PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KIF1BP	1	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
FAM19A3	0	GATD1	1	affinity chromatography technology	Huttlin EL (2017)	1
PPARG	0	MED1	4	fluorescent resonance energy transfe, pull down, two hybrid, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, unspecified method, pull down, pull down, two hybrid, unspecified method	Iannone MA (2001), Yang W (2000), Shao G (2000), Treuter E (1999), Albers M (2005), Feige JN (2007), Feige JN (2007), Qin C (2004), Lee G (2002), Agostini M (2006), Carmona MC (2007), Carmona MC (2007), Koppen A (2009)	13
RNF166	0	KIF1A	19	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	KIF1BP	1	affinity chromatography technology	Emdal KB (2015)	1
MDFI	1	SPRY2	4	two hybrid	Rolland T (2014)	1
MED1	4	AR	3	affinity chromatography technology, pull down	Wang Q (2002), Wang Q (2002)	2
SP1	0	AR	3	affinity chromatography technology, affinity chromatography technology	Yuan H (2005), Chen PH (2008)	2
KIF1A	19	SPRY2	4	two hybrid	Corominas R (2014)	1
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
NTRK1	1	MED1	4	affinity chromatography technology	Emdal KB (2015)	1
RNF31	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2014), Zhu J (2014)	2
TRIM27	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
KIF1A	19	KIF5B	1	biochemical	Wan C (2015)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
KIF1A	19	MTUS2	4	two hybrid	Corominas R (2014)	1
PSMC3	0	AR	3	affinity chromatography technology, affinity chromatography technology	Satoh T (2009), Satoh T (2009)	2
HNRNPL	3	KIF1A	19	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	NOTCH2NL	1	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	KIF1A	19	affinity chromatography technology	Emdal KB (2015)	1
COX15	3	KIF1A	19	affinity chromatography technology	Malty RH (2017)	1
PPARG	0	SP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Costa V (2008), Singh AK (2010), Singh AK (2010), Zhang XH (2012), Zhang XH (2012), Zurlo D (2014), Zurlo D (2014)	7
RXRA	1	SP1	0	pull down, affinity chromatography technology	Suzuki Y (1999), Cheng YH (2008)	2
FAM19A3	0	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	KIF5B	1	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	MAPK8IP3	9	affinity chromatography technology	Fei T (2017)	1
KIF1A	19	TRIM27	2	two hybrid	Corominas R (2014)	1
PSMC3	0	KIF1B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIRT7	1	FXR2	2	affinity chromatography technology	Tsai YC (2012)	1
FXR2	2	RBPMS	0	two hybrid	Rual JF (2005)	1
DQX1	2	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
GATD1	1	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	PSMA3	1	affinity chromatography technology	Emdal KB (2015)	1
SIRT7	1	PSMC3	0	affinity chromatography technology	Tsai YC (2012)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
SIRT7	1	KIF5B	1	affinity chromatography technology	Tsai YC (2012)	1
KIF1A	19	TNS2	3	two hybrid	Corominas R (2014)	1
KIF1A	19	TSPOAP1	9	two hybrid	Corominas R (2014)	1
ESR1	0	MED1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Kang YK (2002), Kang YK (2002), Wada-Hiraike O (2005), Burakov D (2000), Burakov D (2000), Burakov D (2000), Burakov D (2000), Llopis J (2000), Llopis J (2000), Fujita T (2003), Fujita T (2003)	11
KIF1A	19	RBPMS	0	two hybrid	Corominas R (2014)	1
NTRK1	1	RNF31	3	affinity chromatography technology	Emdal KB (2015)	1
TNS2	3	SPRY2	4	two hybrid	Grossmann A (2015)	1
