PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GTF2IRD1	6	SP1	0	imaging technique	Carmona-Mora P (2015)	1
YAF2	1	23429	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF7IP	5	PML	7	imaging technique	Sasai N (2013)	1
MBD1	1	SP1	0	pull down	Schwarzenbach H (2014)	1
PML	7	SP1	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Vallian S (1998), Vallian S (1998), Chuang YS (2011), Li J (2014), Li J (2014)	5
GTF2E2	2	GTF2E1	1	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, biochemical, x-ray crystallography, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Watanabe T (2003), Maxon ME (1994), Okamoto T (1998), Yamamoto S (2001), Jeronimo C (2007), Havugimana PC (2012), Jawhari A (2006), Jawhari A (2006), Jawhari A (2006), Wan C (2015), Huttlin EL (2017)	11
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
VHL	0	ATF7IP	5	affinity chromatography technology	Huttlin EL (2017)	1
ATF7IP	5	ARL14EP	1	affinity chromatography technology	Huttlin EL (2017)	1
MBD1	1	SETDB1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Lyst MJ (2006), Sarraf SA (2004), Sarraf SA (2004), Sarraf SA (2004)	4
VHL	0	ARL14EP	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	RPL8	2	enzymatic study	Matafora V (2009)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
EWSR1	2	RPL8	2	affinity chromatography technology	Elzi DJ (2014)	1
SREBF2	5	ATF7IP	5	two hybrid	Bandyopadhyay S (2010)	1
TADA3	0	ATF7IP	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCAPH	2	ATF7IP	5	affinity chromatography technology	Hein MY (2015)	1
CREB1	1	SREBF2	5	two hybrid	Bandyopadhyay S (2010)	1
SMAD4	9	UBE2I	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Chang CC (2005), Lin X (2003), Colland F (2004), Wang J (2011), Wang J (2011)	6
SMAD4	9	ATF7IP	5	two hybrid, two hybrid	Colland F (2004), Wang J (2011)	2
MAPK3	4	ATF7IP	5	affinity chromatography technology	Hein MY (2015)	1
DISC1	6	ATF7IP	5	two hybrid	Morris JA (2003)	1
ATF7IP	5	RPL8	2	biochemical	Havugimana PC (2012)	1
PRR20E	0	ATF7IP	5	affinity chromatography technology	Huttlin EL (2017)	1
5430	0	EWSR1	2	affinity chromatography technology	Dutertre M (2010)	1
SREBF2	5	UBE2I	0	affinity chromatography technology, two hybrid	Hirano Y (2003), Bandyopadhyay S (2010)	2
SUMO2	0	ATF7IP	5	pull down	Ouyang J (2009)	1
ATF7IP	5	SETDB1	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ichimura T (2005), Ichimura T (2005), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
ATF7IP	5	ERCC3	3	affinity chromatography technology	Liu L (2009)	1
ERCC3	3	GTF2E2	2	pull down	Maxon ME (1994)	1
EWSR1	2	SMAD4	9	two hybrid	Rual JF (2005)	1
SUV39H1	0	ATF7IP	5	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	SP1	0	affinity chromatography technology, affinity chromatography technology, pull down	Yuen JS (2007), Mukhopadhyay D (1997), Mukhopadhyay D (1997)	3
GTF2E2	2	5430	0	affinity chromatography technology, biochemical	Watanabe T (2003), Wan C (2015)	2
ATF7IP	5	5430	0	affinity chromatography technology	Liu L (2009)	1
GTF2E1	1	ERCC3	3	pull down, pull down	Maxon ME (1994), Maxon ME (1994)	2
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SP1	0	SMAD4	9	affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Luciakova K (2008), Pardali K (2000), Pardali K (2000), Pardali K (2000), Chung CL (2011), Jungert K (2006)	6
SUV39H1	0	SETDB1	3	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	SETDB1	3	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
5430	0	ERCC3	3	affinity chromatography technology	Fousteri M (2006)	1
SETDB1	3	PML	7	affinity chromatography technology, affinity chromatography technology	Cho S (2011), Cho S (2011)	2
CREB1	1	ATF7IP	5	two hybrid	Bandyopadhyay S (2010)	1
SP1	0	ATF7IP	5	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down	Liu L (2009), Liu L (2009), Chang LK (2005), Chang LK (2005), Ichimura T (2005), Ichimura T (2005)	6
EWSR1	2	ATF7IP	5	bioid	Elzi DJ (2014)	1
EWSR1	2	GTF2E1	1	bioid	Elzi DJ (2014)	1
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
UBE2I	0	ATF7IP	5	two hybrid	Bandyopadhyay S (2010)	1
ATF7IP	5	GTF2E1	1	affinity chromatography technology, biochemical	Liu L (2009), Wan C (2015)	2
PRR20E	0	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
ATF7IP	5	ERCC2	4	affinity chromatography technology	Liu L (2009)	1
UBE2I	0	SETDB1	3	two hybrid	Bandyopadhyay S (2010)	1
EWSR1	2	SUMO2	0	bioid	Elzi DJ (2014)	1
5430	0	GTF2E1	1	biochemical, pull down, pull down	Scully R (1997), Scully R (1997), Maxon ME (1994)	3
YAF2	1	ATF7IP	5	affinity chromatography technology	Huttlin EL (2017)	1
23429	0	ATF7IP	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VHL	0	5430	0	affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Mikhaylova O (2008), Kuznetsova AV (2003), Kuznetsova AV (2003), Sun W (2017)	4
MAPK3	4	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
GTF2IRD1	6	ATF7IP	5	two hybrid, affinity chromatography technology	Carmona-Mora P (2015), Carmona-Mora P (2015)	2
SUMO2	0	SETDB1	3	two hybrid, two hybrid, pull down	Vinayagam A (2011), Goehler H (2004), Ouyang J (2009)	3
MBD1	1	SUV39H1	0	affinity chromatography technology, pull down, imaging technique	Fujita N (2003), Fujita N (2003), Fujita N (2003)	3
ATF7IP	5	3501	0	affinity chromatography technology	Huttlin EL (2017)	1
ATF7IP	5	GTF2E2	2	affinity chromatography technology	Liu L (2009)	1
ATF7IP	5	MBD1	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Fujita N (2003), Fujita N (2003), Fujita N (2003), Uchimura Y (2006), Ichimura T (2005), Ichimura T (2005)	6
CREB1	1	5430	0	affinity chromatography technology	Li X (2015)	1
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3