Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PPARD 5467 SULINDAC CHEMBL15770 negative modulator DrugBank 17409426, 10555149, 14506281, 16418176, 16091736
PPARD 5467 GW501516 CHEMBL38943 agonist TdgClinicalTrial, GuideToPharmacologyInteractions
PPARD 5467 GSK-9578 CHEMBL278590 agonist GuideToPharmacologyInteractions
PPARD 5467 CHEMBL23296 CHEMBL23296 agonist GuideToPharmacologyInteractions
PPARD 5467 ALCOHOL CHEMBL545 NCI 12641735
PPARD 5467 ICOSAPENT ETHYL CHEMBL2095209 TdgClinicalTrial
PPARD 5467 DB959 CHEMBL3545176 agonist TdgClinicalTrial, ChemblInteractions
PPARD 5467 BEZAFIBRATE CHEMBL264374 agonist DrugBank 16168052
PPARD 5467 ELAFIBRANOR CHEMBL3707395 DrugBank
PPARD 5467 INDEGLITAZAR CHEMBL1232583 agonist ChemblInteractions, DrugBank 10592235
PPARD 5467 CHEMBL592652 CHEMBL592652 antagonist GuideToPharmacologyInteractions
PPARD 5467 DOCETAXEL CHEMBL92 PharmGKB
PPARD 5467 THALIDOMIDE CHEMBL468 PharmGKB
PPARD 5467 SODELGLITAZAR CHEMBL2104984 agonist ChemblInteractions
PPARD 5467 AVE0847 CHEMBL3545295 agonist ChemblInteractions
PPARD 5467 ICOSAPENT CHEMBL460026 agonist DrugBank 9610365, 17632107, 10198642, 16507691, 11552681
PPARD 5467 CHEMBL523395 CHEMBL523395 DrugBank 10592235
PPARD 5467 CHEMBL153057 CHEMBL153057 agonist GuideToPharmacologyInteractions, DrugBank 10592235
PPARD 5467 CHEMBL435278 CHEMBL435278 agonist GuideToPharmacologyInteractions
PPARD 5467 L-796449 CHEMBL278994 agonist GuideToPharmacologyInteractions
PPARD 5467 ATORVASTATIN CHEMBL1487 NCI 16139565
PPARD 5467 MBX-8025 CHEMBL3545019 agonist TdgClinicalTrial, ChemblInteractions, TTD
PPARD 5467 TREPROSTINIL CHEMBL1237119 agonist DrugBank 16239641
PPARD 5467 VACCENIC ACID CHEMBL1236642 DrugBank
PPARD 5467 KD3010 CHEMBL3545114 agonist TdgClinicalTrial, ChemblInteractions, DrugBank, TTD
PPARD 5467 CHEMBL202609 CHEMBL202609 DrugBank 10592235
PPARD 5467 GLYCERIN CHEMBL692 agonist DrugBank
PPARD 5467 CHEMBL38508 CHEMBL38508 agonist GuideToPharmacologyInteractions
PPARD 5467 TRETINOIN CHEMBL38 agonist GuideToPharmacologyInteractions
PPARD 5467 CER-002 CHEMBL3544958 agonist TdgClinicalTrial, ChemblInteractions
PPARD 5467 NETOGLITAZONE CHEMBL93747 agonist TTD

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PPARD rs3734254 T docetaxel efficacy yes (allele inferred by frequency comparison with data in pgkb, actual base not listed in paper) Allele T is associated with increased response to docetaxel and thalidomide in people with Prostatic Neoplasms as compared to allele C. 20038957 655388251
PPARD rs6922548 G docetaxel efficacy yes (allele inferred by frequency comparison with dbSNP, actual base not listed in paper) Allele G is associated with increased response to docetaxel and thalidomide in people with Prostatic Neoplasms as compared to allele A. 20038957 655388206
PPARD rs7769719 G docetaxel efficacy yes (allele inferred by frequency comparison with dbSNP, actual base not listed in paper) Allele G is associated with increased response to docetaxel and thalidomide in people with Prostatic Neoplasms as compared to allele A. 20038957 655388209
PPARD rs2016520 C docetaxel efficacy yes (allele inferred by frequency comparison with dbSNP, actual base not listed in paper, dbSNP changed designation of this allele from G/A to C/T at build 132) Allele C is associated with increased response to docetaxel and thalidomide in people with Prostatic Neoplasms as compared to allele T. 20038957 655388236
PPARD rs1883322 C docetaxel efficacy yes (allele inferred by frequency comparison with dbSNP, actual base not listed in paper, dbSNP changed designation of this allele from G/A to C/T at build 132) Allele C is associated with increased response to docetaxel and thalidomide in people with Prostatic Neoplasms as compared to allele T. 20038957 655388213