PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
EED	1	BMI1	0	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
YAF2	1	23429	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
CBX8	3	H1FX	0	affinity chromatography technology	Hein MY (2015)	1
USP7	14	HIST2H2AC	1	affinity chromatography technology, enzymatic study	Lecona E (2015), Yu M (2016)	2
UBR5	13	UBE2D3	1	pull down	Honda Y (2002)	1
UBR5	13	RNF2	1	imaging technique	Sanchez A (2016)	1
CBX7	1	NUFIP2	1	affinity chromatography technology	Hauri S (2016)	1
HDAC2	1	HIST2H2AC	1	enzymatic study	Gyoery I (2003)	1
EED	1	CBX8	3	affinity chromatography technology	Cao Q (2014)	1
TP53	0	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Al Rashid ST (2005), Al Rashid ST (2005)	2
TP53	0	CSNK2B	5	protein complementation assay	Srivastav RK (2011)	1
BTRC	1	UBE2D3	1	pull down	Chong RA (2014)	1
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
ELAVL1	0	PTEN	24	affinity chromatography technology	Abdelmohsen K (2009)	1
BMI1	0	TP53	0	affinity chromatography technology, affinity chromatography technology	Calao M (2012), Yin J (2013)	2
CBX7	1	PHC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Vandamme J (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
CBX4	1	CBX8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hein MY (2015), Hein MY (2015)	3
HIST2H2AA3	0	BMI1	0	affinity chromatography technology, enzymatic study	Richly H (2010), Bentley ML (2011)	2
RING1	2	PHC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Satijn DP (1997), Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
ELAVL1	0	PHC1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CBX2	0	CBX4	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Vandamme J (2011)	2
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
BMI1	0	HNF4A	2	affinity chromatography technology, affinity chromatography technology	Englert NA (2015), Englert NA (2015)	2
PHC3	1	RING1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hauri S (2016), Hauri S (2016)	3
RING1	2	PHC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang H (2004), Gao Z (2012), Hauri S (2016), Hauri S (2016)	4
HIST2H2AA3	0	RNF2	1	affinity chromatography technology, enzymatic study, enzymatic study	Richly H (2010), Bentley ML (2011), Cao Q (2014)	3
RNF2	1	XRCC5	5	affinity chromatography technology	Cao Q (2014)	1
23429	0	RNF2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	11
H2AFX	1	CBX5	3	affinity chromatography technology	Dittmann K (2011)	1
USP11	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Maertens GN (2010), Maertens GN (2010), Ma H (2012), Hein MY (2015)	7
RING1	2	23429	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Garcia E (1999), Garcia E (1999), Garcia E (1999), Garcia E (1999), Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	13
PHC3	1	CBX2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Hauri S (2016)	3
CBX2	0	RING1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Garcia E (1999), Gao Z (2012), Gao Z (2012), Hauri S (2016)	4
BMI1	0	ATRX	7	affinity chromatography technology, biochemical	Abdouh M (2016), Abdouh M (2016)	2
EED	1	PHC3	1	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	BMI1	0	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down	Satijn DP (1999), Gao Z (2012), Alchanati I (2009), Taherbhoy AM (2015), Gray F (2016)	5
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
PTEN	24	UBAP2L	4	genetic interference	Vizeacoumar FJ (2013)	1
CBX5	3	ATRX	7	imaging technique, unspecified method, affinity chromatography technology, affinity chromatography technology	Wong LH (2010), Lechner MS (2005), Berube NG (2000), Berube NG (2000)	4
RNF2	1	YAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
BMI1	0	H1FX	0	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Abdouh M (2016)	2
RING1	2	CBX4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Satijn DP (1999), Satijn DP (1997), Satijn DP (1997), Satijn DP (1997), Satijn DP (1999), Gao Z (2012), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
CBX7	1	BMI1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Maertens GN (2009), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
PHC3	1	NUFIP2	1	affinity chromatography technology	Hauri S (2016)	1
PHC1	1	CBX8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
CSNK2B	5	PHC2	3	two hybrid	Wang J (2011)	1
PHC2	3	HDAC2	1	affinity chromatography technology	Gao Z (2012)	1
RING1	2	TP53	0	affinity chromatography technology	Calao M (2012)	1
USP11	3	H2AFX	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Yu M (2016), Yu M (2016), Yu M (2016), Yu M (2016)	4
ELAVL1	0	23429	0	affinity chromatography technology	Abdelmohsen K (2009)	1
23429	0	CSNK2B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
YAF2	1	RING1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Rolland T (2014), Yu H (2011), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
