PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK10	0	GTF3C1	11	two hybrid	Stelzl U (2005)	1
TP53	0	CCT2	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
MAPK10	0	ARRB2	5	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
RELA	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Zhong H (2002), Zhong H (2002), Zhong H (2002), Zhong H (2002), Ashburner BP (2001), Ashburner BP (2001), OShea JM (2010), OShea JM (2010), Liu Y (2006), Cao W (2006), Hu J (2004), Hu J (2004), Sun JM (2007), Deckmann K (2012)	15
ARRB1	2	MAPK9	3	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
CDKN2C	0	TP53	0	two hybrid	Stelzl U (2005)	1
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
MAPK10	0	EZR	8	affinity chromatography technology	Varjosalo M (2013)	1
TP53	0	DDX5	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
MAPK10	0	DUSP9	0	pull down	Camps M (1998)	1
CREBBP	29	ELK1	2	far western blotting	Janknecht R (1996)	1
MAPK10	0	ARRB1	2	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
ARRB2	5	DDX5	2	affinity chromatography technology	Xiao K (2007)	1
MAPK10	0	CCT7	2	affinity chromatography technology	Huttlin EL (2015)	1
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
MAPK10	0	CEP290	5	two hybrid	Bandyopadhyay S (2010)	1
FBXO7	1	MAPK9	3	enzymatic study	Teixeira FR (2016)	1
MAPK10	0	DDI1	1	affinity chromatography technology	Huttlin EL (2017)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
CCT2	1	CCT6B	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GCH1	0	MAP2K4	3	affinity chromatography technology	Chiarini A (2009)	1
MAPK9	3	HDAC9	7	affinity chromatography technology, pull down	Morrison BE (2006), Morrison BE (2006)	2
MAPK9	3	ELK1	2	enzymatic study, two hybrid, enzymatic study	Gupta S (1996), Yao K (2007), Cavigelli M (1995)	3
CEP290	5	LDHA	2	affinity chromatography technology	Gupta GD (2015)	1
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
MAPK10	0	HDAC9	7	affinity chromatography technology, pull down	Morrison BE (2006), Morrison BE (2006)	2
RELA	1	JUN	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
HDAC9	7	TP53	0	affinity chromatography technology	Yuan Z (2010)	1
LDHA	2	CCT6B	2	biochemical	Wan C (2015)	1
MAPK10	0	UNC119	4	two hybrid	Stelzl U (2005)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
FBXO7	1	DDX5	2	affinity chromatography technology	Teixeira FR (2016)	1
MAPK10	0	RDX	1	affinity chromatography technology	Varjosalo M (2013)	1
HDAC1	4	CDKN2A	1	pull down, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
TP53	0	CCT7	2	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
DUSP10	3	MAPK9	3	affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), St-Denis N (2016)	2
MAPK9	3	ARRB2	5	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
CDKN1B	1	MAPK10	0	pull down	Chang TS (2003)	1
MAPK9	3	WDR62	6	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Rual JF (2005), Wasserman T (2010), Wasserman T (2010), Rolland T (2014)	4
ATF2	1	CCT2	1	affinity chromatography technology	Lau E (2012)	1
HDAC1	4	CCT2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ATF2	1	APP	1	pull down	Olah J (2011)	1
HDAC1	4	CCT6B	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK8IP2	5	MAPK10	0	pull down	Negri S (2000)	1
EZR	8	RDX	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
ARRB1	2	KIF26A	15	affinity chromatography technology	Xiao K (2007)	1
ELK1	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ATF2	1	LDHA	2	affinity chromatography technology	Lau E (2012)	1
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
MAPK10	0	IMPDH2	3	affinity chromatography technology	Varjosalo M (2013)	1
MAPK10	0	WDR62	6	affinity chromatography technology	Varjosalo M (2013)	1
DUSP16	0	HAX1	1	affinity chromatography technology	Yadav L (2017)	1
CDKN2A	1	MAPK10	0	two hybrid, pull down	Choi BY (2005), Choi BY (2005)	2
MAPK9	3	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
TP53	0	MAPK9	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hu MC (1997), Lin Y (2002), Li Y (2012)	3
MAPK9	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, enzymatic study	Kallunki T (1996), Natoli G (1997), Chin AI (1999), Ho DT (2006), Yao K (2009), Gupta S (1996), Gupta S (1996), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Katagiri C (2006), Yao K (2007), Phelan DR (2001), Ho DT (2003), Camps M (1998)	16
DUSP1	1	MAPK9	3	affinity chromatography technology	Tanoue T (2001)	1
MAPK10	0	RELA	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
HAX1	1	MAPK10	0	two hybrid, affinity chromatography technology	Wang J (2011), Varjosalo M (2013)	2
