PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BDNF	F11R	0	two hybrid	Wang J (2011)	1
NTF4	NTRK2	10	pull down, x-ray crystallography, imaging technique	Naylor RL (2002), Banfield MJ (2001), Chen TC (2014)	3
ELAVL1	BDNF	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BDNF	JUNB	0	two hybrid	Wang J (2011)	1
BDNF	NTRK2	10	pull down, pull down, pull down	Haniu M (1997), Naylor RL (2002), Aravamudan B (2012)	3
RHOU	BDNF	0	pull down	Dart AE (2015)	1
BDNF	NTF4	0	imaging technique	Chen TC (2014)	1
ELAVL1	F11R	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BDNF	APP	1	pull down	Olah J (2011)	1
BDNF	INPP5K	6	two hybrid	Wang J (2011)	1
BDNF	AGO3	4	two hybrid	Wang J (2011)	1