PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
PARK7	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Opsahl JA (2010), Opsahl JA (2010), Opsahl JA (2010)	3
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
EFCAB6	3	HDAC1	4	affinity chromatography technology	Niki T (2003)	1
PARK7	0	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Tillman JE (2007), Tillman JE (2007), Tillman JE (2007)	3
PARK7	0	EFCAB6	3	affinity chromatography technology, pull down, two hybrid	Niki T (2003), Niki T (2003), Niki T (2003)	3
AR	3	SIN3A	13	affinity chromatography technology	Zhu P (2006)	1
EFCAB6	3	SIN3A	13	affinity chromatography technology	Niki T (2003)	1
AR	3	EFCAB6	3	affinity chromatography technology, pull down, affinity chromatography technology	Niki T (2003), Niki T (2003), Niki T (2003)	3