PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MRPL4	1	SPATA5L1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATRIP	1	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang Y (2003), Wang Y (2003), Cortez D (2004), Cortez D (2001), Cortez D (2001), Cortez D (2001), Cortez D (2001), Rendtlew Danielsen JM (2009), Kulkarni A (2008), Sivasubramaniam S (2008), Sivasubramaniam S (2008), Itakura E (2004), Itakura E (2004), Itakura E (2004), Pabla N (2008), Pabla N (2011), Collis SJ (2007), Collis SJ (2007), Warmerdam DO (2010), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Bomgarden RD (2004), Choi JH (2007), Lovejoy CA (2009), Huttlin EL (2017)	27
CINP	0	ATRIP	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Lovejoy CA (2009), Lovejoy CA (2009), Lovejoy CA (2009), Rolland T (2014)	4
SPATA5L1	2	C1orf109	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	CINP	0	affinity chromatography technology	Kirli K (2015)	1
CINP	0	APP	1	pull down	Olah J (2011)	1
FBXW7	2	CINP	0	genetic interference	Bailey ML (2015)	1
XPO1	8	GOLGA2	2	affinity chromatography technology	Kirli K (2015)	1
CINP	0	C1orf109	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
SPATA5	7	C1orf109	1	affinity chromatography technology	Blomen VA (2015)	1
CINP	0	SPATA5L1	2	affinity chromatography technology	Huttlin EL (2017)	1
MRPL4	1	CINP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	CINP	0	two hybrid	Rolland T (2014)	1
CINP	0	HECTD1	16	affinity chromatography technology	Huttlin EL (2017)	1
CLUAP1	1	CINP	0	two hybrid	Rual JF (2005)	1
CINP	0	FBF1	2	two hybrid	Rolland T (2014)	1
GOLGA2	2	C1orf109	1	two hybrid	Rolland T (2014)	1
REL	5	C1orf109	1	two hybrid	Rolland T (2014)	1
BAALC	0	CINP	0	two hybrid	Morita K (2015)	1
ATR	6	CINP	0	affinity chromatography technology	Lovejoy CA (2009)	1
BLZF1	0	FBF1	2	two hybrid	Rolland T (2014)	1
SPATA5	7	SPATA5L1	2	affinity chromatography technology, affinity chromatography technology	Blomen VA (2015), Huttlin EL (2017)	2
REL	5	CINP	0	two hybrid	Rolland T (2014)	1
XPO1	8	C1orf109	1	affinity chromatography technology	Kirli K (2015)	1
CLUAP1	1	APP	1	pull down	Olah J (2011)	1
CINP	0	POTEE	3	affinity chromatography technology	Huttlin EL (2017)	1
FBXW7	2	HECTD1	16	affinity chromatography technology	Kourtis N (2015)	1
XPO1	8	BLZF1	0	affinity chromatography technology	Kirli K (2015)	1
GOLGA2	2	FBF1	2	two hybrid	Rolland T (2014)	1
XPO1	8	REL	5	affinity chromatography technology	Kirli K (2015)	1
CINP	0	SYCE1	0	two hybrid	Rolland T (2014)	1
FBF1	2	APP	1	pull down	Olah J (2011)	1
BLZF1	0	CINP	0	two hybrid	Rolland T (2014)	1
SPATA5	7	CINP	0	affinity chromatography technology, affinity chromatography technology	Blomen VA (2015), Huttlin EL (2017)	2
XPO1	8	SPATA5L1	2	affinity chromatography technology	Kirli K (2015)	1
CINP	0	KIF7	3	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPD	3	CINP	0	two hybrid	Lehner B (2004)	1