PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
APC	5	ST14	2	two hybrid	Arroyo R (2015)	1
CHEK2	2	ST14	2	two hybrid	Arroyo R (2015)	1
NOTCH2	10	ST14	2	two hybrid	Arroyo R (2015)	1
ST14	2	SPINT1	1	affinity chromatography technology	Lin CY (1999)	1
PHB	0	ST14	2	two hybrid	Arroyo R (2015)	1
STK11	2	ST14	2	two hybrid	Arroyo R (2015)	1
CDKN2C	0	ST14	2	two hybrid	Arroyo R (2015)	1
CDKN2C	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ST14	2	PDGFC	0	enzymatic study	Hurst NJ (2012)	1
RAD51	3	ST14	2	two hybrid	Arroyo R (2015)	1
RGS16	0	ST14	2	two hybrid	Wang J (2011)	1
TGFB1	2	ST14	2	two hybrid	Arroyo R (2015)	1
AKT1	1	ST14	2	two hybrid	Arroyo R (2015)	1
CDKN2C	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CASP8	1	ST14	2	two hybrid	Arroyo R (2015)	1