PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2Z	0	SYVN1	2	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	RAPSN	2	two hybrid	Markson G (2009)	1
UBE2Z	0	TRIM65	1	two hybrid	Markson G (2009)	1
BAG3	4	RAPSN	2	affinity chromatography technology	Chen Y (2013)	1
MOV10	6	RNF144B	0	affinity chromatography technology	Castello A (2012)	1
UBE2Z	0	TRAIP	0	two hybrid	Markson G (2009)	1
NXF1	0	UBR1	3	affinity chromatography technology	Castello A (2012)	1
RNF166	0	RNF41	2	two hybrid	Woodsmith J (2012)	1
UBA6	4	UBE2Z	0	enzymatic study, enzymatic study, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study	Gavin JM (2012), Aichem A (2010), Aichem A (2010), Jin J (2007), Huang DT (2009), Huang DT (2009), Aichem A (2014)	7
UBE2Z	0	LNX2	2	two hybrid	Markson G (2009)	1
UBE2Z	0	RNF5	0	two hybrid	Markson G (2009)	1
NXF1	0	LNX2	2	affinity chromatography technology	Castello A (2012)	1
UBE2Z	0	RNF166	0	two hybrid	Markson G (2009)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
UBD	0	UBE2Z	0	two hybrid	Aichem A (2010)	1
REL	5	UBE2Z	0	two hybrid	Rolland T (2014)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
UBE2Z	0	WDR12	0	biochemical	Havugimana PC (2012)	1
UBE2Z	0	HLTF	7	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	MDM2	2	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	RNF130	0	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	TRIM46	3	two hybrid	Markson G (2009)	1
NXF1	0	UBE2Z	0	affinity chromatography technology	Castello A (2012)	1
UBA6	4	HMBOX1	2	two hybrid	Rolland T (2014)	1
BAG3	4	UBE2Z	0	affinity chromatography technology	Chen Y (2013)	1
NXF1	0	DZIP3	6	affinity chromatography technology	Castello A (2012)	1
UBA6	4	UBD	0	pull down, enzymatic study, two hybrid, affinity chromatography technology, imaging technique	Gavin JM (2012), Gavin JM (2012), Aichem A (2010), Theng SS (2014), Theng SS (2014)	5
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
DZIP3	6	UBR3	13	two hybrid	Woodsmith J (2012)	1
NXF1	0	RNF144B	0	affinity chromatography technology	Castello A (2012)	1
UBE2Z	0	HMBOX1	2	two hybrid	Rolland T (2014)	1
PPP1CA	3	UBE2Z	0	two hybrid	Esteves SL (2012)	1
UBE2Z	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
UBE2Z	0	RNF144B	0	two hybrid	van Wijk SJ (2009)	1
NXF1	0	BAG3	4	affinity chromatography technology	Castello A (2012)	1
UBE2Z	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	TRIM27	2	two hybrid	Markson G (2009)	1
PPP1CA	3	XPO1	8	biochemical	Kristensen AR (2012)	1
UBR2	8	UBE2Z	0	affinity chromatography technology	Lee PC (2011)	1
UBE2Z	0	UBR3	13	affinity chromatography technology	Lee PC (2011)	1
RNF41	2	PRKN	1	enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Yu F (2008), Zhong L (2005), Zhong L (2005), Zhong L (2005), Zhong L (2005)	5
RNF166	0	HLTF	7	affinity chromatography technology	Huttlin EL (2015)	1
UBR1	3	XPO1	8	biochemical	Havugimana PC (2012)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
UBE2Z	0	DZIP3	6	two hybrid	Markson G (2009)	1
WDR12	0	XPO1	8	biochemical	Havugimana PC (2012)	1
XPO1	8	REL	5	affinity chromatography technology	Kirli K (2015)	1
MOV10	6	PLEKHF2	1	affinity chromatography technology	Castello A (2012)	1
PRKN	1	UBE2Z	0	pull down	Kazlauskaite A (2014)	1
PRKN	1	REL	5	two hybrid	Corominas R (2014)	1
BAG3	4	UBA1	1	affinity chromatography technology	Chen Y (2013)	1
UBE2Z	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
LPL	3	UBE2Z	0	two hybrid	Stelzl U (2005)	1
MOV10	6	UBE2Z	0	affinity chromatography technology	Castello A (2012)	1
UBE2Z	0	UBR1	3	affinity chromatography technology	Lee PC (2011)	1
UBE2Z	0	RNF139	4	two hybrid	van Wijk SJ (2009)	1
UBE2Z	0	XPO1	8	biochemical	Havugimana PC (2012)	1
UBE2Z	0	AK8	1	two hybrid	Rolland T (2014)	1
UBE2Z	0	UBA1	1	enzymatic study, enzymatic study	Bialas J (2015), Huguenin-Dezot N (2016)	2
UBE2Z	0	RNF103	1	two hybrid	van Wijk SJ (2009)	1
UBA1	1	UBD	0	affinity chromatography technology	Rani N (2012)	1
MOV10	6	RNF150	2	affinity chromatography technology	Castello A (2012)	1