	affinity chromatography technology	Hein MY (2015)	1
BARD1	4	CDK12	3	affinity chromatography technology	Woods NT (2012)	1
POLR2D	0	POLR2E	0	pull down, biochemical, affinity chromatography technology	Schaller S (1999), Wan C (2015), Huttlin EL (2017)	3
POLR2K	0	POLR2J	0	pull down	Acker J (1997)	1
POLR2K	0	POLR2H	0	pull down, biochemical	Acker J (1997), Wan C (2015)	2
ELOA	3	SPERT	0	two hybrid	Rolland T (2014)	1
POLR2B	3	POLR2L	1	pull down, pull down, biochemical	Acker J (1997), Acker J (1997), Wan C (2015)	3
YWHAE	0	ELOA	3	imaging technique	Zippo A (2009)	1
ECT2	2	ELOC	0	two hybrid	Woods NT (2012)	1
POLR2C	0	POLR2F	1	pull down, pull down, biochemical, affinity chromatography technology	Acker J (1997), Acker J (1997), Wan C (2015), Hein MY (2015)	4
POLR2G	0	POLR2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CTR9	10	POLR2G	0	affinity chromatography technology	Hein MY (2015)	1
BARD1	4	CEP70	1	two hybrid	Rolland T (2014)	1
POLR2E	0	POLR2I	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ELOA	3	POLR2K	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
ASB9	0	ELOB	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Kwon S (2010), Kwon S (2010), Muniz JR (2013), Thomas JC (2013), Andresen CA (2014), Huttlin EL (2017)	6
POLR2J	0	POLR2D	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2004), Huttlin EL (2017)	3
POLR2J	0	POLR2G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
BARD1	4	POLR2E	0	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	POLR2G	0	affinity chromatography technology	Woods NT (2012)	1
5430	0	POLR2G	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Acker J (1997), Knuesel MT (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
ELOA	3	POLR2L	1	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CUL3	17	ELOC	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
POLR2B	3	POLR2I	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
POLR2G	0	POLR2H	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Acker J (1997), Acker J (1997), Hein MY (2015), Huttlin EL (2017)	4
MED26	2	POLR2C	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
ELOA	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
SOCS1	1	ELOA	3	affinity chromatography technology	Zhang JG (1999)	1
NRXN1	14	ELOA	3	affinity chromatography technology	Boldt K (2016)	1
POLR2B	3	POLR2H	0	pull down, pull down, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Jeronimo C (2007), Wan C (2015)	4
PES1	3	ELOA	3	affinity chromatography technology	Kellner M (2015)	1
POLR2L	1	POLR2H	0	pull down, biochemical	Acker J (1997), Wan C (2015)	2
BARD1	4	KRT40	0	two hybrid	Rolland T (2014)	1
BRCA1	7	POLR2D	0	affinity chromatography technology	Woods NT (2012)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
POLR2B	3	POLR2F	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
RAP1A	1	NTRK1	1	affinity chromatography technology	Wu C (2001)	1
ELOA	3	POLR2B	3	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
ASB9	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kwon S (2010), Debrincat MA (2007), Debrincat MA (2007), Muniz JR (2013), Thomas JC (2013), Andresen CA (2014), Huttlin EL (2015), Huttlin EL (2017)	8
PSMB9	0	POLR2E	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
PSMB9	0	POLR2G	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CUL5	1	POLR2D	0	affinity chromatography technology	Bennett EJ (2010)	1
ELOA	3	CUL3	17	affinity chromatography technology	Boldt K (2016)	1
BARD1	4	5430	0	affinity chromatography technology	Woods NT (2012)	1
CDK12	3	LEO1	3	genetic interference	Horlbeck MA (2018)	1
LZTS2	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
PSMB9	0	5430	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
CTR9	10	ELOC	0	affinity chromatography technology	Hein MY (2015)	1
BARD1	4	ELOA	3	affinity chromatography technology	Woods NT (2012)	1
KAT8	2	ELOA	3	imaging technique	Zippo A (2009)	1
RPGRIP1L	2	LZTS2	4	bioid	Gupta GD (2015)	1
POLR2C	0	POLR2J	0	pull down, pull down, two hybrid, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Corbi N (2002), Ayguen O (2008), Wan C (2015)	5
CUL3	17	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	POLR2C	0	affinity chromatography technology	Bennett EJ (2010)	1
LMNA	2	ELOA	3	two hybrid	Dittmer TA (2014)	1
BARD1	4	POLR2B	3	affinity chromatography technology	Woods NT (2012)	1
ELOB	1	SOCS1	1	affinity chromatography technology	Nie L (2011)	1
BRCA1	7	POLR2C	0	affinity chromatography technology	Woods NT (2012)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
POLR2K	0	POLR2B	3	pull down, biochemical	Acker J (1997), Wan C (2015)	2
POLR2J	0	POLR2B	3	affinity chromatography technology, affinity chromatography technology, biochemical	Jeronimo C (2007), Jeronimo C (2004), Wan C (2015)	3
5430	0	POLR2J	0	pull down, affinity chromatography technology, biochemical	Knuesel MT (2009), Jeronimo C (2004), Wan C (2015)	3
ELOA	3	CUL5	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Weems JC (2015), Weems JC (2015), Weems JC (2015)	3
MDFI	1	VHL	0	two hybrid	Rolland T (2014)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