HDAC9	7	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhou X (2000), Morrison BE (2006), Sparrow DB (1999), Sparrow DB (1999)	4
CCT2	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
DUSP16	0	MAPK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), St-Denis N (2016), Li X (2016)	3
DUSP16	0	MAPK10	0	affinity chromatography technology	Tanoue T (2001)	1
MAPK9	3	ATF2	1	enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study, enzymatic study, two hybrid	Ho DT (2006), Gupta S (1996), Gupta S (1996), Yao K (2007), Ho DT (2003), Sanna MG (2002), Rolland T (2014)	7
HDAC1	4	MAPK9	3	affinity chromatography technology	Morrison BE (2006)	1
ELK1	2	HDAC1	4	pull down	Yang SH (2001)	1
LDHA	2	MAPK10	0	two hybrid	Rolland T (2014)	1
MAPK10	0	CCT2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCL1	1	TP53	0	unspecified method, affinity chromatography technology	Lee MS (2014), Zhang X (2016)	2
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
MAPK10	0	DDX5	2	affinity chromatography technology	Varjosalo M (2013)	1
DDX5	2	CREBBP	29	affinity chromatography technology	Rossow KL (2003)	1
TP53	0	MAPK10	0	affinity chromatography technology	Hu MC (1997)	1
MAPK10	0	MSN	0	affinity chromatography technology	Varjosalo M (2013)	1
RELA	1	CDKN2A	1	affinity chromatography technology	Veena MS (2014)	1
MAPK10	0	KIF26A	15	two hybrid	Bandyopadhyay S (2010)	1
MAPK10	0	ATF2	1	enzymatic study, pull down, enzymatic study	Gupta S (1996), Gupta S (1996), Sanna MG (2002)	3
MAPK10	0	JUN	0	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, two hybrid, enzymatic study	Yao K (2009), Gupta S (1996), Gupta S (1996), Katagiri C (2006), Choi BY (2005), Wang J (2011), Camps M (1998)	7
SH3BP5	0	MAPK9	3	pull down	Wiltshire C (2002)	1
SH3BP5	0	APP	1	pull down	Olah J (2011)	1
GCH1	0	MAPK10	0	affinity chromatography technology, affinity chromatography technology	Chiarini A (2009), Chiarini A (2009)	2
SH3BP5	0	MAPK10	0	pull down	Wiltshire C (2002)	1
MAPK10	0	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
MAPK10	0	ELK1	2	enzymatic study	Gupta S (1996)	1
MAPK8IP3	9	MAPK9	3	pull down, pull down	Ito M (1999), Kelkar N (2000)	2
CDKN2C	0	UNC119	4	two hybrid	Stelzl U (2005)	1
HDAC1	4	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wilson BJ (2004), Wilson BJ (2004), Guo J (2010), Jacobs AM (2007), Mooney SM (2010), Mooney SM (2010)	6
CCT6B	2	CCT7	2	biochemical	Wan C (2015)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
MAPK10	0	MAPK10	0	enzymatic study, affinity chromatography technology	Choi HS (2009), Varjosalo M (2013)	2
MAPK10	0	MCL1	1	enzymatic study	Li QM (2007)	1
MAPK8IP3	9	MAPK10	0	two hybrid, two hybrid, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Ito M (1999), Ito M (1999), Ito M (1999), Ito M (1999), Kelkar N (2000), Matsuura H (2002), Matsuura H (2002)	7
MAPK10	0	PKMYT1	1	two hybrid, affinity chromatography technology, pull down, enzymatic study	Choi HS (2009), Choi HS (2009), Choi HS (2009), Choi HS (2009)	4
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
DUSP10	3	MAPK10	0	affinity chromatography technology	Tanoue T (2001)	1
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
DUSP1	1	MAPK10	0	affinity chromatography technology	Tanoue T (2001)	1
MAPK10	0	PLIN2	0	two hybrid	Wang J (2008)	1
MAPK10	0	TNIP1	1	two hybrid	Wang J (2011)	1
HDAC1	4	CCT7	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MAPK8IP3	9	MAP2K4	3	affinity chromatography technology, affinity chromatography technology	Ito M (1999), Matsuura H (2002)	2
MAP2K4	3	APP	1	pull down	Olah J (2011)	1
MAPK10	0	CCT6B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
MAPK8IP2	5	UNC119	4	two hybrid	Vinayagam A (2011)	1
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
MAP2K4	3	MAPK10	0	enzymatic study, pull down, unspecified method	Ryoo K (2004), Ho DT (2003), Ho DT (2003)	3
FBXO7	1	MAPK10	0	enzymatic study	Teixeira FR (2016)	1
MAPK10	0	APP	1	pull down	Olah J (2011)	1
JUN	0	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
JUN	0	HDAC9	7	pull down	Morrison BE (2006)	1
MAPK8IP2	5	DUSP16	0	affinity chromatography technology	Willoughby EA (2003)	1
HDAC1	4	MAPK10	0	affinity chromatography technology	Morrison BE (2006)	1
CCT7	2	APP	1	pull down	Olah J (2011)	1
MAPK8IP3	9	MAPK8IP2	5	pull down, pull down, affinity chromatography technology	Kelkar N (2000), Kelkar N (2000), Huttlin EL (2017)	3
MAPK10	0	CDKN2C	0	pull down	Choi BY (2005)	1
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8