RNF2	1	HIST2H2AC	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Wang H (2004), Zaaroor-Regev D (2010), Bentley ML (2011), Li Z (2006), Gearhart MD (2006), Gao Z (2014), Bhatnagar S (2014), Yang XX (2016)	8
UBR5	13	RING1	2	imaging technique	Sanchez A (2016)	1
ATRX	7	TP53	0	affinity chromatography technology, unspecified method	Leung JW (2013), Li Z (2017)	2
BMI1	0	23429	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
EED	1	CBX7	1	affinity chromatography technology	Cao Q (2014)	1
USP7	14	CBX8	3	affinity chromatography technology, affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010)	3
CBX7	1	RING1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gil J (2004), Maertens GN (2009), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Hauri S (2016), Hauri S (2016)	8
ELAVL1	0	DEK	1	affinity chromatography technology	Abdelmohsen K (2009)	1
BMI1	0	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010), de Bie P (2010), Lecona E (2015), Lecona E (2015)	6
ATRX	7	H2AFX	1	imaging technique	Choi EH (2017)	1
EED	1	PHC2	3	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	CBX6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
PHC3	1	CBX4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
RNF2	1	CBX4	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
USP7	14	RNF2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), Gao Z (2012), Cao Q (2014), Lecona E (2015), Lecona E (2015), Hein MY (2015)	12
CSNK2B	5	BTRC	1	affinity chromatography technology	Tsuchiya Y (2010)	1
PHC2	3	CBX6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Hauri S (2016), Hauri S (2016)	5
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
RNF2	1	SCMH1	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
CBX7	1	CSNK2B	5	affinity chromatography technology, affinity chromatography technology	Vandamme J (2011), Huttlin EL (2015)	2
RING1	2	CSNK2B	5	affinity chromatography technology	Hauri S (2016)	1
CBX7	1	PHC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	4
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
EED	1	H1FX	0	affinity chromatography technology	Cao Q (2014)	1
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
RING1	2	CBX8	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bardos JI (2000), Bardos JI (2000), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Rolland T (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	9
H2AFX	1	BMI1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ginjala V (2011), Pan MR (2011), Pan MR (2011), Pan MR (2011)	4
23429	0	MLLT1	1	affinity chromatography technology	Huttlin EL (2017)	1
BMI1	0	ZBTB16	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical	Barna M (2002), Barna M (2002), Barna M (2002), Barna M (2002), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009)	9
EED	1	CBX4	1	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	CBX6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Cao Q (2014), Hauri S (2016), Hauri S (2016)	8
RNF2	1	CBX8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Hein MY (2015), Hauri S (2016), Hauri S (2016)	10
PHC2	3	CBX2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Hauri S (2016)	4
USP11	3	CBX8	3	affinity chromatography technology, affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010)	3
BMI1	0	USP11	3	affinity chromatography technology, affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010)	3
CBX6	1	CBX4	1	affinity chromatography technology	Gao Z (2012)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
23429	0	TP53	0	affinity chromatography technology	Chen D (2009)	1
23429	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017)	3
BMI1	0	CBX2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Gao Z (2012), Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hauri S (2016)	7
BMI1	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Facchino S (2010), Cao Q (2014)	2
EED	1	HNF4A	2	affinity chromatography technology, affinity chromatography technology	Englert NA (2015), Englert NA (2015)	2
ZBTB16	4	TP53	0	affinity chromatography technology, affinity chromatography technology	Choi WI (2014), Choi WI (2014)	2
CBX4	1	SCMH1	1	affinity chromatography technology	Gao Z (2012)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
H2AFX	1	CBX2	0	imaging technique	Ginjala V (2011)	1
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RRM1	3	BMI1	0	affinity chromatography technology, enzymatic study	Zhang Y (2014), Zhang Y (2014)	2
H2AFX	1	RNF2	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Pan MR (2011), Pan MR (2011), Pan MR (2011), Pan MR (2011), Yang XX (2016)	5
UBR5	13	BMI1	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Sanchez A (2016), Sanchez A (2016), Sanchez A (2016)	3
ELAVL1	0	NUFIP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
USP11	3	RNF2	1	affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010)	2
UBE2D3	1	RING1	2	two hybrid	Markson G (2009)	1
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
