PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XRCC3	1	TRIM25	5	two hybrid, affinity chromatography technology	Arroyo R (2015), Choudhury NR (2017)	2
RAD51	3	RAD51D	1	imaging technique	Tarsounas M (2004)	1
DKKL1	1	RAD51B	1	affinity chromatography technology	Huttlin EL (2017)	1
XRCC3	1	APP	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
RAD51B	1	XRCC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miller KA (2002), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM25	5	RAD51C	1	affinity chromatography technology	Choudhury NR (2017)	1
SWSAP1	3	RAD51D	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
BRCA2	6	XRCC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wilson JB (2010), Wilson JB (2008), Hussain S (2006), Hein MY (2015)	4
DKKL1	1	CBWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
IL12RB1	2	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
RAD51C	1	APP	1	pull down	Olah J (2011)	1
RAD51C	1	RAD51B	1	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hussain S (2004), Sigurdsson S (2001), Miller KA (2002), Miller KA (2002), Miller KA (2002), Park JY (2014)	6
RAD51B	1	RAD51D	1	affinity chromatography technology	Miller KA (2002)	1
SWSAP1	3	XRCC3	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
TGOLN2	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
XRCC2	0	RAD51D	1	two hybrid, two hybrid, pull down, far western blotting, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Schild D (2000), Braybrooke JP (2003), Braybrooke JP (2003), Braybrooke JP (2003), Hussain S (2004), Liu N (2002), Schild D (2000), Rolland T (2014), Huttlin EL (2015), Yard BD (2016), Yard BD (2016), Huttlin EL (2017)	12
DKKL1	1	RAD51D	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	BSG	1	affinity chromatography technology	Choudhury NR (2017)	1
DKKL1	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2017)	1
RAD51C	1	XRCC3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Hussain S (2004), Miller KA (2002), Liu N (2002), Kurumizaka H (2001), Kurumizaka H (2001), Kurumizaka H (2001), Hein MY (2015), Park JY (2014)	8
BSG	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
HELQ	4	RAD51D	1	affinity chromatography technology	Adelman CA (2013)	1
RAD51C	1	RAD51D	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Miller KA (2002), Liu N (2002), Yard BD (2016), Yard BD (2016), Park JY (2014)	5
RAD51C	1	KLHL10	1	affinity chromatography technology	Huttlin EL (2017)	1
WNT4	0	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
BRCA2	6	RAD51	3	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sharan SK (1997), Lin HR (2003), Yu DS (2003), Yu DS (2003), Chen PL (1998), Chen PL (1998), Chen PL (1998), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sarkisian CJ (2001), Wong AK (1997), Wong AK (1997), Katagiri T (1998), Katagiri T (1998), Pellegrini L (2002), Tarsounas M (2004), Liu J (2001), Chen J (1998), Sharan SK (1997), Marmorstein LY (1998), Ohashi A (2005), Shivji MK (2006), Xia B (2006), Xia B (2006), Badie S (2010), Liu J (2010), Carreira A (2011), Chen CF (1999), Chen CF (1999), Chen CF (1999), Lee M (2011), Esashi F (2005), Esashi F (2005), Esashi F (2005), Thorslund T (2007), Thorslund T (2007), Esashi F (2007), Brough R (2012), Zhao W (2015), Chu WK (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Trego KS (2016), Luo K (2016)	46
HELQ	4	RAD51C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013), Adelman CA (2013)	3
IL12RB1	2	CBWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD51	3	XRCC2	0	imaging technique	Tarsounas M (2004)	1
THBS3	3	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
RAD51C	1	CCDC140	0	affinity chromatography technology	Huttlin EL (2017)	1
SWSAP1	3	RAD51	3	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
PALB2	3	BRCA2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hayakawa T (2010), Zhang F (2009), Sy SM (2009), Zhang F (2009), Xia B (2007), Xia B (2006), Xia B (2006), Xia B (2006), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Oliver AW (2009), Oliver AW (2009), Oliver AW (2009), Anantha RW (2013), Bleuyard JY (2012), Brough R (2012), Orthwein A (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Byrd PJ (2016), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Luijsterburg MS (2017), Foo TK (2017)	32
PALB2	3	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dray E (2010), Hayakawa T (2010), Zhang F (2009), Zhang F (2009), Xia B (2006), Anantha RW (2013), Bleuyard JY (2012), Trego KS (2016), Trego KS (2016), Trego KS (2016), Simhadri S (2014), Park JY (2014), Park JY (2014), Ma J (2012), Ma J (2012), Luijsterburg MS (2017), Foo TK (2017), Foo TK (2017)	18
HENMT1	2	RAD51C	1	affinity chromatography technology	Huttlin EL (2017)	1
HELQ	4	RAD51B	1	affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013)	2
RAD51C	1	PALB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Park JY (2014), Park JY (2014), Park JY (2014), Park JY (2014)	4
RAD51	3	XRCC3	1	imaging technique	Tarsounas M (2004)	1
ADAMTS4	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2017)	1
SWSAP1	3	RAD51C	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
WNT4	0	APP	1	pull down	Olah J (2011)	1
RAD51C	1	PTPN9	2	affinity chromatography technology	Huttlin EL (2017)	1
HELQ	4	XRCC2	0	affinity chromatography technology	Adelman CA (2013)	1
PALB2	3	XRCC3	1	pull down	Park JY (2014)	1
ADAMTS4	1	RAD51B	1	affinity chromatography technology	Huttlin EL (2017)	1
FAM174A	2	CBWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
RAD51	3	RAD51C	1	imaging technique, affinity chromatography technology, imaging technique, affinity chromatography technology	Tarsounas M (2004), Rodrigue A (2006), Rodrigue A (2006), Park JY (2014)	4
CBWD1	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2015)	1
RAD51C	1	BRCA2	6	affinity chromatography technology, affinity chromatography technology	Park JY (2014), Park JY (2014)	2
SPACA1	1	RAD51C	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM174A	2	RAD51C	1	affinity chromatography technology	Huttlin EL (2017)	1
SWSAP1	3	RAD51B	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
RAD51	3	RAD51B	1	imaging technique	Tarsounas M (2004)	1
RAD51C	1	XRCC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miller KA (2002), Liu N (2002), Huttlin EL (2015), Huttlin EL (2017), Park JY (2014)	5
EFNB3	1	RAD51C	1	affinity chromatography technology	Huttlin EL (2017)	1
DKKL1	1	XRCC2	0	affinity chromatography technology	Huttlin EL (2017)	1