PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM24	1	TRIM8	6	two hybrid	Woodsmith J (2012)	1
RNF181	0	UBE2N	1	pull down	Pedersen SM (2015)	1
UBE2U	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
FBXO7	1	UBE2D1	0	pull down	Teixeira FR (2016)	1
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
CDA	0	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF181	0	ZMYND10	2	two hybrid	Wang J (2011)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
PSMB9	0	PSMB3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	RNF181	0	two hybrid, pull down, pull down	van Wijk SJ (2009), Brophy TM (2008), Pedersen SM (2015)	3
UBE2E1	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
UBE2E3	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
PEG10	2	RNF181	0	two hybrid	Wang J (2011)	1
RNF181	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
RNF181	0	UBC	7	enzymatic study	Pedersen SM (2015)	1
TRIM24	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
ADIPOR2	3	RNF181	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
FBXO7	1	PSMB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016)	3
PSMB9	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
RNF181	0	VPS11	3	two hybrid	Woodsmith J (2012)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
RNF181	0	BCL10	0	enzymatic study	Pedersen SM (2015)	1
UBE2U	0	RBCK1	0	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
CLK4	1	RNF181	0	two hybrid	Wang J (2011)	1
BIRC2	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
UBE2U	0	VPS11	3	two hybrid	Markson G (2009)	1
SEM1	0	RNF181	0	affinity chromatography technology, affinity chromatography technology	Besche HC (2014), Besche HC (2014)	2
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
FBXO7	1	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RBCK1	0	two hybrid	Markson G (2009)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2D2	0	FBXO7	1	enzymatic study, pull down	Cenciarelli C (1999), Teixeira FR (2016)	2
FBXO7	1	UBE2E1	1	pull down	Teixeira FR (2016)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
RNF181	0	ITGA2B	2	pull down, pull down, affinity chromatography technology	Larkin D (2004), Brophy TM (2008), Brophy TM (2008)	3
FADS1	0	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
SEM1	0	UBC	7	affinity chromatography technology	Besche HC (2014)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
UBE2D2	0	RNF181	0	two hybrid, pull down	van Wijk SJ (2009), Pedersen SM (2015)	2
NPY5R	0	RNF181	0	two hybrid	Wang J (2011)	1
CARD11	4	RNF181	0	fluorescent resonance energy transfe, affinity chromatography technology	Pedersen SM (2015), Pedersen SM (2015)	2
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17
PSMB3	0	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
BTG1	1	RNF181	0	two hybrid	Wang J (2011)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
SEM1	0	FBXO7	1	affinity chromatography technology	Besche HC (2014)	1
RBCK1	0	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
SLC44A5	0	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
RNF181	0	RNF181	0	enzymatic study	Brophy TM (2008)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
FBXO7	1	UBE2D3	1	pull down, pull down	Vingill S (2016), Teixeira FR (2016)	2
SLC32A1	5	RNF181	0	affinity chromatography technology	Huttlin EL (2017)	1
MRPS6	0	RNF181	0	two hybrid	Wang J (2011)	1
BIRC2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Chang YF (2006), Kuiken HJ (2012), Teixeira FR (2016)	3
PSMB9	0	RNF181	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2U	0	TRIM24	1	two hybrid	van Wijk SJ (2009)	1
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
UBE2D4	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3