PTEN	24	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wu Y (2013), Zhang J (2013), Zhang J (2013), Yuan L (2015)	4
BMI1	0	CBX8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Maertens GN (2009), Maertens GN (2010), Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	11
CBX4	1	CSNK2B	5	affinity chromatography technology, pull down	Vandamme J (2011), Vandamme J (2011)	2
YAF2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hauri S (2016)	2
YAF2	1	USP7	14	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017)	2
EED	1	DEK	1	affinity chromatography technology	Cao Q (2014)	1
EED	1	XRCC5	5	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	DEK	1	affinity chromatography technology, affinity chromatography technology	Abdouh M (2016), Abdouh M (2016)	2
PHC1	1	BMI1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Satijn DP (1997), Satijn DP (1997), Gunster MJ (1997), Gunster MJ (1997), Gunster MJ (1997), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Voncken JW (2005), Junco SE (2013), Sanchez A (2016), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	14
BMI1	0	RING1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Satijn DP (1997), Satijn DP (1997), Satijn DP (1999), Satijn DP (1999), Cao R (2005), Cao R (2005), Maertens GN (2009), Wei J (2006), Wang H (2004), Gao Z (2012), Gao Z (2012), Boukarabila H (2009), Abdel-Wahab O (2012), Woodsmith J (2012), Rolland T (2014), Cao Q (2014), Hauri S (2016), Hauri S (2016)	18
H2AFX	1	ELAVL1	0	affinity chromatography technology	Yang X (2010)	1
HIST2H2AC	1	DEK	1	affinity chromatography technology	Ko SI (2006)	1
RNF2	1	PHC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	6
PHC2	3	SCMH1	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Gao Z (2012)	2
MLLT1	1	CBX8	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Garcia-Cuellar MP (2001), Garcia-Cuellar MP (2001), Park G (2010), Zeisig DT (2005)	4
EED	1	HDAC2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Cao Q (2014)	6
XRCC5	5	ATM	9	pull down	Falck J (2005)	1
BMI1	0	HIST2H2AC	1	enzymatic study, enzymatic study	Li Z (2006), Bentley ML (2011)	2
MLLT1	1	HIST2H2AC	1	affinity chromatography technology	Ui A (2015)	1
PHC1	1	SCMH1	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017)	2
UBR5	13	UBAP2L	4	affinity chromatography technology	Sanchez A (2016)	1
PTEN	24	BMI1	0	affinity chromatography technology, affinity chromatography technology	Fan C (2009), Fan C (2009)	2
PHC1	1	PHC2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Gunster MJ (1997), Gunster MJ (1997), Gunster MJ (1997), Gao Z (2012), Gao Z (2012), Voncken JW (2005), Huttlin EL (2017)	8
RRM1	3	RNF2	1	affinity chromatography technology, enzymatic study	Zhang Y (2014), Zhang Y (2014)	2
BTRC	1	BMI1	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2011), Sahasrabuddhe AA (2011)	2
USP11	3	XRCC5	5	affinity chromatography technology	Zhou Z (2017)	1
BMI1	0	HDAC2	1	affinity chromatography technology, genetic interference	Abdouh M (2016), Wong AS (2016)	2
PHC2	3	CBX4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
BMI1	0	AGXT	0	pull down, biochemical	Boukarabila H (2009), Boukarabila H (2009)	2
PHC3	1	SCMH1	1	affinity chromatography technology	Gao Z (2012)	1
UBE2D3	1	RNF2	1	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Markson G (2009), Bentley ML (2011), Li Z (2006), Pan MR (2011), Zhang Y (2014), Xia P (2014), Gearhart MD (2006), McGinty RK (2014), Cao Q (2014), Gao Z (2014)	10
BMI1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, biochemical	Abdouh M (2016), Abdouh M (2016), Abdouh M (2016)	3
ZBTB16	4	HDAC2	1	pull down	Chauchereau A (2004)	1
YAF2	1	MLLT1	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	BMI1	0	pull down, affinity chromatography technology	Vandamme J (2011), Cao Q (2014)	2
PHC2	3	PHC3	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012)	2
PHC1	1	CBX2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Huttlin EL (2017), Hauri S (2016)	4
CBX6	1	NUFIP2	1	affinity chromatography technology	Hauri S (2016)	1
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
RNF2	1	CBX2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Hauri S (2016)	6
PHC2	3	CBX8	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Vandamme J (2011), Rolland T (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	6
ELAVL1	0	UBAP2L	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
USP7	14	RING1	2	affinity chromatography technology, pull down, affinity chromatography technology	Maertens GN (2010), de Bie P (2010), Hein MY (2015)	3
MAPKAPK3	0	PHC2	3	two hybrid, affinity chromatography technology	Voncken JW (2005), Voncken JW (2005)	2
BMI1	0	YAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Gao Z (2012), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
MLLT1	1	BMI1	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, pull down	Ui A (2015), Ui A (2015), Ui A (2015), Ui A (2015), Ui A (2015)	5
RNF2	1	PCBP2-OT1	0	affinity chromatography technology	Bo C (2016)	1
