Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SLC1A3 6507 MESALAMINE CHEMBL704 GuideToPharmacologyInteractions
SLC1A3 6507 L-GLUTAMATE CHEMBL575060 DrugBank 16855093, 17088867, 16959378

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SLC1A3 rs1529461 AA + AG antipsychotics efficacy yes Only in patients who were in the "low severity group" based on baseline severity score, using clinical global impressions (CGI) score. Within a cohort of 1) all patients, 2) patients receiving atypical monotherapy and 3) patients receiving risperidone. Response assessed using CGI scale, patients were either complete responders (CR) or incomplete responders (IR) based on this scale. Those with the AA or AG genotype were more prevalent in the IR group in all three cohorts. Note that this association did not withstand correction for multiple testing. Genotypes AA + AG is associated with decreased response to antipsychotics in people with Schizophrenia as compared to genotype GG. 25209194 1446895550