PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PNRC2	0	ZBTB48	3	two hybrid	Vinayagam A (2011)	1
ESR1	0	PNRC2	0	two hybrid	Albers M (2005)	1
ESR2	1	PNRC2	0	two hybrid	Albers M (2005)	1
PNRC2	0	DCP1A	1	two hybrid, two hybrid	Albers M (2005), Rolland T (2014)	2
PNRC2	0	SPAG9	5	two hybrid	Vinayagam A (2011)	1
ESR1	0	XRCC6	3	affinity chromatography technology	Ju BG (2006)	1
PNRC2	0	XRCC6	3	two hybrid	Vinayagam A (2011)	1
RORA	4	PNRC2	0	two hybrid	Albers M (2005)	1
HNF4A	2	PNRC2	0	two hybrid	Albers M (2005)	1
ESR2	1	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical	Ogawa S (1998), Ogawa S (1998), Ogawa S (1998), Poelzl G (2000), Rossi V (2009), Monroe DG (2003), Nassa G (2011)	7
HNF4G	1	PNRC2	0	two hybrid	Albers M (2005)	1
FBXO7	1	PNRC2	0	enzymatic study	Teixeira FR (2016)	1
PNRC2	0	GLOD4	3	two hybrid	Vinayagam A (2011)	1
GLOD4	3	APP	1	pull down	Olah J (2011)	1
FBXO7	1	ZBTB48	3	affinity chromatography technology	Hein MY (2015)	1
ESRRG	2	APP	1	pull down	Olah J (2011)	1
APP	1	PNRC2	0	pull down	Virok DP (2011)	1
RARG	2	PNRC2	0	two hybrid	Albers M (2005)	1
NR5A2	4	PNRC2	0	two hybrid	Albers M (2005)	1
ESRRG	2	PNRC2	0	two hybrid, pull down	Albers M (2005), Hentschke M (2003)	2