PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HEY1	2	AKAP9	13	affinity chromatography technology	Lopez-Mateo I (2016)	1
SIRT7	1	CSNK2A1	15	affinity chromatography technology	Tsai YC (2012)	1
UGGT2	5	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
EGLN3	0	GBF1	4	affinity chromatography technology	Rodriguez J (2016)	1
RPGR	0	BIRC6	15	bioid	Gupta GD (2015)	1
ABRAXAS2	1	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
EGLN3	0	PSMC5	4	affinity chromatography technology	Rodriguez J (2016)	1
HERC2	9	UBE2D1	0	pull down	Bai B (2016)	1
PLK1	0	BIRC6	15	affinity chromatography technology	Hein MY (2015)	1
UBC	7	GBF1	4	pull down	Zhang X (2017)	1
CCDC22	1	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
BIRC6	15	ANAPC11	0	affinity chromatography technology	Kikuchi R (2014)	1
CSNK2A1	15	BIRC6	15	enzymatic study	Zhang M (2011)	1
HERC2	9	CCDC22	1	affinity chromatography technology	Galligan JT (2015)	1
GSDME	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
PRSS45	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
HEY1	2	BIRC6	15	affinity chromatography technology	Lopez-Mateo I (2016)	1
CLEC11A	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
EGLN3	0	CSNK2A1	15	affinity chromatography technology	Rodriguez J (2016)	1
HEY1	2	TP53	0	pull down	Lopez-Mateo I (2016)	1
MYH13	9	BIRC6	15	affinity chromatography technology	Hein MY (2015)	1
UBC	7	ABRAXAS2	1	pull down, pull down	Wang B (2009), Nathan JA (2013)	2
UBC	7	ANGPTL3	3	pull down	Nathan JA (2013)	1
SIRT7	1	HERC2	9	affinity chromatography technology	Tsai YC (2012)	1
BIRC6	15	UBE2D1	0	pull down	Hao Y (2004)	1
BIRC6	15	MCPH1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ge C (2015), Ge C (2015), Ge C (2015)	3
HERC2	9	BIRC6	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Galligan JT (2015), Huttlin EL (2017)	3
RASSF2	2	AKAP9	13	bioid	Couzens AL (2013)	1
KIF22	1	BIRC6	15	affinity chromatography technology	Hein MY (2015)	1
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
UBC	7	HERC2	9	affinity chromatography technology, pull down	Rendtlew Danielsen J (2012), Zhang X (2017)	2
USP8	7	BIRC6	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pohl C (2008), Ge C (2015), Ge C (2015), Ge C (2015)	4
CHIA	5	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAV2	6	BIRC6	15	two hybrid	Thalappilly S (2008)	1
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
CA11	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
TBC1D22A	3	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
BIRC6	15	CASP7	1	affinity chromatography technology, enzymatic study	Bartke T (2004), Qiu XB (2005)	2
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
GBF1	4	EPS15L1	1	biochemical	Kristensen AR (2012)	1
UBE2D1	0	UNK	3	biochemical	Havugimana PC (2012)	1
BIRC6	15	HTRA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Hao Y (2004), Sekine K (2005), Sekine K (2005), Bartke T (2004), Qiu XB (2005), Qiu XB (2005)	6
DCAF12	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
SIRT7	1	KIF23	0	affinity chromatography technology	Tsai YC (2012)	1
TEX35	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
BIRC6	15	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Kikuchi R (2014), Kikuchi R (2014)	2
MCPH1	4	CDC27	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Singh N (2012), Singh N (2012), Singh N (2012)	3
HERC2	9	AKAP9	13	affinity chromatography technology	Galligan JT (2015)	1
BIRC6	15	CDC27	2	affinity chromatography technology	Kikuchi R (2014)	1
SIRT7	1	TP53	0	affinity chromatography technology	Tsai YC (2012)	1
TP53	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014), Zhang J (2014), Huttlin EL (2015), Huttlin EL (2017)	5
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
CCNA2	1	CCNQ	0	affinity chromatography technology	Hein MY (2015)	1
RMND5A	0	HTRA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Lampert F (2018)	3
UNK	3	BIRC6	15	affinity chromatography technology	Murn J (2015)	1
EPS15L1	1	BIRC6	15	biochemical	Kristensen AR (2012)	1
CCNA2	1	CDC27	2	affinity chromatography technology	Mateo F (2009)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
RASSF2	2	BIRC6	15	bioid	Couzens AL (2013)	1
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
