Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
STAT4	6775	LISOFYLLINE	CHEMBL1411		TdgClinicalTrial
STAT4	6775	PROXYPHYLLINE	CHEMBL37390		NCI	10097133, 10415122, 10458767, 10861035, 11160329, 11418001, 11965047, 12123550, 15178894, 15356157, 16301617, 16324152, 9079804, 9144409, 9547334, 14660657

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
STAT4	rs7574865	T	adalimumab	efficacy	no		Allele T is not associated with response to adalimumab, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele G.	23007924	981417494
STAT4	rs7574865	GT + TT	ustekinumab	efficacy	yes	as measured by PASI75 at 4 months and adjusted for weight and FDR.	Genotypes GT + TT is associated with increased response to ustekinumab in people with Psoriasis as compared to genotype GG.	27977334	1448594887
STAT4	rs7574865	GG	rituximab	efficacy	no	No significant association was seen between genotype and whether a patient was a "responder" or a "non-responder". "Responders" had a post-rituximab disease activity score (DAS28) of lower than 5.1 and a DAS28 variation between baseline and post-treatment higher than 0.6. Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is not associated with response to rituximab in people with Arthritis, Rheumatoid as compared to genotypes GT + TT.	22129793	982047098
STAT4	rs7574865	T	etanercept	efficacy	yes	The degree of response was determined by EULAR score. A significant association between rs7574865 and response to etanercept was seen at two years after beginning treatment. No significant association was seen at six months after beginning treatment. No significant associations were seen at either time point when response was measured as number of patients in remission or with low disease activity.	Allele T is associated with decreased response to etanercept in people with Arthritis, Rheumatoid as compared to allele G.	28107378	1448995913
STAT4	rs7574865	T	adalimumab	efficacy	no	No significant associations were seen at either six months or two years after the beginning of treatment when response was measured as number of patients in remission or with low disease activity or by EULAR score.	Allele T is not associated with response to adalimumab in people with Arthritis, Rheumatoid as compared to allele G.	28107378	1448995921