PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
OTUD5	2	CACYBP	0	affinity chromatography technology	Sowa ME (2009)	1
OTUD5	2	FLNA	10	affinity chromatography technology	Sowa ME (2009)	1
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
OTUD5	2	GPX4	0	affinity chromatography technology	Sowa ME (2009)	1
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
EGLN3	0	CACYBP	0	affinity chromatography technology	Rodriguez J (2016)	1
OTUD5	2	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TP53	0	FLNA	10	affinity chromatography technology	Horikawa I (2014)	1
MOV10	6	OTUD5	2	affinity chromatography technology	Castello A (2012)	1
OTUD5	2	PKLR	0	affinity chromatography technology	Sowa ME (2009)	1
PDCD5	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Xu L (2012), Xu L (2012), Xu L (2012), Xu L (2012), Park SY (2015)	5
OTUD5	2	LANCL2	1	affinity chromatography technology	Sowa ME (2009)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
TRIM35	1	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
SET	8	TP53	0	affinity chromatography technology, pull down	Kim JY (2012), Kim JY (2012)	2
GRB2	2	FLNA	10	affinity chromatography technology	Bisson N (2011)	1
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
GRN	2	OTUD5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	USP11	3	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	OTUD5	2	affinity chromatography technology	Choudhury NR (2017)	1
DUSP13	1	GRB2	2	affinity chromatography technology	Li X (2016)	1
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
MOV10	6	USP11	3	affinity chromatography technology	Castello A (2012)	1
PDCD5	0	OTUD5	2	affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, pull down	Park SY (2015), Park SY (2015), Park SY (2015), Park SY (2015), Park SY (2015)	5
OTUD5	2	CTPS2	0	affinity chromatography technology	Sowa ME (2009)	1
IGBP1	1	OTUD5	2	biochemical	Havugimana PC (2012)	1
OTUD5	2	LONRF2	0	affinity chromatography technology	Sowa ME (2009)	1
TNFAIP3	3	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	LANCL2	1	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
EGLN3	0	OTUD5	2	affinity chromatography technology	Rodriguez J (2016)	1
OTUD5	2	GYS1	1	affinity chromatography technology	Sowa ME (2009)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
OTUD5	2	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down	Sowa ME (2009), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Luo J (2013), Park SY (2015), Park SY (2015), Park SY (2015)	9
OTUD5	2	SET	8	affinity chromatography technology	Sowa ME (2009)	1
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
OTUD5	2	GRB2	2	affinity chromatography technology	Sowa ME (2009)	1
RABGEF1	1	OTUD5	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	GPX4	0	affinity chromatography technology	Choudhury NR (2017)	1
OTUD5	2	VARS	5	affinity chromatography technology	Sowa ME (2009)	1
DUSP13	1	CACYBP	0	affinity chromatography technology	Li X (2016)	1
OTUD5	2	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Kayagaki N (2007), Peng Y (2014)	2
EGLN3	0	IGBP1	1	affinity chromatography technology	Rodriguez J (2016)	1
OTUD5	2	UBC	7	pull down, enzymatic study, enzymatic study, pull down, pull down	Kayagaki N (2007), Huang OW (2012), Mevissen TE (2013), Zhang X (2017), Kwasna D (2018)	5
DUSP13	1	OTUD5	2	affinity chromatography technology	Li X (2016)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1