PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
ARHGAP9	2	MAPK14	0	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4
FHL2	0	ARHGAP9	2	two hybrid	Rolland T (2014)	1
FHL2	0	APP	1	pull down	Olah J (2011)	1
GRB2	2	ARHGAP9	2	two hybrid	Rolland T (2014)	1
SMAD9	0	ARHGAP9	2	two hybrid	Colland F (2004)	1
RBPMS	0	ARHGAP9	2	two hybrid	Rual JF (2005)	1
FASLG	0	ARHGAP9	2	unspecified method	Voss M (2009)	1
ARHGAP9	2	APP	1	pull down	Olah J (2011)	1
ARHGAP9	2	MAPK1	1	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4