PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAD23B	1	SOX2	4	affinity chromatography technology, imaging technique	Fong YW (2011), Fong YW (2011)	2
HMGB1	0	RAD23B	1	pull down	Lange SS (2009)	1
POU5F1	0	WWP2	7	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Xu H (2009), Xu H (2009), Xu H (2009), Qian YW (2012), Liao B (2010)	5
POU5F1	0	TUBB4A	3	affinity chromatography technology, affinity chromatography technology	Hawkins PG (2010), Oliviero G (2015)	2
RNF2	1	RPL22	0	affinity chromatography technology	Cao Q (2014)	1
POU5F1	0	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hawkins PG (2010), Oliviero G (2015)	2
FOXD3	1	POU5F1	0	pull down, affinity chromatography technology	Guo Y (2002), Guo Y (2002)	2
POU5F1	0	ZNF143	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen X (2008), Chen X (2008), Chen X (2008)	3
POU5F1	0	NCL	1	affinity chromatography technology, affinity chromatography technology	Hawkins PG (2010), Johansson H (2010)	2
POU5F1	0	HMGB1	0	affinity chromatography technology, affinity chromatography technology	Butteroni C (2000), Hawkins PG (2010)	2
POU5F1	0	ETS2	1	pull down, affinity chromatography technology	Ezashi T (2001), Ezashi T (2001)	2
SALL4	4	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Yang J (2008), Oliviero G (2015)	2
HMGB1	0	XPC	1	pull down, affinity chromatography technology, affinity chromatography technology	Lange SS (2009), Lange SS (2009), Lange SS (2009)	3
CTNNB1	30	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Xu C (2013), Xu C (2013)	2
POU5F1	0	RAD23B	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Fong YW (2011), Fong YW (2011), Fong YW (2011), Oliviero G (2015)	4
NCL	1	RPL22	0	affinity chromatography technology	Salvetti A (2016)	1
XPC	1	RAD23B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Araki M (2001), Bunick CG (2006), Masutani C (1997), Sugasawa K (1998), Sugasawa K (1997), Sugasawa K (1997), Batty D (2000), Li L (1997), Fong YW (2011), Krzeszinski JY (2013), Krzeszinski JY (2013), Bergink S (2012), Bergink S (2012), Huttlin EL (2017), You X (2017)	15
POU5F1	0	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Rosa A (2011), Oliviero G (2015)	2
RNF2	1	NCL	1	affinity chromatography technology	Cao Q (2014)	1
NR0B1	2	POU5F1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Sun C (2009), Sun C (2009), Sun C (2009), Sun C (2009)	4
POU5F1	0	WDR5	2	affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Ang YS (2011), Ang YS (2011), Ang YS (2011), Ang YS (2011)	4
TRIM28	1	SETDB1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Schultz DC (2002), Schultz DC (2002), Ivanov AV (2007)	3
POU5F1	0	RPL22	0	affinity chromatography technology, affinity chromatography technology	Hawkins PG (2010), Oliviero G (2015)	2
SOX2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Xu C (2013), Xu C (2013)	3
ITCH	1	POU5F1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Liao B (2012), Liao B (2012), Liao B (2012), Liao B (2010)	4
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
TRIM28	1	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Seki Y (2010), Seki Y (2010)	2
CTNNB1	30	TUBA1A	13	affinity chromatography technology	Tian Q (2004)	1
SETDB1	3	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Yuan P (2009), Yuan P (2009)	2
WWP2	7	WDR5	2	affinity chromatography technology	Chaudhary N (2014)	1
SOX2	4	TUBA1A	13	affinity chromatography technology	Cox JL (2013)	1
POU5F1	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Fong YW (2011), Oliviero G (2015)	2
RNF2	1	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
RNF2	1	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Endoh M (2008), Endoh M (2008)	2
POU5F1	0	SOX2	4	pull down, affinity chromatography technology, affinity chromatography technology	Remenyi A (2003), Xu C (2013), Oliviero G (2015)	3