PLSCR1	0	EGFR	5	biochemical, affinity chromatography technology	Sun J (2002), Sun J (2002)	2
RGS20	2	AARSD1	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
SP1	0	KIF1A	19	pull down	Miyamoto-Sato E (2010)	1
TRIP6	2	KIF5B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KIF1A	19	FXR2	2	two hybrid	Corominas R (2014)	1
KIF1A	19	RFX6	3	two hybrid	Corominas R (2014)	1
ESR1	0	KIF1A	19	two hybrid	Albers M (2005)	1
EGFR	5	KIF1A	19	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Yao Z (2017)	2
KIF1A	19	MAPK8IP3	9	biochemical	Wan C (2015)	1
LYPD4	1	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	KIF1B	1	affinity chromatography technology	Fei T (2017)	1
KIF1A	19	PSMA3	1	two hybrid	Corominas R (2014)	1
HNRNPL	3	MID2	1	affinity chromatography technology	Fei T (2017)	1
AR	3	KIF1A	19	two hybrid, two hybrid	Albers M (2005), Corominas R (2014)	2
EGFR	5	PSMA3	1	affinity chromatography technology	Yao Z (2017)	1
HNRNPL	3	DOCK5	6	affinity chromatography technology	Fei T (2017)	1
SPRY2	4	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
KIF1A	19	NOTCH2NL	1	two hybrid	Corominas R (2014)	1
KIF1A	19	MKRN3	2	two hybrid	Corominas R (2014)	1
CETN1	0	KIF1B	1	affinity chromatography technology	Huttlin EL (2017)	1
MED1	4	KIF1A	19	two hybrid	Albers M (2005)	1
TRIM35	1	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
TRIP6	2	ADAMTSL4	6	two hybrid	Rolland T (2014)	1
PSMA3	1	PSMC3	0	affinity chromatography technology, biochemical, biochemical, biochemical	Fedorova OA (2011), Bose S (2001), Havugimana PC (2012), Wan C (2015)	4
NTRK1	1	PSMC3	0	affinity chromatography technology	Emdal KB (2015)	1
SPRY2	4	MID2	1	two hybrid	Rolland T (2014)	1
PPARG	0	KIF1A	19	two hybrid	Albers M (2005)	1
KIF1A	19	RGS20	2	two hybrid	Corominas R (2014)	1
KIF1A	19	MDFI	1	two hybrid	Corominas R (2014)	1
DOCK5	6	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
KIF1A	19	TRIP6	2	two hybrid	Corominas R (2014)	1
HNRNPL	3	AR	3	affinity chromatography technology	Fei T (2017)	1
PSMC3	0	KIF1A	19	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
NTRK1	1	MAPK8IP3	9	affinity chromatography technology	Emdal KB (2015)	1
KIF1A	19	TRAF1	0	two hybrid	Corominas R (2014)	1
KIF1A	19	ADAMTSL4	6	two hybrid	Corominas R (2014)	1
HNRNPL	3	RXRA	1	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	FXR2	2	affinity chromatography technology	Emdal KB (2015)	1
CEP152	2	KIF1A	19	bioid	Gupta GD (2015)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
KIF1A	19	PLSCR1	0	two hybrid	Corominas R (2014)	1
PLSCR1	0	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
SIRT7	1	KIF1A	19	affinity chromatography technology	Tsai YC (2012)	1
AARSD1	0	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
RXRA	1	KIF1A	19	two hybrid	Albers M (2005)	1
PPARG	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu Y (2016), Xu Y (2016), Xu Y (2016)	3
MID2	1	ADAMTSL4	6	two hybrid	Rolland T (2014)	1
RXRA	1	MED1	4	imaging technique, pull down, two hybrid, two hybrid	Sinkkonen L (2005), Yang W (2000), Shao G (2000), Osburn DL (2001)	4
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
KIF1BP	1	KIF1B	1	affinity chromatography technology	Huttlin EL (2017)	1
KIF1B	1	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
KIF1A	19	RNF31	3	two hybrid	Corominas R (2014)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
PLSCR1	0	SPRY2	4	two hybrid	Rual JF (2005)	1
CETN1	0	KIF1A	19	affinity chromatography technology	Huttlin EL (2017)	1
KIF1A	19	MID2	1	two hybrid	Corominas R (2014)	1