PHC3	1	CBX8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hein MY (2015), Hauri S (2016), Hauri S (2016)	4
RNF2	1	H1FX	0	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	UBAP2L	4	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Sanchez A (2016)	2
PHC1	1	CBX4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Satijn DP (1997), Satijn DP (1997), Gao Z (2012), Gao Z (2012), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
EED	1	23429	0	affinity chromatography technology	Cao Q (2014)	1
BMI1	0	PHC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hauri S (2016), Hauri S (2016)	6
MAPKAPK3	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Voncken JW (2005), Voncken JW (2005)	2
BMI1	0	PHC2	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Gunster MJ (1997), Gunster MJ (1997), Gunster MJ (1997), Wei J (2006), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Rolland T (2014), Cao Q (2014), Gray F (2016), Gray F (2016), Hauri S (2016), Hauri S (2016)	13
23429	0	CBX2	0	affinity chromatography technology, pull down	Garcia E (1999), Garcia E (1999)	2
ATM	9	H2AFX	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsai WB (2008), Tsai WB (2008), Dittmann K (2011), Pan MR (2011), Kim K (2012), Rezaeian AH (2017)	6
ATM	9	BMI1	0	affinity chromatography technology, affinity chromatography technology	Facchino S (2010), Pan MR (2011)	2
PHC1	1	CBX6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
YAF2	1	CSNK2B	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
CBX8	3	CSNK2B	5	affinity chromatography technology	Vandamme J (2011)	1
RNF2	1	PHC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
CBX7	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique	Federico A (2009), Federico A (2009), Federico A (2009), Federico A (2009), Forzati F (2012)	5
BMI1	0	CBX6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Hauri S (2016), Hauri S (2016)	7
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
RNF2	1	CSNK2B	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hauri S (2016)	4
EED	1	PHC1	1	affinity chromatography technology	Cao Q (2014)	1
BTRC	1	EED	1	affinity chromatography technology	Huttlin EL (2017)	1
CBX6	1	RING1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Hauri S (2016), Hauri S (2016)	6
BMI1	0	PCBP2-OT1	0	affinity chromatography technology, affinity chromatography technology	Bo C (2016), Bo C (2016)	2
BMI1	0	NUFIP2	1	affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Hauri S (2016)	2
EED	1	RING1	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014)	3
DEK	1	HDAC2	1	affinity chromatography technology	Hollenbach AD (2002)	1
RING1	2	PCBP2-OT1	0	affinity chromatography technology	Bo C (2016)	1
PHC1	1	PHC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Huttlin EL (2017)	3
H2AFX	1	HIST2H2AC	1	affinity chromatography technology	Lee HS (2010)	1
RNF2	1	MAPKAPK3	0	affinity chromatography technology	Voncken JW (2005)	1
USP7	14	EED	1	pull down, affinity chromatography technology	de Bie P (2010), Cao Q (2014)	2
ZBTB16	4	CBX5	3	affinity chromatography technology	Choi WI (2014)	1
BMI1	0	SCMH1	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
CBX5	3	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
PTEN	24	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Freeman DJ (2003), Freeman DJ (2003), Zhou M (2003), Zhou M (2003), Hong SW (2013), Li Y (2008)	6
MLLT1	1	RNF2	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Ui A (2015), Ui A (2015), Ui A (2015)	3
RNF2	1	PHC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Voncken JW (2005), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
BMI1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Bentley ML (2011), Li Z (2006), Zhang Y (2014), Taherbhoy AM (2015)	4
USP11	3	RING1	2	affinity chromatography technology	Maertens GN (2010)	1
PHC3	1	CBX6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Hauri S (2016), Hauri S (2016)	4
CBX7	1	RNF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2009), Vandamme J (2011), Vandamme J (2011), Vandamme J (2011), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
CBX4	1	BMI1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia ZB (2003), Satijn DP (1997), Satijn DP (1997), Aoto T (2008), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Sanchez A (2016), Hauri S (2016), Hauri S (2016)	13
PHC3	1	TP53	0	affinity chromatography technology	Hauri S (2016)	1
PHC1	1	HDAC2	1	affinity chromatography technology	Gao Z (2012)	1
PHC1	1	CBX7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	3
CBX2	0	CSNK2B	5	affinity chromatography technology	Vandamme J (2011)	1
MLLT1	1	H2AFX	1	affinity chromatography technology	Ui A (2015)	1
CBX2	0	NUFIP2	1	affinity chromatography technology	Hauri S (2016)	1
BMI1	0	IMMT	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Cao Q (2014)	2
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
ATRX	7	XRCC5	5	affinity chromatography technology	Leung JW (2013)	1