PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
ZNF350	1	RBBP8	1	affinity chromatography technology, affinity chromatography technology	Furuta S (2006), Furuta S (2006)	2
RNF11	0	ZNF350	1	two hybrid	Li H (2004)	1
ZNF350	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee YK (2007), Liao G (2005), Nishitsuji H (2012), Lin LF (2013)	4
ZNF350	1	EP300	36	affinity chromatography technology	Chen K (2015)	1
USP21	2	ZNF350	1	two hybrid	Heride C (2016)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	RBBP8	1	unspecified method, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rodriguez M (2003), Li S (1999), Li S (1999), Li S (1999), Wong AK (1998), Wong AK (1998), Li S (2000), Wu-Baer F (2001), Yu X (1998), Yu X (1998), Yu X (2000), Yu X (2000), Yu X (2000), Kim H (2007), Yu X (2006), Yu X (2006), Wu-Baer F (2010), Volcic M (2012), Wang B (2007), Wang B (2007), Furuta S (2006), Furuta S (2006), Drikos I (2009), Tischkowitz M (2008), Li S (2000), Wu-Baer F (2001), Chen L (2008), Sevcik J (2013), Johnson N (2013), Hill SJ (2014), Cruz-Garcia A (2014), Hu Y (2014), Parameswaran B (2015), Liu H (2015), Renaud E (2016)	35
VHL	0	TRIM28	1	pull down	Li Z (2003)	1
BRCA1	7	ZNF350	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng L (2000), Zheng L (2000), Zheng L (2000), Furuta S (2006), Furuta S (2006), Lin LF (2013)	6
VHL	0	ZNF350	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Chen K (2015), Chen K (2015), Chen K (2015), Chen K (2015)	4
NEK1	6	ZNF350	1	two hybrid	Surpili MJ (2003)	1
EP300	36	VHL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2011), Roe JS (2011), Ji W (2014), Chen K (2015)	5