PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM39	0	MOAP1	0	affinity chromatography technology, affinity chromatography technology, biochemical	Lee SS (2009), Lee SS (2009), Lee SS (2009)	3
MOAP1	0	ASPM	9	affinity chromatography technology	Huttlin EL (2017)	1
MOAP1	0	PNMA5	0	two hybrid	Rolland T (2014)	1
MAGEH1	0	MOAP1	0	two hybrid	Rual JF (2005)	1
MOAP1	0	DYRK2	1	affinity chromatography technology	Matsuura K (2016)	1
FZR1	1	DDB1	6	affinity chromatography technology, affinity chromatography technology	Lv XB (2010), Lv XB (2010)	2
MOAP1	0	BCL2L1	0	affinity chromatography technology	Tan KO (2001)	1
MOAP1	0	MYO5C	8	affinity chromatography technology	Huttlin EL (2017)	1
CCDC85B	0	MBIP	0	two hybrid	Rual JF (2005)	1
MOAP1	0	DCAF1	5	affinity chromatography technology	Matsuura K (2016)	1
RASSF6	2	MOAP1	0	affinity chromatography technology	Ikeda M (2009)	1
UBQLN4	2	PNMA1	0	two hybrid	Lim J (2006)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
MOAP1	0	PNMA1	0	affinity chromatography technology	Huttlin EL (2017)	1
MBIP	0	MOAP1	0	two hybrid	Rolland T (2014)	1
SIRT2	1	FZR1	1	enzymatic study	Kim HS (2011)	1
LATS1	3	MOAP1	0	two hybrid	Rolland T (2014)	1
MOAP1	0	BCL2	0	affinity chromatography technology	Tan KO (2001)	1
THOC1	1	MOAP1	0	two hybrid	Rolland T (2014)	1
MOAP1	0	DDB1	6	affinity chromatography technology	Matsuura K (2016)	1
MOAP1	0	PNMA8A	2	affinity chromatography technology	Huttlin EL (2017)	1
CAMK2D	3	MOAP1	0	two hybrid	Rolland T (2014)	1
PNMA1	0	PNMA8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Huttlin EL (2017)	3
MOAP1	0	BAX	3	affinity chromatography technology	Tan KO (2001)	1
DYRK2	1	UBR5	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
DYRK2	1	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
MOAP1	0	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
PNMA1	0	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
CACNA1A	21	MOAP1	0	two hybrid	Kahle JJ (2011)	1
CCDC85B	0	MOAP1	0	two hybrid	Rual JF (2005)	1
FZR1	1	MOAP1	0	affinity chromatography technology, pull down, enzymatic study	Huang NJ (2012), Huang NJ (2012), Huang NJ (2012)	3
MOAP1	0	MOAP1	0	affinity chromatography technology	Tan KO (2001)	1
UBQLN4	2	MOAP1	0	two hybrid	Lim J (2006)	1
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
MOAP1	0	UBR5	13	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Matsuura K (2016), Matsuura K (2016), Matsuura K (2016), Matsuura K (2016)	4
MOAP1	0	MYO9B	11	affinity chromatography technology	Huttlin EL (2017)	1
PNMA1	0	PNMA5	0	two hybrid	Rolland T (2014)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
DYRK2	1	DDB1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009), Maddika S (2009), Maddika S (2009), Hossain D (2017)	5
DCAF1	5	UBR5	13	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009)	2
BCL2L1	0	BAX	3	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Strobel T (1998), Zhang H (2002), Gillissen B (2003), Ren H (2011), Ren H (2011), Chinnaiyan AM (1997), Diaz JL (1997), Wang X (2009), Wang X (2009), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Tong J (2017), Huttlin EL (2017), Kim EM (2014)	17
MOAP1	0	DPPA2	0	two hybrid	Rual JF (2005)	1
MOAP1	0	PNMA2	0	affinity chromatography technology	Huttlin EL (2017)	1