BARD1	4	YWHAZ	1	affinity chromatography technology	Woods NT (2012)	1
CUL3	17	POLR2E	0	affinity chromatography technology	Bennett EJ (2010)	1
POLR2F	1	POLR2I	0	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
CUL5	1	VHL	0	pull down	Kamura T (2001)	1
ELOA	3	PLK4	1	two hybrid	Rolland T (2014)	1
LEO1	3	POLR2C	0	affinity chromatography technology	Hein MY (2015)	1
POLR2J	0	POLR2H	0	affinity chromatography technology	Jeronimo C (2007)	1
RPGRIP1L	2	ECT2	2	affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
YWHAE	0	POLR2D	0	biochemical	Wan C (2015)	1
VHL	0	POLR2G	0	two hybrid, pull down, affinity chromatography technology	Na X (2003), Na X (2003), Na X (2003)	3
MED26	2	POLR2L	1	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
ELOA	3	CHAF1A	1	biochemical	Wan C (2015)	1
ELOA	3	RAD54B	3	two hybrid	Venkatesan K (2009)	1
MED26	2	POLR2J	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
BARD1	4	FAM9B	0	two hybrid	Rolland T (2014)	1
ANTXR2	1	ELOA	3	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	5430	0	affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Mikhaylova O (2008), Kuznetsova AV (2003), Kuznetsova AV (2003), Sun W (2017)	4
POLR2D	0	POLR2C	0	pull down, biochemical, affinity chromatography technology, biochemical	Schaller S (1999), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	4
CTR9	10	ELOB	1	affinity chromatography technology	Hein MY (2015)	1
POLR2D	0	POLR2B	3	pull down, biochemical, biochemical, affinity chromatography technology	Schaller S (1999), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
YWHAZ	1	CHAF1A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Hoek M (2011), Hoek M (2011)	3
CUL3	17	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
RAD54B	3	GMCL1	0	two hybrid	Rolland T (2014)	1
CUL3	17	PES1	3	affinity chromatography technology	Bennett EJ (2010)	1
TRIM54	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
NTRK1	1	LMNA	2	affinity chromatography technology	Emdal KB (2015)	1
YWHAE	0	CHAF1A	1	two hybrid	Bandyopadhyay S (2010)	1
ELOA	3	POLR2H	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
POLR2E	0	POLR2H	0	pull down, pull down, biochemical, biochemical	Acker J (1997), Acker J (1997), Kristensen AR (2012), Wan C (2015)	4
MED26	2	POLR2G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
YWHAE	0	KAT8	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
CTR9	10	ELOA	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
POLR2D	0	5430	0	pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Schaller S (1999), Havugimana PC (2012), Wan C (2015), Zhao DY (2016), Huttlin EL (2017)	5
POLR2K	0	5430	0	pull down, biochemical	Acker J (1997), Wan C (2015)	2
5430	0	POLR2I	0	pull down, biochemical, biochemical	Knuesel MT (2009), Havugimana PC (2012), Wan C (2015)	3
MDFI	1	ELOA	3	two hybrid	Rolland T (2014)	1
ELOA	3	MED26	2	affinity chromatography technology	Takahashi H (2011)	1
POLR2D	0	POLR2I	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
5430	0	POLR2L	1	pull down, pull down, biochemical	Acker J (1997), Acker J (1997), Wan C (2015)	3
NTRK1	1	ELOA	3	affinity chromatography technology	Emdal KB (2015)	1
CTR9	10	POLR2D	0	affinity chromatography technology	Hein MY (2015)	1
ELOA	3	POLR2D	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
PSMB9	0	POLR2D	0	imaging technique, imaging technique	Zhang H (2006), Zhang H (2006)	2
ELOA	3	MID2	1	two hybrid	Rolland T (2014)	1
KRT40	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
MED26	2	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
POLR2F	1	POLR2J	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	LEO1	3	affinity chromatography technology	Emdal KB (2015)	1
MED26	2	POLR2H	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
POLR2K	0	POLR2F	1	pull down, biochemical	Acker J (1997), Wan C (2015)	2
BRCA1	7	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
MED26	2	POLR2I	0	affinity chromatography technology, affinity chromatography technology	Sato S (2004), Takahashi H (2011)	2
POLR2E	0	POLR2G	0	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Acker J (1997), Acker J (1997), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
POLR2L	1	POLR2I	0	biochemical	Wan C (2015)	1
LMNA	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
MID2	1	CEP57L1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ELOA	3	KRT40	0	two hybrid	Rolland T (2014)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
CUL3	17	GMCL1	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Rolland T (2014)	2
LEO1	3	POLR2K	0	genetic interference	Horlbeck MA (2018)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
BRCA1	7	POLR2E	0	affinity chromatography technology	Woods NT (2012)	1
NTRK1	1	PES1	3	affinity chromatography technology	Emdal KB (2015)	1
5430	0	POLR2B	3	pull down, biochemical, biochemical	Knuesel MT (2009), Havugimana PC (2012), Wan C (2015)	3
ELOA	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
ELOA	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
ELOA	3	FAM9B	0	two hybrid	Rolland T (2014)	1