PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS5	0	NCOA1	6	two hybrid, pull down	Chauchereau A (2000), Chauchereau A (2000)	2
MYOD1	0	EP300	36	pull down, genetic interference, pull down, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Lau P (1999), Sartorelli V (1997), Sartorelli V (1997), Sartorelli V (1997), Magenta A (2003), Serra C (2007), Jin W (2011), Yuan W (1996), Yuan W (1996)	9
CSNK1E	0	RORA	4	two hybrid	Wallach T (2013)	1
PSMC5	4	RORA	4	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Lim J (2006), Albers M (2005), Albers M (2005)	4
RORA	4	PTBP1	2	affinity chromatography technology, affinity chromatography technology	Zhang A (2012), Zhang A (2012)	2
BHLHE41	0	MYOD1	0	pull down, pull down	Fujimoto K (2007), Fujimoto K (2007)	2
COPS5	0	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McCall CM (2008), Bennett EJ (2010), Olma MH (2009)	4
RUVBL1	2	RORA	4	affinity chromatography technology	Kim JH (2007)	1
CEBPB	2	EP300	36	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology	Mink S (1997), Mink S (1997), Mink S (1997), Mink S (1997), Mink S (1997), Deng WG (2004), Deng WG (2004), Deng WG (2003)	8
EP300	36	RORA	4	two hybrid, pull down	Lau P (1999), Lau P (1999)	2
RORA	4	NCOA1	6	two hybrid, two hybrid	Albers M (2005), Chan CM (2013)	2
NSD1	25	RORA	4	two hybrid	Chan CM (2013)	1
EZH2	4	MYOD1	0	affinity chromatography technology	Caretti G (2004)	1
RORA	4	PROX1	0	two hybrid	Albers M (2005)	1
RORA	4	PNRC2	0	two hybrid	Albers M (2005)	1
ZXDC	1	RORA	4	two hybrid	Albers M (2005)	1
COPS5	0	RUVBL1	2	affinity chromatography technology	Bennett EJ (2010)	1
EP300	36	DDB1	6	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
SMARCD3	0	RORA	4	pull down	Debril MB (2004)	1
RORA	4	NR0B1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RORA	4	LMO3	0	two hybrid	Lim J (2006)	1
RORA	4	DDB1	6	affinity chromatography technology, affinity chromatography technology	Lee JM (2012), Lee JM (2012)	2
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
MYOD1	0	RORA	4	pull down	Lau P (1999)	1
SMARCD3	0	MYOD1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Forcales SV (2012), Forcales SV (2012), Forcales SV (2012)	3
BHLHE41	0	RORA	4	two hybrid	Wallach T (2013)	1
COPS5	0	PTBP1	2	affinity chromatography technology	Bennett EJ (2010)	1
RORA	4	PNRC1	0	two hybrid	Albers M (2005)	1
PROX1	0	EP300	36	two hybrid, affinity chromatography technology	Chen Q (2002), Chen Q (2002)	2
GFAP	0	RORA	4	two hybrid	Rolland T (2014)	1
RORA	4	CEBPB	2	affinity chromatography technology	Ohoka N (2009)	1
CSNK1E	0	BHLHE41	0	two hybrid	Wallach T (2013)	1
RORA	4	EZH2	4	affinity chromatography technology, affinity chromatography technology	Lee JM (2012), Lee JM (2012)	2
NCOA1	6	EZH2	4	affinity chromatography technology, affinity chromatography technology	Shi B (2007), Shi B (2007)	2
RORA	4	COPS5	0	two hybrid	Albers M (2005)	1
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
RORA	4	DCAF1	5	affinity chromatography technology, affinity chromatography technology	Lee JM (2012), Lee JM (2012)	2
LRIF1	3	RORA	4	pull down	Li HJ (2007)	1
BHLHE41	0	CEBPB	2	affinity chromatography technology	Gulbagci NT (2009)	1