HEY1	2	CSNK2A1	15	affinity chromatography technology	Lopez-Mateo I (2016)	1
RNF41	2	BIRC6	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wu X (2004), Qiu XB (2004), Qiu XB (2004), Qiu XB (2004)	4
USP8	7	MCPH1	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Ge C (2015), Ge C (2015), Ge C (2015)	3
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
ANGPTL3	3	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
RMND5A	0	PSMC5	4	affinity chromatography technology	Lampert F (2018)	1
LLGL2	4	BIRC6	15	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	BIRC6	15	affinity chromatography technology	Rodriguez J (2016)	1
SIRT7	1	BIRC6	15	affinity chromatography technology	Tsai YC (2012)	1
PSMC5	4	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
HERC2	9	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Bai B (2016)	4
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
EGLN3	0	CDC27	2	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Tang W (2015), Tang W (2015)	2
CDC27	2	ANAPC11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Dube P (2005), Lu L (2013), Gmachl M (2000), Vodermaier HC (2003), Craney A (2016)	8
BIRC6	15	CASP9	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hao Y (2004), Bartke T (2004), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005)	5
WDR4	4	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
C3orf20	2	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	BIRC6	15	affinity chromatography technology	Matsumoto M (2005)	1
UNK	3	MGST3	0	affinity chromatography technology	Murn J (2015)	1
BIRC6	15	CASP3	0	affinity chromatography technology, pull down, enzymatic study	Bartke T (2004), Qiu XB (2005), Qiu XB (2005)	3
CASP8	1	BIRC6	15	enzymatic study	Qiu XB (2005)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
VEGFD	3	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MOS	1	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
644619	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF41	2	USP8	7	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe	Wu X (2004), Wu X (2004), Avvakumov GV (2006), Avvakumov GV (2006), Wijesuriya TM (2017), De Ceuninck L (2013), De Ceuninck L (2013), De Ceuninck L (2013)	8
EGLN3	0	RMND5A	0	affinity chromatography technology	Rodriguez J (2016)	1
KIF23	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Pohl C (2008), Pohl C (2008)	2
SIRT7	1	PSMC5	4	affinity chromatography technology	Tsai YC (2012)	1
BIRC6	15	BIRC6	15	affinity chromatography technology	Bartke T (2004)	1
ANAPC11	0	UBE2D1	0	pull down, pull down, pull down, pull down	Wu T (2010), Townsend K (2009), Summers MK (2009), Cao J (2015)	4
LLGL2	4	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
AGRP	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
FERMT2	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
ANAPC11	0	CCNA2	1	affinity chromatography technology	Kikuchi R (2014)	1
USP8	7	KIF23	0	affinity chromatography technology	Pohl C (2008)	1
GBF1	4	BIRC6	15	biochemical	Kristensen AR (2012)	1
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
CCNA2	1	TP53	0	pull down	Luciani MG (2000)	1
PLK1	0	EPS15L1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
RMND5A	0	BIRC6	15	affinity chromatography technology	Lampert F (2018)	1
ADAMTS4	1	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
MGST3	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	WDR4	4	biochemical	Havugimana PC (2012)	1
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
ABRAXAS2	1	PSMC5	4	affinity chromatography technology	Huttlin EL (2017)	1
RTBDN	0	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
SSH3	3	BIRC6	15	bioid	St-Denis N (2016)	1
BIRC6	15	DIABLO	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hao Y (2004), Hao Y (2004), Hao Y (2004), Sekine K (2005), Bartke T (2004), Bartke T (2004), Burke SP (2010), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005), Lamers F (2012), Kikuchi R (2014), Hao Y (2004), Huttlin EL (2017)	14
OSBPL2	3	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
AKAP9	13	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
CCNQ	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	EPS15L1	1	pull down	Zhang X (2017)	1