PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF335	3	ASH2L	2	affinity chromatography technology	Garapaty S (2009)	1
CCR4	0	ZNF335	3	affinity chromatography technology	Garapaty S (2008)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
GATAD1	0	EMSY	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Varier RA (2016), Varier RA (2016), Varier RA (2016), Varier RA (2016)	6
CDK6	0	ZNF335	3	enzymatic study	Anders L (2011)	1
ZNF335	3	HCFC1	4	affinity chromatography technology	Garapaty S (2009)	1
NCOA6	6	ZNF335	3	pull down, two hybrid	Mahajan MA (2002), Mahajan MA (2002)	2
RPSA	2	ZNF335	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF335	3	RBBP5	3	affinity chromatography technology	Garapaty S (2009)	1
TFAP4	3	ZNF335	3	affinity chromatography technology	Ku WC (2009)	1
NCOA6	6	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee J (2008), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Tang Z (2013)	6
GATAD1	0	ZNF335	3	affinity chromatography technology	Varier RA (2016)	1
NCOA6	6	HCFC1	4	affinity chromatography technology	Tang Z (2013)	1
HSPB2	1	ZNF335	3	two hybrid	Grose JH (2015)	1
HCFC1	4	RBBP5	3	biochemical, affinity chromatography technology, biochemical	Yokoyama A (2004), Mak AB (2010), Havugimana PC (2012)	3
PHF12	6	EMSY	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Varier RA (2016), Varier RA (2016)	3
CCAR2	9	EMSY	3	affinity chromatography technology, affinity chromatography technology	Garapaty S (2009), Garapaty S (2009)	2
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
CDK4	2	ZNF335	3	enzymatic study	Anders L (2011)	1
CCAR2	9	RBBP5	3	affinity chromatography technology	Garapaty S (2009)	1
ZNF335	3	EMSY	3	affinity chromatography technology	Garapaty S (2009)	1
PHF12	6	ZNF335	3	affinity chromatography technology	Varier RA (2016)	1
ZNF335	3	CCAR2	9	affinity chromatography technology, two hybrid	Garapaty S (2009), Garapaty S (2009)	2
ASH2L	2	HCFC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Mak AB (2010), Tang Z (2013)	3
EMSY	3	RBBP5	3	affinity chromatography technology	Garapaty S (2009)	1
ASH2L	2	CCAR2	9	affinity chromatography technology, affinity chromatography technology	Garapaty S (2009), Garapaty S (2009)	2
ZNF335	3	WDR5	2	affinity chromatography technology	Garapaty S (2009)	1
GATAD1	0	PHF12	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hein MY (2015), Varier RA (2016), Varier RA (2016)	5
NCOA6	6	RBBP5	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goo YH (2003), Goo YH (2003), Goo YH (2003), Lee J (2008), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Tang Z (2013)	9
ASH2L	2	EMSY	3	affinity chromatography technology, affinity chromatography technology	Garapaty S (2009), Garapaty S (2009)	2
NCOA6	6	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee J (2008), Lee S (2006), Patel SR (2007), Tang Z (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	7
HCFC1	4	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yokoyama A (2004), Wysocka J (2003), Mak AB (2010), Havugimana PC (2012), Hauri S (2016)	5