Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
PROC	5624	MENADIONE	CHEMBL590	activator	TEND, DrugBank	17215245, 17139284, 17016423
PROC	5624	WARFARIN	CHEMBL1464		FDA
PROC	5624	SODIUM TETRADECYL SULFATE	CHEMBL1200354	inhibitor	TdgClinicalTrial, TEND, DrugBank, TTD	11752352, 17016423, 1344580, 19442540

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PROC	rs2069919	G	warfarin	dosage	no		Allele G is not associated with dose of warfarin.	19794411	608431749
PROC	rs1799809	AA	phenprocoumon	"dosage","metabolism/PK"	yes	Daily dose of phenprocoumon is not significantly associated with this SNP. Daily dose is negatively correlated with age. This study published an algorithm for daily dose that includes height, although height was not significant in univariate analysis. This SNP is also not significantly associated with phenprocoumon concentration.	Genotype AA is not associated with increased dose of phenprocoumon as compared to genotypes AG + GG.	21110013	982046695
PROC	rs1799808	CC	phenprocoumon	"dosage","metabolism/PK"	yes	Patients with the CC genotype require significantly higher daily doses of phenprocoumon as compared to patients with the CT or TT genotype. While it seems that there may be a gene dose effect (CC>CT>TT), the paper did not specify whether or not this is the case. Daily dose is also negatively correlated with age. This study published an algorithm for daily dose that includes height, although height was not significant in univariate analysis. This SNP is not associated with differences in phenprocoumon concentration.	Genotype CC is associated with increased dose of phenprocoumon as compared to genotypes CT + TT.	21110013	982046699