PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	RAP1GAP	4	affinity chromatography technology	Kirli K (2015)	1
CSNK1G2	1	RAP1GAP	4	two hybrid	Vinayagam A (2011)	1
MAPK6	1	RAP1GAP	4	two hybrid	Vinayagam A (2011)	1
CNR1	0	GNAI3	0	affinity chromatography technology	Mukhopadhyay S (2001)	1
BRAF	12	RAP1GAP	4	pull down	Kao S (2001)	1
MAP1LC3B	1	RAP1GAP	4	two hybrid	Vinayagam A (2011)	1
RAP1GAP	4	CNR1	0	affinity chromatography technology	Jordan JD (2005)	1
EZH2	4	RAP1GAP	4	affinity chromatography technology	Cao Q (2014)	1
BTRC	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Sahasrabuddhe AA (2014), Huttlin EL (2017)	3
RAP1GAP	4	MEX3B	1	two hybrid	Stelzl U (2005)	1
FBXW11	2	RAP1GAP	4	affinity chromatography technology, affinity chromatography technology	Wang D (2014), Wang D (2014)	2
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
GNAI3	0	XPO1	8	biochemical	Kristensen AR (2012)	1
RAP1A	1	AFDN	10	two hybrid, pull down	Boettner B (2000), Boettner B (2000)	2
GNAI3	0	RAP1GAP	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAP1GAP	4	PLK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang D (2014), Wang D (2014), Wang D (2014)	3
DYNC1I1	1	RAP1GAP	4	two hybrid	Vinayagam A (2011)	1
BRAF	12	RAP1A	1	pull down, affinity chromatography technology	Okada T (1999), Wang Z (2006)	2
AFDN	10	RAP1GAP	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Su L (2003), Su L (2003), Su L (2003)	3
RAP1GAP	4	PFN2	0	two hybrid	Stelzl U (2005)	1
MAPK6	1	PLK1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
GNAZ	1	RAP1GAP	4	pull down	Meng J (1999)	1
BTRC	1	RAP1GAP	4	affinity chromatography technology, affinity chromatography technology	Wang D (2014), Wang D (2014)	2
RAP1GAP	4	RAP1A	1	enzymatic study	Castro AF (2003)	1
FBXW11	2	EZH2	4	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2